Title:
USE OF A PENTOPYRANOSYL NUCLEOSIDE FOR PRODUCING AN ELECTRONIC COMPONENT, AND CONJUGATES OF SAID PENTOPYRANOSYL NUCLEOSIDE
Document Type and Number:
WIPO Patent Application WO1999015541
Kind Code:
A3
Abstract:
The invention relates to a pentopyranosyl nucleoside of formula (I) or formula (II), the production of said pentopyranosyl nucleoside, and to its use for producing a therapeutic agent, a diagnostic agent, and/or an electronic component.
Inventors:
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
Application Number:
PCT/EP1998/005999
Publication Date:
June 17, 1999
Filing Date:
September 21, 1998
Export Citation:
Assignee:
AVENTIS RES & TECH GMBH & CO (DE)
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
International Classes:
A61K49/00; C07H1/00; C12Q1/68; C07H19/04; C07H19/067; C07H21/00; C07K16/00; G01N33/532; (IPC1-7): C07H21/00; C12Q1/68
Domestic Patent References:
| WO1996040711A1 | 1996-12-19 | |||
| WO1998025943A1 | 1998-06-18 |
Other References:
S.PITSCH ET AL.: "147. Why Pentose- and Not Hexose-Nucleic Acids ? Pyranosyl-RNA ('p-RNA').", HELVETICA CHIMICA ACTA., vol. 76, no. 6, 1993, BASEL CH, pages 2161 - 2183, XP002094190
S.PITSCH ET AL.: "122. Pyranosyl-RNA ('p-RNA'): Base-Pairing Selectivity and Potential to Replicate.", HELVETICA CHIMICA ACTA., vol. 78, no. 7, 1995, BASEL CH, pages 1621-1635, XP002096830
I.SCHLÖNVOGT ET AL.: "188. Pyranosyl-RNA('p-RNA'): NMR and Molecular Dynamics Study of the Duplex Formed by Self-Pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G).", HELVETICA CHIMICA ACTA., vol. 79, no. 8, 11 December 1996 (1996-12-11), BASEL CH, pages 2316 - 2345, XP002096829
B.DOBOSZEWSKI ET AL.: "Synthesis of 3'-Deoxy-3'-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation into Oligonucleotides. Part II.", TETRAHEDRON, vol. 51, no. 45, 1995, pages 12319 - 12336, XP004104700
CHEMICAL ABSTRACTS, vol. 114, no. 19, 13 May 1991, Columbus, Ohio, US; abstract no. 185912, M.TAKTAKISHVILI ET AL.: "Synthesis of 1-beta-D-ribofuranosyl- and -ribofuranosyl-6-nitroindole and Indoline for Phosphotriester Oligonucleotide Synthesis." XP002096833
Y.HAYAKAWA ET AL.: "O-Allyl Protection of Guanine and Thymine Residues in Oligodeoxyribonucleotides.", JOURNAL OF ORGANIC CHEMISTRY., vol. 58, 1993, EASTON US, pages 5551 - 5555, XP002094188
M.BOLLI ET AL.: "131. Pyranosyl-RNA : Further Observations on Replication.", HELVETICA CHIMICA ACTA., vol. 80, no. 6, 22 September 1997 (1997-09-22), BASEL CH, pages 1901 - 1951, XP002096832
S.PITSCH ET AL.: "122. Pyranosyl-RNA ('p-RNA'): Base-Pairing Selectivity and Potential to Replicate.", HELVETICA CHIMICA ACTA., vol. 78, no. 7, 1995, BASEL CH, pages 1621-1635, XP002096830
I.SCHLÖNVOGT ET AL.: "188. Pyranosyl-RNA('p-RNA'): NMR and Molecular Dynamics Study of the Duplex Formed by Self-Pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G).", HELVETICA CHIMICA ACTA., vol. 79, no. 8, 11 December 1996 (1996-12-11), BASEL CH, pages 2316 - 2345, XP002096829
B.DOBOSZEWSKI ET AL.: "Synthesis of 3'-Deoxy-3'-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation into Oligonucleotides. Part II.", TETRAHEDRON, vol. 51, no. 45, 1995, pages 12319 - 12336, XP004104700
CHEMICAL ABSTRACTS, vol. 114, no. 19, 13 May 1991, Columbus, Ohio, US; abstract no. 185912, M.TAKTAKISHVILI ET AL.: "Synthesis of 1-beta-D-ribofuranosyl- and -ribofuranosyl-6-nitroindole and Indoline for Phosphotriester Oligonucleotide Synthesis." XP002096833
Y.HAYAKAWA ET AL.: "O-Allyl Protection of Guanine and Thymine Residues in Oligodeoxyribonucleotides.", JOURNAL OF ORGANIC CHEMISTRY., vol. 58, 1993, EASTON US, pages 5551 - 5555, XP002094188
M.BOLLI ET AL.: "131. Pyranosyl-RNA : Further Observations on Replication.", HELVETICA CHIMICA ACTA., vol. 80, no. 6, 22 September 1997 (1997-09-22), BASEL CH, pages 1901 - 1951, XP002096832
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