Title:
USE OF NOVEL COMPOUND, FOR PREVENTING, IMPROVING OR TREATING AMYOTROPHIC LATERAL SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2021/086101
Kind Code:
A1
Abstract:
The present invention relates to a use of a novel compound, for preventing, improving or treating amyotrophic lateral sclerosis (ALS). The present inventors have found that SOD1 aggregation is one of the important causes of ALS, and have proposed the possibility that WT-SOD1 aggregation, caused by suppressing the regulation of intracellular stress or TDP-43, may be a cause of sALS. In addition, the present inventors have discovered the novel compound PRG-A-01 (SLC-B036) as a SOD1 aggregation and misfolding inhibitor. The compound exhibited a protective effect against muscle weakness and movement disorder in an ALS mouse model. According to the result of a histological analysis, intraspinal nerves were maintained by means of a treatment using PRG-A-01 (SLC-B036). In addition, the present inventors have obtained a candidate compound (PRG-A-04) which can be a more optimized drug. Consequently, the compound of the present invention may be usefully employed in developing a therapeutic agent for ALS.
Inventors:
PARK BUM-JOON (KR)
Application Number:
PCT/KR2020/015014
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
Assignee:
PRG S&TECH INC (KR)
International Classes:
C07D493/04; A23L33/10; A61K31/37; A61P21/00
Domestic Patent References:
| WO2003087082A1 | 2003-10-23 | |||
| WO2012128521A2 | 2012-09-27 |
Other References:
LEE JEE-HYUN; KIM MIN-AH; PARK SEOYOUNG; CHO SOO-HYUN; YUN EUNJU; O YU-SEOK; KIM JISEON; GOO JA-IL; YUN MI-YOUNG; CHOI YONGSEOK; O: "Synthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/β-catenin pathway", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 26, no. 15, 11 June 2016 (2016-06-11), Amsterdam , NL, pages 3529 - 3532, XP029642132, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.06.029
LI, L.;LI, W.;JUNG, S.W.;LEE, W.W.;KIM, Y.H.;: "Protective effects of decursin and decursinol angelate against amyloid beta-protein-induced oxidative stress in the PC12 cell line: The role of Nrf2 and antioxidant enzymes", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY, JP, 1 February 2012 (2012-02-01), JP, pages 434 - 442, XP018502860, ISSN: 0916-8451
ZHANG JINHUI, LI LI, JIANG CHENG, XING CHENGGUO, KIM SUNG-HOON, LÜ JUNXUAN: "Anti-cancer and Other Bioactivities of Korean Angelica gigas Nakai (AGN) and Its Major Pyranocoumarin Compounds", CANCER AGENTS IN MEDICINAL CHEMISTRY, vol. 12, 1 January 2012 (2012-01-01), pages 1239 - 1254, XP055807448
RAKHIT, R. ; CHAKRABARTTY, A.: "Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., AMSTERDAM, NL, vol. 1762, no. 11-12, 1 November 2006 (2006-11-01), NL, pages 1025 - 1037, XP027998114, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2006.05.004
CAS, no. 67526-95-8
See also references of EP 4056573A4
LI, L.;LI, W.;JUNG, S.W.;LEE, W.W.;KIM, Y.H.;: "Protective effects of decursin and decursinol angelate against amyloid beta-protein-induced oxidative stress in the PC12 cell line: The role of Nrf2 and antioxidant enzymes", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY, JP, 1 February 2012 (2012-02-01), JP, pages 434 - 442, XP018502860, ISSN: 0916-8451
ZHANG JINHUI, LI LI, JIANG CHENG, XING CHENGGUO, KIM SUNG-HOON, LÜ JUNXUAN: "Anti-cancer and Other Bioactivities of Korean Angelica gigas Nakai (AGN) and Its Major Pyranocoumarin Compounds", CANCER AGENTS IN MEDICINAL CHEMISTRY, vol. 12, 1 January 2012 (2012-01-01), pages 1239 - 1254, XP055807448
RAKHIT, R. ; CHAKRABARTTY, A.: "Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., AMSTERDAM, NL, vol. 1762, no. 11-12, 1 November 2006 (2006-11-01), NL, pages 1025 - 1037, XP027998114, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2006.05.004
CAS, no. 67526-95-8
See also references of EP 4056573A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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