Title:
USE OF MITOXANTRONE HYDROCHLORIDE LIPOSOMES
Document Type and Number:
WIPO Patent Application WO/2021/180184
Kind Code:
A1
Abstract:
A use of mitoxantrone hydrochloride liposomes in the preparation of a drug for the treatment of liver cancer. The liver cancer is preferably advanced liver cancer, and liver cancer on which first-line and/or second-line drug treatment fails or results in intolerance. A method for treating liver cancer, the method comprises: giving a therapeutically effective amount of mitoxantrone hydrochloride liposomes to patients with liver cancer. Animal test results show that mitoxantrone hydrochloride liposomes have better efficacy and lower toxicity. Preliminary clinical research results show that the mitoxantrone hydrochloride liposomes may effectively treat advanced liver cancer and have good safety and tolerability.
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Inventors:
LI CHUNLEI (CN)
ZHANG XI (CN)
LIN HONGMEI (CN)
LI GUIXIA (CN)
LI MENGMENG (CN)
WANG FENGXIA (CN)
WANG SHIXIA (CN)
JIN XIN (CN)
ZHANG XI (CN)
LIN HONGMEI (CN)
LI GUIXIA (CN)
LI MENGMENG (CN)
WANG FENGXIA (CN)
WANG SHIXIA (CN)
JIN XIN (CN)
Application Number:
PCT/CN2021/080282
Publication Date:
September 16, 2021
Filing Date:
March 11, 2021
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)
International Classes:
A61K9/127; A61K31/136; A61P35/00
Foreign References:
| CN101209243A | 2008-07-02 | |||
| CN1602844A | 2005-04-06 | |||
| CN104324001A | 2015-02-04 | |||
| CN1469735A | 2004-01-21 | |||
| CA2424345A1 | 2002-04-25 | |||
| US5858397A | 1999-01-12 |
Other References:
ZHAO QIAN , WANG CAI-XIA , QIU YUN-LIANG , YANG HAN-YU: "Pharmacodynamics and Toxicity of Liposomal Mitoxantrone Hydrochloride", CHINESE PHARMACOLOGICAL BULLETIN, vol. 27, no. 12, 27 December 2011 (2011-12-27), pages 1745 - 1748, XP055846355
HOWARD J. LIM, DANA MASIN, NATASHIA L. MCINTOSH, THOMAS D. MADDEN, MARCEL B. BALLY: "Role of Drug Release and Liposome-Mediated Drug Delivery in Governing the Therapeutic Activity of Liposomal Mitoxantrone Used to Treat Human A431 and LS180 Solid Tumors", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 292, no. 1, 31 December 2000 (2000-12-31), pages 337 - 345, XP009530353, ISSN: 0022-3565
HOWARD J. LIM, DANA MASIN, NATASHIA L. MCINTOSH, THOMAS D. MADDEN, MARCEL B. BALLY: "Role of Drug Release and Liposome-Mediated Drug Delivery in Governing the Therapeutic Activity of Liposomal Mitoxantrone Used to Treat Human A431 and LS180 Solid Tumors", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 292, no. 1, 31 December 2000 (2000-12-31), pages 337 - 345, XP009530353, ISSN: 0022-3565
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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