Title:
USE OF METHYL GALLATE IN PREPARATION OF DRUGS FOR TREATING OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2023/185448
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines, and in particular, to a use of methyl gallate in the preparation of drugs for treating osteoarthritis. Methyl gallate can relieve the injury of chondrocytes, ameliorate osteoarthritis, and directly protect chondrocytes; the methyl gallate can also inhibit, in a targeted manner, a Pi3k/Akt signaling pathway activated by chondrocytes, thereby reducing the release of inflammatory factors. Besides, the methyl gallate can also play a role in indirectly protecting cartilage by alleviating the inflammatory induction of osteoarthritis and/or chondrocyte viability inhibition and apoptosis caused by wind-cold-damp stimulation, thereby treating and relieving osteoarthritis. In order to better understand the pathological process of osteoarthritis, a new thought and reference are provided for the development of drugs for treating osteoarthritis in the future.
Inventors:
CAO YUELONG (CN)
CHEN YAN (CN)
ZHENG YUXIN (CN)
CHEN BO (CN)
DING DAOFANG (CN)
PANG JIAN (CN)
ZHAN HONGSHENG (CN)
CHEN YAN (CN)
ZHENG YUXIN (CN)
CHEN BO (CN)
DING DAOFANG (CN)
PANG JIAN (CN)
ZHAN HONGSHENG (CN)
Application Number:
PCT/CN2023/081299
Publication Date:
October 05, 2023
Filing Date:
March 14, 2023
Export Citation:
Assignee:
SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE (CN)
International Classes:
A61K31/235; A61P19/02; A61P29/00
Domestic Patent References:
| WO2020050602A1 | 2020-03-12 |
Foreign References:
| CN114931571A | 2022-08-23 | |||
| CN108530314A | 2018-09-14 | |||
| CN104884067A | 2015-09-02 |
Other References:
WENZHOU SCIENCE & TECHNOLOGY BUREAU: "Notice of Wenzhou Science and Technology Bureau on the Establishment of Wenzhou Basic Scientific Research Project (self-funded) in 2021", WENZHOU SCIENCE & TECHNOLOGY BUREAU > GOVERNMENT AFFAIRS DISCLOSURE > TECHNOLOGY PROJECTS - NOTICES, WENZHOU SCIENCE & TECHNOLOGY BUREAU, CN, CN, XP009549989, Retrieved from the Internet
XIAN-BAO ZHANG, WANG YUN: "Mechanism Elucidation of Euphorbia helioscopia for Treatment of Lung Cancer Based on Entity Grammar System", MODERN CHINESE MEDICINE, ZHONG GUO XIAN DAI ZHONG YAO BIAN JI BU, CN, vol. 23, no. 2, 26 March 2021 (2021-03-26), CN , pages 294 - 302, XP093094777, ISSN: 1673-4890, DOI: 10.13313/j.issn.1673-4890.20200324003
XUE SHEN, XUE YAN, CHEN YAN, LI MING, ZHANG HU: "Establishment and Evaluation of Osteoarthritis Model in Vivo and in Vitro Under the Guidance of The Theory of "Wind-Cold-Dampness Causing Arthralgia", JOURNAL OF BASIC CHINESE MEDICINE, vol. 27, no. 11, 4 February 2021 (2021-02-04), pages 1721 - 1724, XP093094778, DOI: 10.19945/j.cnki.issn.1006-3250.2021.11.010
CORREA, LUANA BARBOSA ET AL.: "Protective effect of methyl gallate on murine antigen‑induced arthritis by inhibiting inflammatory process and bone erosion", INFLAMMOPHARMACOLOGY, vol. 30, 2 February 2022 (2022-02-02), pages 251 - 266, XP037714779, DOI: 10.1007/s10787-021-00922-8
CORREA LUANA BARBOSA, PÁDUA TATIANA ALMEIDA, SEITO LEONARDO NOBORU, COSTA THADEU ESTEVAM MOREIRA MARAMALDO, SILVA MAGAIVER ANDRADE: "Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 6, 24 June 2016 (2016-06-24), US , pages 1554 - 1566, XP093094445, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.5b01115
XIAN-BAO ZHANG, WANG YUN: "Mechanism Elucidation of Euphorbia helioscopia for Treatment of Lung Cancer Based on Entity Grammar System", MODERN CHINESE MEDICINE, ZHONG GUO XIAN DAI ZHONG YAO BIAN JI BU, CN, vol. 23, no. 2, 26 March 2021 (2021-03-26), CN , pages 294 - 302, XP093094777, ISSN: 1673-4890, DOI: 10.13313/j.issn.1673-4890.20200324003
XUE SHEN, XUE YAN, CHEN YAN, LI MING, ZHANG HU: "Establishment and Evaluation of Osteoarthritis Model in Vivo and in Vitro Under the Guidance of The Theory of "Wind-Cold-Dampness Causing Arthralgia", JOURNAL OF BASIC CHINESE MEDICINE, vol. 27, no. 11, 4 February 2021 (2021-02-04), pages 1721 - 1724, XP093094778, DOI: 10.19945/j.cnki.issn.1006-3250.2021.11.010
CORREA, LUANA BARBOSA ET AL.: "Protective effect of methyl gallate on murine antigen‑induced arthritis by inhibiting inflammatory process and bone erosion", INFLAMMOPHARMACOLOGY, vol. 30, 2 February 2022 (2022-02-02), pages 251 - 266, XP037714779, DOI: 10.1007/s10787-021-00922-8
CORREA LUANA BARBOSA, PÁDUA TATIANA ALMEIDA, SEITO LEONARDO NOBORU, COSTA THADEU ESTEVAM MOREIRA MARAMALDO, SILVA MAGAIVER ANDRADE: "Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 6, 24 June 2016 (2016-06-24), US , pages 1554 - 1566, XP093094445, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.5b01115
Attorney, Agent or Firm:
SHANGHAI ZHUOYANG INTELLECTUAL PROPERTY AGENT FIRM et al. (CN)
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