USE OF N-(PYRIDIN-2-YL)PYRIDINE-2-THIOAMIDE OR SALT THEREOF IN PREPARATION OF ANTI-HYPOXIC MEDICAMENT

WIPO Patent Application WO/2023/226614

A1

Disclosed is use of N-(pyridin-2-yl)pyridine-2-thioamide represented by the following formula (I) or a pharmaceutically acceptable salt thereof in the preparation of an anti-hypoxic medicament, for treating or preventing diseases caused by hypoxia. By means of animal experiments and in-vitro cell experiments under hypoxic conditions and taking the currently widely used anti-hypoxic medicament acetazolamide as a control, it is verified that N-(pyridin-2-yl)pyridine-2-thioamide or the pharmaceutically acceptable salt thereof has an anti-hypoxic effect significantly more excellent than that of the existing medicament.

JP6002210	17alpha-hydroxylase /C17, 20-lyase inhibitor
JP6704398	4H-pyrrolo [3,2-c] pyridin-4-one derivative
JP2007513957	Phosphodiesterase 4 Inhibitors Containing N-Substituted Diarylamine Analogs This application claims the benefit of US Provisional Application No. 60 / 528,486 filed December 11, 2003, the entire disclosure of which is incorporated herein by reference. Is what you do.

HE XINHUA (CN)
ZHOU TAO (CN)
CHEN YUAN (CN)
LI AILING (CN)
LI LEI (CN)
LI XIHENG (CN)
ZOU XIAOCUI (CN)
CHEN LIANG (CN)
HE KUN (CN)
ZHANG XUEMIN (CN)

PCT/CN2023/088254

November 30, 2023

April 14, 2023

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ACAD OF MILITARY MEDICAL SCIENCE (CN)

A61K31/444; A61P9/00; A61P11/00; A61P25/00; A61P43/00

US20210069202A1	2021-03-11
JPH06298733A	1994-10-25
US20090163545A1	2009-06-25

YANG, GAOXIA ET AL.: "Targeting Atg4B for Cancer Therapy: Chemical Mediators", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 209, 11 October 2020 (2020-10-11), XP086407130, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112917
SUN SHENGMING, WU YING, FU HONGTUO, GE XIANPING, YOU HONGZHENG, WU XUGAN: "Identification and Characterization of Four Autophagy-Related Genes That Are Expressed in Response to Hypoxia in the Brain of the Oriental River Prawn (Macrobrachium nipponense)", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 20, no. 8, Basel, CH , pages 1856, XP093112416, ISSN: 1422-0067, DOI: 10.3390/ijms20081856
WAN, BAOLAN ET AL.: "Research on Mechanism of Nuclear Respiratory Factor 1 Affecting neuronal autophagy in Neonatal Rat Hypoxic Ischemic Encephalophathy by Regulating ATG4", 2020 NATIONAL ACADEMIC ONLINE CONFERENCE ABSTRACT COLLECTION OF THE CHINESE SOCIETY OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 22 October 2020 (2020-10-22)

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