Title:
USE OF N-ACETYL-CYSTEINE IN THE TREATMENT OF ALLERGIC PATHOLOGIES OF THE RESPIRATORY TRACT
Document Type and Number:
WIPO Patent Application WO2001007019
Kind Code:
A3
Abstract:
The use of NAC in the manufacture of topical pharmaceutical compositions for the treatment of allergic pathologies of the respiratory tract, more particularly allergic rhinitis and asthma, is described.
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Inventors:
SANTANGELO FRANCESCO (IT)
Application Number:
PCT/EP2000/007036
Publication Date:
September 27, 2001
Filing Date:
July 21, 2000
Export Citation:
Assignee:
ZAMBON SPA (IT)
SANTANGELO FRANCESCO (IT)
SANTANGELO FRANCESCO (IT)
International Classes:
A61K31/198; (IPC1-7): A61K31/198; A61P11/00; A61P11/02; A61P11/06
Domestic Patent References:
| WO1998048839A1 | 1998-11-05 | |||
| WO1998047497A2 | 1998-10-29 | |||
| WO1997046243A1 | 1997-12-11 |
Foreign References:
| EP0504112A2 | 1992-09-16 | |||
| FR2788436A1 | 2000-07-21 |
Other References:
MEIER SYDOW J. ET AL: "[Clinical picture and treatment of exogenously allergic bronchial asthma ]. KLINIK UND THERAPIE DES EXOGEN ALLERGISCHEN ASTHMA BRONCHIALE.", THERAPIEWOCHE, (1975) 25/24 (3368-3379). CODEN: THEWA6, XP000992533
NELEMANS F A: "DRUGS USED IN BRONCHIAL ASTHMA AND COUGH.", DUKES, M. N. G. (ED.). SIDE EFFECTS OF DRUGS ANNUAL, VOL. 6: A WORLDWIDE YEARLY SURVEY OF NEW DATA AND TRENDS. XVIII+478P. EXCERPTA MEDICA: AMSTERDAM, NETHERLANDS;ELSEVIER/NORTH-HOLLAND, INC.: NEW YORK, N.Y., USA (1982) 0 (0), P171-172., XP000992514
KARG F.: "[Courses of treatment of allergic illnesses of the respiratory system of children]. KINDERKUREN BEI ALLERGISCHEN ATEMWEGSERKRANKUNGEN.", ALLERGOLOGIE, (1978) 1/1 (44-49). CODEN: ALLRDI, XP000992555
KROEGEL C (REPRINT) ET AL: "PULMONARY IMMUNE CELLS IN HEALTH AND DISEASE - THE EOSINOPHIL LEUKOCYTE.2.", EUROPEAN RESPIRATORY JOURNAL, (APR 1994) VOL. 7, NO. 4, PP. 743-760. ISSN: 0903-1936., UNIV FREIBURG, DEPT PNEUMOL, MED CLIN, HUGSTETTER STR 55, D-79106 FREIBURG, GERMANY (Reprint);UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON, ENGLAND, XP000992539
VOLKL K.-P. ET AL: "[Treatment of airway diseases with N- acetylcystein. An open therapeutic observational study involving 2,512 patients]. THERAPIE VON ATEMWEGSERKRANKUNGEN MIT N- ACETYLCYSTEIN. EINE OFENE THERAPIEBEOBACHTUNGSSTUDIE AN 2,512 PATIENTEN.", FORTSCHRITTE DER MEDIZIN, (1992) 110/18 (54-60)., XP002165545
YAMASHITA, N. (1) ET AL: "Interleukin (IL)-8 production in eosinophil by the stimulation with granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha and its relationship to NF-kappaB activation.", EUROPEAN RESPIRATORY JOURNAL, (DECEMBER, 1998) VOL. 12, NO. SUPPLEMENT 29 PP. 2S. PRINT. MEETING INFO.: WORLD ASTHMA MEETING BARCELONA, SPAIN DECEMBER 09-13, 1998, XP000997160
DATABASE WPI Week 196800, Derwent World Patents Index; AN 1966-39429f, XP002165546
DE BACKER, W. ET AL: "Sputum ECP levels in COPD patients decrease after treatment with N- acetylcysteine (NAC.", EUROPEAN RESPIRATORY JOURNAL, (SEPT., 1998) VOL. 12, NO. SUPPL. 28, PP. 225S. MEETING INFO.: EUROPEAN RESPIRATORY SOCIETY ANNUAL CONGRESS GENEVA, SWITZERLAND SEPTEMBER 19-23, 1998 THE EUROPEAN RESPIRATORY SOCIETY., XP000997154
NELEMANS F A: "DRUGS USED IN BRONCHIAL ASTHMA AND COUGH.", DUKES, M. N. G. (ED.). SIDE EFFECTS OF DRUGS ANNUAL, VOL. 6: A WORLDWIDE YEARLY SURVEY OF NEW DATA AND TRENDS. XVIII+478P. EXCERPTA MEDICA: AMSTERDAM, NETHERLANDS;ELSEVIER/NORTH-HOLLAND, INC.: NEW YORK, N.Y., USA (1982) 0 (0), P171-172., XP000992514
KARG F.: "[Courses of treatment of allergic illnesses of the respiratory system of children]. KINDERKUREN BEI ALLERGISCHEN ATEMWEGSERKRANKUNGEN.", ALLERGOLOGIE, (1978) 1/1 (44-49). CODEN: ALLRDI, XP000992555
KROEGEL C (REPRINT) ET AL: "PULMONARY IMMUNE CELLS IN HEALTH AND DISEASE - THE EOSINOPHIL LEUKOCYTE.2.", EUROPEAN RESPIRATORY JOURNAL, (APR 1994) VOL. 7, NO. 4, PP. 743-760. ISSN: 0903-1936., UNIV FREIBURG, DEPT PNEUMOL, MED CLIN, HUGSTETTER STR 55, D-79106 FREIBURG, GERMANY (Reprint);UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON, ENGLAND, XP000992539
VOLKL K.-P. ET AL: "[Treatment of airway diseases with N- acetylcystein. An open therapeutic observational study involving 2,512 patients]. THERAPIE VON ATEMWEGSERKRANKUNGEN MIT N- ACETYLCYSTEIN. EINE OFENE THERAPIEBEOBACHTUNGSSTUDIE AN 2,512 PATIENTEN.", FORTSCHRITTE DER MEDIZIN, (1992) 110/18 (54-60)., XP002165545
YAMASHITA, N. (1) ET AL: "Interleukin (IL)-8 production in eosinophil by the stimulation with granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha and its relationship to NF-kappaB activation.", EUROPEAN RESPIRATORY JOURNAL, (DECEMBER, 1998) VOL. 12, NO. SUPPLEMENT 29 PP. 2S. PRINT. MEETING INFO.: WORLD ASTHMA MEETING BARCELONA, SPAIN DECEMBER 09-13, 1998, XP000997160
DATABASE WPI Week 196800, Derwent World Patents Index; AN 1966-39429f, XP002165546
DE BACKER, W. ET AL: "Sputum ECP levels in COPD patients decrease after treatment with N- acetylcysteine (NAC.", EUROPEAN RESPIRATORY JOURNAL, (SEPT., 1998) VOL. 12, NO. SUPPL. 28, PP. 225S. MEETING INFO.: EUROPEAN RESPIRATORY SOCIETY ANNUAL CONGRESS GENEVA, SWITZERLAND SEPTEMBER 19-23, 1998 THE EUROPEAN RESPIRATORY SOCIETY., XP000997154
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