Title:
USE OF SERUM/PLASMA MICRORNA IN EARLY DIAGNOSIS OF HBV INFECTION AND LIVER CANCER
Document Type and Number:
WIPO Patent Application WO/2010/043114
Kind Code:
A1
Abstract:
A microRNA combination used for distinguishing HCV-infected persons, HBV-infected persons and HBV-related liver cancer patients from normal persons as well as the use thereof in early diagnosis of HBV infection and HBV-related liver cancer are provided. The combination contains all the serum/plasma microRNAs which have different expression profiles between HCV-infected persons, HBV-infected persons, HBV-related liver cancer patients and normal persons. A kit containing the microRNAs of the combination used for early diagnosis of HBV infection and HBV-positive liver cancer as well as the preparation method thereof are further provided. The main advantages of the kit include high specificity and high sensitivity.
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Inventors:
ZENG KE (CN)
ZHANG CHENYU (CN)
ZHANG JUNFENG (CN)
LI LIMIN (CN)
ZHANG CHENYU (CN)
ZHANG JUNFENG (CN)
LI LIMIN (CN)
Application Number:
PCT/CN2009/001138
Publication Date:
April 22, 2010
Filing Date:
October 13, 2009
Export Citation:
Assignee:
MICROMEDMARK BIOTECH CO LTD (CN)
ZENG KE (CN)
ZHANG CHENYU (CN)
ZHANG JUNFENG (CN)
LI LIMIN (CN)
ZENG KE (CN)
ZHANG CHENYU (CN)
ZHANG JUNFENG (CN)
LI LIMIN (CN)
International Classes:
C12N15/113; C12Q1/68
Domestic Patent References:
| WO2007016548A2 | 2007-02-08 | |||
| WO2008054828A2 | 2008-05-08 |
Foreign References:
| CN101368213A | 2009-02-18 | |||
| CN100999765A | 2007-07-18 |
Other References:
HAN,JUNFENG ET AL.: "Differential microRNAexpression profile of HepG2 cells induced by HBV integration", ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE, vol. 29, no. 22, 30 November 2007 (2007-11-30), pages 2128 - 2130
LIU,YAN ET AL.: "The microRNA gene expression profiling in HepG2 cells transfected with full-long hepatitis B virus genome", MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 32, no. 2, 28 February 2007 (2007-02-28), pages 92 - 95
Y MURAKAMIET ET AL.: "Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non tumorous tissues", ONCOGENE, vol. 25, 31 December 2006 (2006-12-31), pages 2537 - 2545
J MICHAEL THOMSON ET AL.: "A custom microarray platform for analysis of microRNAgene expression", NATURE METHODS, vol. 1, no. 1, 31 October 2004 (2004-10-31), pages 1 - 7
LIU,YAN ET AL.: "The microRNA gene expression profiling in HepG2 cells transfected with full-long hepatitis B virus genome", MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 32, no. 2, 28 February 2007 (2007-02-28), pages 92 - 95
Y MURAKAMIET ET AL.: "Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non tumorous tissues", ONCOGENE, vol. 25, 31 December 2006 (2006-12-31), pages 2537 - 2545
J MICHAEL THOMSON ET AL.: "A custom microarray platform for analysis of microRNAgene expression", NATURE METHODS, vol. 1, no. 1, 31 October 2004 (2004-10-31), pages 1 - 7
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (18th FloorTower 2, Xihuan Plaza, 1 Xizhimenwai Street,Xicheng District, Beijing 4, CN)
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