Title:
USE OF MIXED LINEAGE LIKE KINASE POLYPEPTIDES (MLKL POLYPEPTIDES) IN CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2010/122135
Kind Code:
A3
Abstract:
The present invention pertains to the field of therapeutic and diagnostic compositions. Specifically, it relates to a polynucleotide comprising a nucleic acid sequence encoding a MLKL polypeptide or variants thereof for use as medicament. The present invention relates further to a nucleic acid which specifically binds to a polynucleotide encoding a MLKL polypeptide for use as a medicament, whereby the nucleic acid upon specific binding prevents the generation of a biologically active polypeptide encoded by the said polynucleotide. Additionally, the present invention relates to an antibody or an RNA- aptamer which specifically recognizes a polypeptide encoded by a polynucleotide as specified above for use as a medicament. The present invention also relates to the use of a polynucleotide of the present invention, a nucleic acid of the present invention, or an antibody of the present invention for the manufacture of a medicament for the treatment of cancer. The present invention relates to methods for diagnosing cancer in a subject, methods for assessing whether a subject suffering from cancer will benefit from a MLKL based anti-cancer treatment, methods for identifying MLKL modulators, and a method for the manufacture of medicament comprising the steps of the aforementioned methods and a further step of formulating the modulator as a medicament.
Inventors:
MOLLENHAUER JAN (DK)
HUDLER MELANIE (DE)
BLAICH STEPHANIE (DE)
WITTIG RAINER (DE)
HUDLER MELANIE (DE)
BLAICH STEPHANIE (DE)
WITTIG RAINER (DE)
Application Number:
PCT/EP2010/055418
Publication Date:
January 13, 2011
Filing Date:
April 23, 2010
Export Citation:
Assignee:
DEUTSCHES KREBSFORSCH (DE)
MOLLENHAUER JAN (DK)
HUDLER MELANIE (DE)
BLAICH STEPHANIE (DE)
WITTIG RAINER (DE)
MOLLENHAUER JAN (DK)
HUDLER MELANIE (DE)
BLAICH STEPHANIE (DE)
WITTIG RAINER (DE)
International Classes:
C12N9/12; A61K38/45
Domestic Patent References:
| WO2001060991A2 | 2001-08-23 | |||
| WO2008118258A2 | 2008-10-02 |
Foreign References:
| DE10316701A1 | 2004-11-04 | |||
| US20020172981A1 | 2002-11-21 |
Other References:
LIU T-C ET AL: "Cloning and expression of ZAK, a mixed-lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 274, 11 August 2000 (2000-08-11), pages 811 - 816, XP002167497, ISSN: 0006-291X
DATABASE UniProt [online] 1 October 2002 (2002-10-01), "RecName: Full=Mixed lineage kinase domain-like protein;", XP002601394, retrieved from EBI accession no. UNIPROT:Q8NB16 Database accession no. Q8NB16
DATABASE EMBL [online] 3 May 2002 (2002-05-03), "Homo sapiens mixed lineage kinase domain-like, mRNA (cDNA clone MGC:40065 IMAGE:5214733), complete cds.", XP002601395, retrieved from EBI accession no. EMBL:BC028141 Database accession no. BC028141
DATABASE EMBL [online] 9 September 2005 (2005-09-09), "Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630038I11 product:hypothetical Protein kinase/Tyrosine protein kinase/Serine/threonine protein kinase/Protein kinase domain profile/Protein kinase-like containing protein, full insert sequence.", XP002601396, retrieved from EBI accession no. EMBL:AK170260 Database accession no. AK170260
DATABASE EMBL [online] 9 February 2001 (2001-02-09), "Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130019I15 product:hypothetical Protein kinase/Serine/threonine protein kinase/Tyrosine protein kinase/Protein kinase domain profile/Protein kinase-like containing protein, full insert sequence.", XP002601397, retrieved from EBI accession no. EMBL:AK018636 Database accession no. AK018636
DATABASE EMBL [online] 15 October 2008 (2008-10-15), "Homo sapiens mixed lineage kinase domain-like, mRNA (cDNA clone MGC:40065DE IMAGE:5214733), complete cds.", XP002601398, retrieved from EBI accession no. BC028141
DATABASE UniProt [online] 1 October 2002 (2002-10-01), "RecName: Full=Mixed lineage kinase domain-like protein;", XP002601394, retrieved from EBI accession no. UNIPROT:Q8NB16 Database accession no. Q8NB16
DATABASE EMBL [online] 3 May 2002 (2002-05-03), "Homo sapiens mixed lineage kinase domain-like, mRNA (cDNA clone MGC:40065 IMAGE:5214733), complete cds.", XP002601395, retrieved from EBI accession no. EMBL:BC028141 Database accession no. BC028141
DATABASE EMBL [online] 9 September 2005 (2005-09-09), "Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630038I11 product:hypothetical Protein kinase/Tyrosine protein kinase/Serine/threonine protein kinase/Protein kinase domain profile/Protein kinase-like containing protein, full insert sequence.", XP002601396, retrieved from EBI accession no. EMBL:AK170260 Database accession no. AK170260
DATABASE EMBL [online] 9 February 2001 (2001-02-09), "Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130019I15 product:hypothetical Protein kinase/Serine/threonine protein kinase/Tyrosine protein kinase/Protein kinase domain profile/Protein kinase-like containing protein, full insert sequence.", XP002601397, retrieved from EBI accession no. EMBL:AK018636 Database accession no. AK018636
DATABASE EMBL [online] 15 October 2008 (2008-10-15), "Homo sapiens mixed lineage kinase domain-like, mRNA (cDNA clone MGC:40065DE IMAGE:5214733), complete cds.", XP002601398, retrieved from EBI accession no. BC028141
Attorney, Agent or Firm:
DICK, Alexander (PatentanwälteBad Kreuznacher Str. 27-29, Mannheim, DE)
Download PDF: