USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE

Title:

USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE

Document Type and Number:

WIPO Patent Application WO2000012074

Kind Code:

A3

Abstract:

The invention is directed to methods to treat conditions mediated by kinase using compounds of formula (1) and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein Z is N or CR<1>, R<1> is a noninterfering substituent, each of X<1> and X<2> is a linker, Ar<1> and Ar<2> are identical or different, and represent optionally substituted C1-C20 hydrocarbyl residues wherein at least one of Ar<1> and Ar<2> is an optionally substituted aryl group, with the proviso that when X<2> is CH2 or an isostere thereof, X<1> is CO or an isostere thereof, and Ar<2> is optionally substituted phenyl, Ar<1> is other than an optionally substituted indolyl, benzimidazolyl or benzotriazolyl substituent, and wherein said optionally substituted phenyl is not an optionally substituted indolyl, benzimidazolyl, or benzotriazolyl, Y is a noninterfering substituent, wherein n is an integer from 0-4, and wherein m is an integer from 0-4 and 1 is an integer from 0-3.

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Inventors:

GOEHRING R RICHARD (US)
LUEDTKE GREGORY R (US)
MAVUNKEL BABU J (US)
CHAKRAVARTY SARVAJIT (US)
DUGAR SUNDEEP (US)
SCHREINER GEORGE F (US)
LIU DAVID Y (US)
LEWICKI JOHN A (US)

Application Number:

PCT/US1999/019845

Publication Date:

August 31, 2000

Filing Date:

August 27, 1999

Export Citation:

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Assignee:

SCIOS INC (US)
GOEHRING R RICHARD (US)
LUEDTKE GREGORY R (US)
MAVUNKEL BABU J (US)
CHAKRAVARTY SARVAJIT (US)
DUGAR SUNDEEP (US)
SCHREINER GEORGE F (US)
LIU DAVID Y (US)
LEWICKI JOHN A (US)

International Classes:

A61K31/00; A61K31/426; C07D277/20; A61K31/4365; A61K31/437; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/445; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/4965; A61K31/497; A61K31/506; A61K31/519; A61K31/522; A61K45/06; A61P1/04; A61P3/12; A61P9/00; A61P9/04; A61P11/00; A61P11/06; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P27/00; A61P29/00; A61P31/04; A61P43/00; C07D211/14; C07D277/52; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D409/06; C07D471/04; C07D471/10; C07D473/06; C07D495/04; (IPC1-7): A61K31/445; A61K31/495

Domestic Patent References:

WO1998028292A1	1998-07-02
WO1998006715A1	1998-02-19
WO1999061426A1	1999-12-02

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