Title:
USE OF PERICYTE APOPTOSIS INHIBITORS FOR TREATING AND/OR PREVENTING DIABETIC RETINOPATHY
Document Type and Number:
WIPO Patent Application WO2002034201
Kind Code:
A3
Abstract:
The invention concerns the use of a retinal pericyte apoptosis inhibitor for preparing a medicine useful for preventing or treating diabetic retinopathy. More particularly, the invention concerns the use of a compound selected among: an antioxidant, a compound inhibiting the production of ceramides and/or of DAG, an acid sphingomyelinase inhibitor, a C phosphatidylcholin-phospholipase inhibitor, a caspase inhibitor, or a mixture of at least two thereof for preparing a medicine useful for preventing or treating diabetic retinopathy.
Inventors:
LECOMTE MARC (FR)
DENIS ULRICHE (FR)
PAGET CLARISSE (FR)
WIERNSPERGER NICOLAS (FR)
LAGARDE MICHEL (FR)
DENIS ULRICHE (FR)
PAGET CLARISSE (FR)
WIERNSPERGER NICOLAS (FR)
LAGARDE MICHEL (FR)
Application Number:
PCT/FR2001/003306
Publication Date:
March 27, 2003
Filing Date:
October 24, 2001
Export Citation:
Assignee:
LIPHA (FR)
INST NAT SANTE RECH MED (FR)
LECOMTE MARC (FR)
DENIS ULRICHE (FR)
PAGET CLARISSE (FR)
WIERNSPERGER NICOLAS (FR)
LAGARDE MICHEL (FR)
INST NAT SANTE RECH MED (FR)
LECOMTE MARC (FR)
DENIS ULRICHE (FR)
PAGET CLARISSE (FR)
WIERNSPERGER NICOLAS (FR)
LAGARDE MICHEL (FR)
International Classes:
C12N15/09; A61K31/00; A61K31/047; A61K31/13; A61K31/19; A61K31/198; A61K31/385; A61K31/55; A61K31/555; A61K31/7088; A61K38/00; A61K38/08; A61K38/43; A61K38/55; A61K45/00; A61K45/06; A61K48/00; A61P3/10; A61P27/02; C12Q1/02; (IPC1-7): A61K31/195; A61K31/385; A61K31/41; A61K31/045; A61K31/495; A61K31/645; A61K31/185; A61K31/00; A61K38/55; A61K38/57; A61K38/06; A61K31/07; A61K38/08; A61K45/06; A61K48/00
Domestic Patent References:
| WO1999002174A1 | 1999-01-21 | |||
| WO1995017900A1 | 1995-07-06 | |||
| WO1998033494A1 | 1998-08-06 | |||
| WO1998047534A1 | 1998-10-29 | |||
| WO2000018392A1 | 2000-04-06 | |||
| WO2000074672A1 | 2000-12-14 | |||
| WO2000047218A1 | 2000-08-17 |
Foreign References:
| US5527533A | 1996-06-18 | |||
| US6103756A | 2000-08-15 | |||
| US6288106B1 | 2001-09-11 |
Other References:
HAMMES H P ET AL: "NERVE GROWTH FACTOR PREVENTS BOTH NEURORETINAL PROGRAMMED CELL DEATH AND CAPILLARY PATHOLOGY IN EXPERIMENTAL DIABETES", MOLECULAR MEDICINE, BLACKWELL SCIENCE, CAMBRIDGE, MA, US, vol. 1, no. 5, July 1995 (1995-07-01), pages 527 - 534, XP000908866, ISSN: 1076-1551
ANSARI N H ET AL: "PREVENTION OF PERICYTE LOSS BY TROLOX IN DIABETIC RAT RETINA", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, XX, XX, vol. 54, no. 6, 24 July 1998 (1998-07-24), pages 467 - 475, XP001011588, ISSN: 0098-4108
DATABASE WPI Week 199637, Derwent World Patents Index; AN 1996-368106, XP002173136, YAMAUCHI KENJI; MATSUNO SUMIO ET AL.: "Antioxidizing agents"
DATABASE WPI Week 199730, Derwent World Patents Index; AN 1997-331169, XP002173137, AVETISOV ES ET AL.: "Composition for antioxidant protection of eye media and tissues - contains immobilised emoxipin and pyridoxine hydrochloride"
KOWLURU R A ET AL: "ABNORMALITIES OF RETINAL METABOLISM IN DIABETES OR EXPERIMENTAL GALACTOSEMIA. VI. COMPARISON OF RETINAL AND CEREBRAL CORTEX METABOLISM, AND EFFECTS OF ANTIOXIDANT THERAPY", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, XX, vol. 26, no. 3/4, February 1999 (1999-02-01), pages 371 - 378, XP001011532, ISSN: 0891-5849
CHENG FENG YANG ET AL: "INTRACELLULAR THIOL DEPLETION CAUSES MITOCHONDRIAL PERMEABILITY TRANSITION IN EBSELEN-INDUCED APOPTOSIS", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, vol. 380, no. 2, 15 August 2000 (2000-08-15), pages 319 - 330, XP002940577, ISSN: 0003-9861
STEFANELLI C ET AL: "NITRIC OXIDE CAN FUNCTION AS EITHER A KILLER MOLECULE OR AN ANTIAPOPTOTIC EFFECTOR IN CARDIOMYOCYTES", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1450, 1999, pages 406 - 413, XP001011533, ISSN: 0167-4889
OBROSOVA I G ET AL: "EARLY CHANGES IN LIPID PEROXIDATION AND ANTIOXIDATIVE DEFENSE IN DIABETIC RAT RETINA: EFFECT OF DL-ALPHA-LIPOIC ACID", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 398, no. 1, 9 June 2000 (2000-06-09), pages 139 - 146, XP001011534, ISSN: 0014-2999
PARFITT K: "Martindale - The complete drug reference - Thirty-second Edition", MARTINDALE: THE COMPLETE DRUG REFERENCE. (FORMERLY MARTINDALE THE EXTRA PHARMACOPEIA), LONDON: PHARMACEUTICAL PRESSS, GB, 1999, pages 1052 - 1054,1574,1636, XP002173135, ISBN: 0-85369-429-X
GIARDINO I ET AL: "AMINOGUANIDINE INHIBITS REACTIVE OXYGEN SPECIES FORMATION, LIPID PEROXIDATION, AND OXIDANT-INDUCED APOPTOSIS", DIABETES, NEW YORK, NY, US, vol. 47, no. 7, July 1998 (1998-07-01), pages 1114 - 1120, XP001064401, ISSN: 0012-1797
NARUSE K ET AL: "Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD., LONDON, GB, vol. 71, no. 3, September 2000 (2000-09-01), pages 309 - 315, XP002194076, ISSN: 0014-4835
SCHEWE T: "MOLECULAR ACTIONS OF EBSELEN-AN ANTIINFLAMMATORY ANTIOXIDANT", GENERAL PHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 26, no. 6, October 1995 (1995-10-01), pages 1153 - 1169, XP002940585, ISSN: 0306-3623
CHUN H S ET AL: "DOPAMINERGIC CELL DEATH INDUCED BY MPP+, OXIDANT AND SPECIFIC NEUROTOXICANTS SHARES THE COMMON MOLECULAR MECHANISM", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 4, February 2001 (2001-02-01), pages 1010 - 1021, XP002940581, ISSN: 0022-3042
KOWLURU R ET AL.: "Abnormalities of retinal metabolism in diabetes and experimental galactosemia", DIABETES, vol. 50, no. 8, August 2001 (2001-08-01), pages 1938 - 1942, XP001064406
DENIS U ET AL: "ADVANCED GLYCATION END-PRODUCTS (AGE) INDUCE APOPTOSIS OF CULTURED BOVINE RETINAL PERICYTES: IMPLICATION OF CASPASES AND DAG/CERAMIDE PRODUCTION", DIABETES, NEW YORK, NY, US, vol. 50, no. SUPPL 2, June 2001 (2001-06-01), pages A192, XP001064430, ISSN: 0012-1797
RUDEL T: "CASPASE INHIBITORS IN PREVENTION OF APOPTOSIS CASPASEINHIBITOREN ZUR PRAEVENTION VON APOPTOSE", HERZ, URBAN UND VOGEL, MUENCHEN, DE, vol. 24, no. 3, 1994, pages 236 - 241, XP001009833, ISSN: 0340-9937
WEI Y ET AL: "THE STRUCTURES OF CASPASES-1, -3, -7 AND -8 REVEAL THE BASIS FOR SUBSTRATE AND INHIBITOR SELECTIVITY", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 6, 2000, pages 423 - 432, XP001024055, ISSN: 1074-5521
SCHOTTE P ET AL: "Non-specific effects of methyl ketone peptide inhibitors of caspases", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 442, no. 1, 8 January 1999 (1999-01-08), pages 117 - 121, XP004259015, ISSN: 0014-5793
GARCIA-CALVO MARGARITA ET AL: "Inhibition of human caspases by peptide-based and macromolecular inhibitors.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, 4 December 1998 (1998-12-04), pages 32608 - 32613, XP002222060, ISSN: 0021-9258
ANSARI N H ET AL: "PREVENTION OF PERICYTE LOSS BY TROLOX IN DIABETIC RAT RETINA", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, XX, XX, vol. 54, no. 6, 24 July 1998 (1998-07-24), pages 467 - 475, XP001011588, ISSN: 0098-4108
DATABASE WPI Week 199637, Derwent World Patents Index; AN 1996-368106, XP002173136, YAMAUCHI KENJI; MATSUNO SUMIO ET AL.: "Antioxidizing agents"
DATABASE WPI Week 199730, Derwent World Patents Index; AN 1997-331169, XP002173137, AVETISOV ES ET AL.: "Composition for antioxidant protection of eye media and tissues - contains immobilised emoxipin and pyridoxine hydrochloride"
KOWLURU R A ET AL: "ABNORMALITIES OF RETINAL METABOLISM IN DIABETES OR EXPERIMENTAL GALACTOSEMIA. VI. COMPARISON OF RETINAL AND CEREBRAL CORTEX METABOLISM, AND EFFECTS OF ANTIOXIDANT THERAPY", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, XX, vol. 26, no. 3/4, February 1999 (1999-02-01), pages 371 - 378, XP001011532, ISSN: 0891-5849
CHENG FENG YANG ET AL: "INTRACELLULAR THIOL DEPLETION CAUSES MITOCHONDRIAL PERMEABILITY TRANSITION IN EBSELEN-INDUCED APOPTOSIS", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, vol. 380, no. 2, 15 August 2000 (2000-08-15), pages 319 - 330, XP002940577, ISSN: 0003-9861
STEFANELLI C ET AL: "NITRIC OXIDE CAN FUNCTION AS EITHER A KILLER MOLECULE OR AN ANTIAPOPTOTIC EFFECTOR IN CARDIOMYOCYTES", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1450, 1999, pages 406 - 413, XP001011533, ISSN: 0167-4889
OBROSOVA I G ET AL: "EARLY CHANGES IN LIPID PEROXIDATION AND ANTIOXIDATIVE DEFENSE IN DIABETIC RAT RETINA: EFFECT OF DL-ALPHA-LIPOIC ACID", EUROPEAN JOURNAL OF PHARMACOLOGY, AMSTERDAM, NL, vol. 398, no. 1, 9 June 2000 (2000-06-09), pages 139 - 146, XP001011534, ISSN: 0014-2999
PARFITT K: "Martindale - The complete drug reference - Thirty-second Edition", MARTINDALE: THE COMPLETE DRUG REFERENCE. (FORMERLY MARTINDALE THE EXTRA PHARMACOPEIA), LONDON: PHARMACEUTICAL PRESSS, GB, 1999, pages 1052 - 1054,1574,1636, XP002173135, ISBN: 0-85369-429-X
GIARDINO I ET AL: "AMINOGUANIDINE INHIBITS REACTIVE OXYGEN SPECIES FORMATION, LIPID PEROXIDATION, AND OXIDANT-INDUCED APOPTOSIS", DIABETES, NEW YORK, NY, US, vol. 47, no. 7, July 1998 (1998-07-01), pages 1114 - 1120, XP001064401, ISSN: 0012-1797
NARUSE K ET AL: "Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD., LONDON, GB, vol. 71, no. 3, September 2000 (2000-09-01), pages 309 - 315, XP002194076, ISSN: 0014-4835
SCHEWE T: "MOLECULAR ACTIONS OF EBSELEN-AN ANTIINFLAMMATORY ANTIOXIDANT", GENERAL PHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 26, no. 6, October 1995 (1995-10-01), pages 1153 - 1169, XP002940585, ISSN: 0306-3623
CHUN H S ET AL: "DOPAMINERGIC CELL DEATH INDUCED BY MPP+, OXIDANT AND SPECIFIC NEUROTOXICANTS SHARES THE COMMON MOLECULAR MECHANISM", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 4, February 2001 (2001-02-01), pages 1010 - 1021, XP002940581, ISSN: 0022-3042
KOWLURU R ET AL.: "Abnormalities of retinal metabolism in diabetes and experimental galactosemia", DIABETES, vol. 50, no. 8, August 2001 (2001-08-01), pages 1938 - 1942, XP001064406
DENIS U ET AL: "ADVANCED GLYCATION END-PRODUCTS (AGE) INDUCE APOPTOSIS OF CULTURED BOVINE RETINAL PERICYTES: IMPLICATION OF CASPASES AND DAG/CERAMIDE PRODUCTION", DIABETES, NEW YORK, NY, US, vol. 50, no. SUPPL 2, June 2001 (2001-06-01), pages A192, XP001064430, ISSN: 0012-1797
RUDEL T: "CASPASE INHIBITORS IN PREVENTION OF APOPTOSIS CASPASEINHIBITOREN ZUR PRAEVENTION VON APOPTOSE", HERZ, URBAN UND VOGEL, MUENCHEN, DE, vol. 24, no. 3, 1994, pages 236 - 241, XP001009833, ISSN: 0340-9937
WEI Y ET AL: "THE STRUCTURES OF CASPASES-1, -3, -7 AND -8 REVEAL THE BASIS FOR SUBSTRATE AND INHIBITOR SELECTIVITY", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 6, 2000, pages 423 - 432, XP001024055, ISSN: 1074-5521
SCHOTTE P ET AL: "Non-specific effects of methyl ketone peptide inhibitors of caspases", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 442, no. 1, 8 January 1999 (1999-01-08), pages 117 - 121, XP004259015, ISSN: 0014-5793
GARCIA-CALVO MARGARITA ET AL: "Inhibition of human caspases by peptide-based and macromolecular inhibitors.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, 4 December 1998 (1998-12-04), pages 32608 - 32613, XP002222060, ISSN: 0021-9258
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