Title:
USE OF MITOCHONDRIAL FUSION PROTEIN 2 (MFN2) AND VARIANT THEREOF IN IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2024/098193
Kind Code:
A1
Abstract:
Provided is a use of mitochondrial fusion protein 2 (MFN2), an MFN2 variant capable of interacting with SERCA2, or an MFN2 expression promoter in maintaining and/or promoting tumor killing and/or viability of a CD8 T cell. Also provided is a use of a CD8 T cell overexpressing MFN2 or a variant thereof for treatment of cancer.
Inventors:
GAO SONG (CN)
YANG JIEFENG (CN)
LUO LI (CN)
LUO JUNHANG (CN)
LAN PING (CN)
PAN YIHUI (CN)
LIU HUASHAN (CN)
FENG JIANXIONG (CN)
YU BING (CN)
YANG JIEFENG (CN)
LUO LI (CN)
LUO JUNHANG (CN)
LAN PING (CN)
PAN YIHUI (CN)
LIU HUASHAN (CN)
FENG JIANXIONG (CN)
YU BING (CN)
Application Number:
PCT/CN2022/130305
Publication Date:
May 16, 2024
Filing Date:
November 07, 2022
Export Citation:
Assignee:
SUN YAT SEN UNIV CANCER CENTER (CN)
International Classes:
C07K14/435; A61K39/00; A61P35/00; C12N15/00
Domestic Patent References:
| WO2016200778A1 | 2016-12-15 |
Foreign References:
| US20170101624A1 | 2017-04-13 | |||
| US20050181390A1 | 2005-08-18 | |||
| JP2006265117A | 2006-10-05 | |||
| US20180064712A1 | 2018-03-08 |
Other References:
MIRET-CASALS LAIA, SEBASTIÁN DAVID; BREA JOSÉ; RICO-LEO EVA M.; PALACÍN MANUEL; FERNÁNDEZ-SALGUERO PEDRO M.; LOZA M. ISABEL; ALBER: "Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism", CELL CHEMICAL BIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 3, 1 March 2018 (2018-03-01), AMSTERDAM, NL , pages 268 - 278.e4, XP093170792, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2017.12.001
RICCARDO FILADI, DIANA PENDIN, PAOLA PIZZO: "Mitofusin 2: from functions to disease", CELL DEATH & DISEASE, vol. 9, no. 3, 1 March 2018 (2018-03-01), XP055637276, DOI: 10.1038/s41419-017-0023-6
BERĘSEWICZ MAŁGORZATA, CHARZEWSKI ŁUKASZ; KRZYŚKO KRYSTIANA A.; KOCHAŃSKI ANDRZEJ; ZABŁOCKA BARBARA: "Molecular modelling of mitofusin 2 for a prediction for Charcot-Marie-Tooth 2A clinical severity", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, US , XP093170795, ISSN: 2045-2322, DOI: 10.1038/s41598-018-35133-9
RICCARDO FILADI, DIANA PENDIN, PAOLA PIZZO: "Mitofusin 2: from functions to disease", CELL DEATH & DISEASE, vol. 9, no. 3, 1 March 2018 (2018-03-01), XP055637276, DOI: 10.1038/s41419-017-0023-6
BERĘSEWICZ MAŁGORZATA, CHARZEWSKI ŁUKASZ; KRZYŚKO KRYSTIANA A.; KOCHAŃSKI ANDRZEJ; ZABŁOCKA BARBARA: "Molecular modelling of mitofusin 2 for a prediction for Charcot-Marie-Tooth 2A clinical severity", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, US , XP093170795, ISSN: 2045-2322, DOI: 10.1038/s41598-018-35133-9
Attorney, Agent or Firm:
IP MARCH (CN)
Download PDF: