Title:
USE OF MANNOSE IN INHIBITING PYROPTOSIS OR RELIEVING TOXIC AND SIDE EFFECTS OF CHEMOTHERAPY DRUG
Document Type and Number:
WIPO Patent Application WO/2023/217179
Kind Code:
A1
Abstract:
Provided is use of mannose in inhibiting pyroptosis or relieving toxic and side effects of a chemotherapy drug, which relates to the field of medical science and technologies. Mannose inhibits pyroptosis induced by a chemotherapy drug, such that toxic and side effects caused by the chemotherapy drug on the intestinal tract and the kidney are relieved, and meanwhile, a treatment effect of the chemotherapy drug on a tumor is not affected. Mannose can be used for preparing a drug, a kit, a pharmaceutical composition or a health care product for inhibiting pyroptosis or relieving toxic and side effects of the chemotherapy drug. Side effects caused by the chemotherapy drug on the kidney and the intestinal tract can be relieved. Mannose can be used as a supplementary drug clinically, the toxic and side effects of the chemotherapy drug are relieved as much as possible while the curative effect of the chemotherapy drug is ensured, the physical and psychological health of the patient is improved, and meanwhile, the tumor inhibition effect of the chemotherapy drug is not affected. Therefore, a new choice for clinical medication is provided for a cancer patient.
More Like This:
Inventors:
WU QIAO (CN)
WANG WEIJIA (CN)
AI YUANLI (CN)
CHEN HANGZI (CN)
LIU FANJIAN (CN)
HONG XUEHUI (CN)
FANG WEI (CN)
WANG WEIJIA (CN)
AI YUANLI (CN)
CHEN HANGZI (CN)
LIU FANJIAN (CN)
HONG XUEHUI (CN)
FANG WEI (CN)
Application Number:
PCT/CN2023/093225
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
A61K31/7004; A61P1/00; A61P13/12; A61P39/00
Foreign References:
| CN114903908A | 2022-08-16 | |||
| CN116077512A | 2023-05-09 | |||
| CN109512857A | 2019-03-26 | |||
| CN113121718A | 2021-07-16 |
Other References:
XIE CHEN; LIU YI: "Effect of D-Mannose on Migration, Proliferation and Apoptosis of Gingival Mesenchymal Stem Cells Under Inflammatory Conditions", BEIJING JOURNAL OF STOMATOLOGY, vol. 29, no. 4, 28 August 2021 (2021-08-28), pages 207 - 212, XP009550655, ISSN: 1006-673X
MA JING, WANG QINGPENG, YANG XIANDE, HAO WENPEI, HUANG ZHONGLV, ZHANG JIABAO, WANG XIN, WANG PENG GEORGE: "Glycosylated platinum(IV) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects", DALTON TRANSACTIONS, RSC - ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 45, no. 29, 1 January 2016 (2016-01-01), Cambridge , pages 11830 - 11838, XP093109235, ISSN: 1477-9226, DOI: 10.1039/C6DT02207C
WEI ZEWEI, HUANG LIANFANG, CUI LIAO, ZHU XIAO: "Mannose: Good player and assister in pharmacotherapy", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 129, 1 September 2020 (2020-09-01), FR , pages 110420, XP093109237, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2020.110420
XU XUAN-LI, ZHANG PEI, SHEN YI-HONG, LI HE-QUAN, WANG YUE-HONG, LU GUO-HUA, ZHOU JIAN-YING: "Mannose prevents acute lung injury through mannose receptor pathway and contributes to regulate PPARγ and TGF-β1 level", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, E-CENTURY PUBLISHING CORPORATION, US, vol. 8, no. 6, 1 January 2015 (2015-01-01), US , pages 6214 - 6224, XP093109239, ISSN: 1936-2625
MA JING, WANG QINGPENG, YANG XIANDE, HAO WENPEI, HUANG ZHONGLV, ZHANG JIABAO, WANG XIN, WANG PENG GEORGE: "Glycosylated platinum(IV) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects", DALTON TRANSACTIONS, RSC - ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 45, no. 29, 1 January 2016 (2016-01-01), Cambridge , pages 11830 - 11838, XP093109235, ISSN: 1477-9226, DOI: 10.1039/C6DT02207C
WEI ZEWEI, HUANG LIANFANG, CUI LIAO, ZHU XIAO: "Mannose: Good player and assister in pharmacotherapy", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 129, 1 September 2020 (2020-09-01), FR , pages 110420, XP093109237, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2020.110420
XU XUAN-LI, ZHANG PEI, SHEN YI-HONG, LI HE-QUAN, WANG YUE-HONG, LU GUO-HUA, ZHOU JIAN-YING: "Mannose prevents acute lung injury through mannose receptor pathway and contributes to regulate PPARγ and TGF-β1 level", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, E-CENTURY PUBLISHING CORPORATION, US, vol. 8, no. 6, 1 January 2015 (2015-01-01), US , pages 6214 - 6224, XP093109239, ISSN: 1936-2625
Attorney, Agent or Firm:
GUANGDONG JINTAI ZHIHUI PATENT & TRADEMARK AGENCY (GENERAL PARTNERSHIP) et al. (CN)
Download PDF:
Previous Patent: ROLLING WORKPIECE SURFACE QUALITY PREDICTION METHOD
Next Patent: METHOD FOR TREATING EYE DISEASE OR CONDITION
Next Patent: METHOD FOR TREATING EYE DISEASE OR CONDITION