Title:
USE OF MATE1 GENE IN TREATMENT OF COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2021/004373
Kind Code:
A1
Abstract:
Disclosed are the use of the MATE1 gene and/or protein as a treatment target of colorectal cancer and the use thereof for determining a marker for a treatment plan of colorectal cancer. Also disclosed is the use of the MATE1 protein and/or inhibitor of the encoding gene SLC47A1 thereof in the treatment of colorectal cancer. The down regulation of the expression of MATE1 in the discharge passage of metformin is a key mechanism for the sensitivity of KRAS mutant colorectal cancer cells to metformin; and the transcriptional level of MATE1 is decreased and the concentration of metformin in tumor cells is increased by upregulating the methyltransferase DNMT1 and down-regulating the demethylase TET1/2, thereby enhancing the effect of metformin in inhibiting the proliferation of tumor cells.
Inventors:
GAO GUOQUAN (CN)
ZHOU TI (CN)
YANG XIA (CN)
XIE JINYE (CN)
ZHOU TI (CN)
YANG XIA (CN)
XIE JINYE (CN)
Application Number:
PCT/CN2020/099975
Publication Date:
January 14, 2021
Filing Date:
July 02, 2020
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
C12Q1/6886; A61K31/155; A61K45/06; A61P35/00; G01N33/574
Foreign References:
| CN110144392A | 2019-08-20 | |||
| CN110699440A | 2020-01-17 | |||
| CN110760582A | 2020-02-07 | |||
| CN110760581A | 2020-02-07 | |||
| CN108315398A | 2018-07-24 | |||
| CN104212834A | 2014-12-17 | |||
| KR101468580B1 | 2014-12-03 |
Other References:
DI XIAO, YU GUO, XI LI, JI-YE YIN, WEI ZHENG, XIN-WEN QIU, LING XIAO, RANG-RU LIU,SAI-YING WANG, WEI-JING GONG, HONG-HAO ZHOU, ZHA: "The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients", INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, vol. 2016, 4350712, 10 February 2016 (2016-02-10), pages 1 - 7, XP055772325, ISSN: 1687-8337, DOI: 10.1155/2016/4350712
SUENAGA MITSUKUNI; SCHIRRIPA MARTA; CAO SHU; ZHANG WU; YANG DONGYUN; DADDUZIO VINCENZO; SALVATORE LISA; BORELLI BEATRICE; PIETRANT: "Potential role of polymorphisms in the transporter genesENT1andMATE1/OCT2in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer", EUROPEAN JOURNAL OF CANCER, vol. 86, 6 October 2017 (2017-10-06), pages 197 - 206, XP085280632, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2017.08.033
JINYE XIE, XIA LIANGPING, XIANG WEI, HE WENZHUO, YIN HAOFAN, WANG FANG, GAO TIANXIAO, QI WEIWEI, YANG ZHONGHAN, YANG XIA, ZHOU TI,: "Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 23, 9 June 2020 (2020-06-09), pages 13012 - 13022, XP055772328, ISSN: 0027-8424, DOI: 10.1073/pnas.1918845117
SUENAGA MITSUKUNI; SCHIRRIPA MARTA; CAO SHU; ZHANG WU; YANG DONGYUN; DADDUZIO VINCENZO; SALVATORE LISA; BORELLI BEATRICE; PIETRANT: "Potential role of polymorphisms in the transporter genesENT1andMATE1/OCT2in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer", EUROPEAN JOURNAL OF CANCER, vol. 86, 6 October 2017 (2017-10-06), pages 197 - 206, XP085280632, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2017.08.033
JINYE XIE, XIA LIANGPING, XIANG WEI, HE WENZHUO, YIN HAOFAN, WANG FANG, GAO TIANXIAO, QI WEIWEI, YANG ZHONGHAN, YANG XIA, ZHOU TI,: "Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 23, 9 June 2020 (2020-06-09), pages 13012 - 13022, XP055772328, ISSN: 0027-8424, DOI: 10.1073/pnas.1918845117
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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