Title:
USE OF OBATOCLAX IN TREATING METABOLIC AND FIBROTIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/096448
Kind Code:
A1
Abstract:
The present invention relates to a use of Obatoclax in treating metabolic and fibrotic diseases, and more specifically, to a novel use of Obatoclax in preventing or treating metabolic and fibrotic diseases, wherein Obatoclax exhibits the effects of inhibiting lipid accumulation and improving fibrosis-related indicators.
Inventors:
LEE SOO MIN (KR)
KIM JONG IN (KR)
KIM JEONG HOON (KR)
KIM JONG IN (KR)
KIM JEONG HOON (KR)
Application Number:
PCT/KR2022/018991
Publication Date:
June 01, 2023
Filing Date:
November 28, 2022
Export Citation:
Assignee:
SK CHEMICALS CO LTD (KR)
International Classes:
A61K31/404; A61K31/42; A61K31/505; A61K45/06; A61P3/00; A61P43/00
Domestic Patent References:
| WO2014174511A1 | 2014-10-30 |
Foreign References:
| KR20160117519A | 2016-10-10 |
Other References:
DAI WENLI, CHENG JIN, LENG XI, HU XIAOQING, AO YINGFANG: "The potential role of necroptosis in clinical diseases (Review)", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 47, no. 5, GR , XP093068760, ISSN: 1107-3756, DOI: 10.3892/ijmm.2021.4922
BENEDICTO ANA M., FUSTER-MARTÍNEZ ISABEL, TOSCA JOAN, ESPLUGUES JUAN V., BLAS-GARCÍA ANA, APOSTOLOVA NADEZDA: "NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved", CELLS, vol. 10, no. 7, 4 July 2021 (2021-07-04), pages 1687, XP093068762, DOI: 10.3390/cells10071687
GEISLER CAROLINE E., GHIMIRE SUSMA, BRUGGINK STEPHANIE M., MILLER KENDRA E., WENINGER SAVANNA N., KRONENFELD JASON M., YOSHINO JUN: "A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity", CELL REPORTS, ELSEVIER INC, US, vol. 35, no. 13, 1 June 2021 (2021-06-01), US , pages 109301, XP093068764, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2021.109301
BENEDICTO ANA M., FUSTER-MARTÍNEZ ISABEL, TOSCA JOAN, ESPLUGUES JUAN V., BLAS-GARCÍA ANA, APOSTOLOVA NADEZDA: "NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved", CELLS, vol. 10, no. 7, 4 July 2021 (2021-07-04), pages 1687, XP093068762, DOI: 10.3390/cells10071687
GEISLER CAROLINE E., GHIMIRE SUSMA, BRUGGINK STEPHANIE M., MILLER KENDRA E., WENINGER SAVANNA N., KRONENFELD JASON M., YOSHINO JUN: "A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity", CELL REPORTS, ELSEVIER INC, US, vol. 35, no. 13, 1 June 2021 (2021-06-01), US , pages 109301, XP093068764, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2021.109301
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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