Title:
USE OF NEURAMINIDASE INHIBITORS TO PREVENT FLU ASSOCIATED BACTERIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO2003026567
Kind Code:
A3
Abstract:
The invention provides a novel use for neuraminidase inhibitors in chemoprophylactic and treatment methods for the prevention, attenuation and treatment of bacterial infections that may occur in association with, or as a sequelae of, viral influenza. The prophylactic methods of the invention are particularly suitable for the prevention of secondary bacterial infections, such as, but not limited to infections of the lower respiratory tract (e.g., pneumonia), middle ear infections (e.g., otitis media) and bacterial sinusitis. The treatment methods are suitable for use in protocols designed to attenuate or treat bacterial infections that occur concurrent with, or as a sequelae of the flu.
Inventors:
MCCULLERS JONATHAN A (US)
Application Number:
PCT/US2002/029417
Publication Date:
August 26, 2004
Filing Date:
September 17, 2002
Export Citation:
Assignee:
ST JUDE CHILDRENS RES HOSPITAL (US)
MCCULLERS JONATHAN A (US)
MCCULLERS JONATHAN A (US)
International Classes:
A61K31/00; A61K31/196; A61K31/215; A61K31/551; A61K31/60; A61K31/7012; A61K31/7056; A61K45/06; (IPC1-7): A61K31/35
Domestic Patent References:
| WO2001038313A1 | 2001-05-31 |
Other References:
DATABASE HCAPLUS [online] MCCULLERS ET AL: "Lethal Synergism between Influenza Virus and Streptococcus Pneunomiae: Characterization of a Mouse Model and the Role of Platelet-Activaiting Factor Receptor", XP002978430, accession no. STN Database accession no. 2002:682662
DATABASE HCAPLUS [online] TREANOR ET AL: "Respiratory Viruses", XP002978431, accession no. STN Database accession no. 2002:500423
DATABASE HCAPLUS [online] HAYDEN, F.G.: "Influenza Virus and Rhinovirus-Related Otitis Media: Potential for Antiviral Intervention", XP002978432, accession no. STN Database accession no. 2001:23517
DATABASE HCAPLUS [online] KAISER ET AL: "Impact of Zanamivir on Antibiotic Use for Respiratory Events Following Acute Influenza in Adolescents and Adults", XP002978433, accession no. STN Database accession no. 2000:880241
DATABASE HCAPLUS [online] HAYDEN ET AL: "Efficacy and Safety of the Neuraminidase Inhibitor Zanamivir in the Treatment of Influenzavirus Infections", XP002978434, accession no. STN Database accession no. 1997:638681
DATABASE MEDLINE [online] COLACINO ET AL: "Approaches and strategies for the treatment of influenza virus infections", XP002978405, accession no. STN Database accession no. 1999408613
DATABASE MEDLINE [online] DANIEL ET AL: "The low potential for drug interactions with zanamivir", XP002978406, accession no. STN Database accession no. 1999358487
DATABASE HCAPLUS [online] TREANOR ET AL: "Respiratory Viruses", XP002978431, accession no. STN Database accession no. 2002:500423
DATABASE HCAPLUS [online] HAYDEN, F.G.: "Influenza Virus and Rhinovirus-Related Otitis Media: Potential for Antiviral Intervention", XP002978432, accession no. STN Database accession no. 2001:23517
DATABASE HCAPLUS [online] KAISER ET AL: "Impact of Zanamivir on Antibiotic Use for Respiratory Events Following Acute Influenza in Adolescents and Adults", XP002978433, accession no. STN Database accession no. 2000:880241
DATABASE HCAPLUS [online] HAYDEN ET AL: "Efficacy and Safety of the Neuraminidase Inhibitor Zanamivir in the Treatment of Influenzavirus Infections", XP002978434, accession no. STN Database accession no. 1997:638681
DATABASE MEDLINE [online] COLACINO ET AL: "Approaches and strategies for the treatment of influenza virus infections", XP002978405, accession no. STN Database accession no. 1999408613
DATABASE MEDLINE [online] DANIEL ET AL: "The low potential for drug interactions with zanamivir", XP002978406, accession no. STN Database accession no. 1999358487
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