Title:
USE OF PROTEASE-ACTIVATED RECEPTOR-2 INHIBITOR IN THE MANIFACTURE OF A MEDICAMENT FOR TREATING DELAYED HYPERSENSITIVITY
Document Type and Number:
WIPO Patent Application WO2003049723
Kind Code:
A8
Abstract:
The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.
Inventors:
TAKIZAWA TOSHIAKI (JP)
TAMIYA MASAKI (JP)
SAITO NAOHIRO (JP)
KANKE TORU (JP)
MATSUMOTO JIRO (JP)
WADA YASUSHI (JP)
KAWAGOE JUNICHI (JP)
FERRELL WILLIAM R (GB)
LOCKHART JOHN C (GB)
TAMIYA MASAKI (JP)
SAITO NAOHIRO (JP)
KANKE TORU (JP)
MATSUMOTO JIRO (JP)
WADA YASUSHI (JP)
KAWAGOE JUNICHI (JP)
FERRELL WILLIAM R (GB)
LOCKHART JOHN C (GB)
Application Number:
PCT/GB2002/005658
Publication Date:
April 15, 2004
Filing Date:
December 13, 2002
Export Citation:
Assignee:
KOWA CO (JP)
TAKIZAWA TOSHIAKI (JP)
TAMIYA MASAKI (JP)
SAITO NAOHIRO (JP)
KANKE TORU (JP)
MATSUMOTO JIRO (JP)
WADA YASUSHI (JP)
KAWAGOE JUNICHI (JP)
FERRELL WILLIAM R (GB)
LOCKHART JOHN C (GB)
TAKIZAWA TOSHIAKI (JP)
TAMIYA MASAKI (JP)
SAITO NAOHIRO (JP)
KANKE TORU (JP)
MATSUMOTO JIRO (JP)
WADA YASUSHI (JP)
KAWAGOE JUNICHI (JP)
FERRELL WILLIAM R (GB)
LOCKHART JOHN C (GB)
International Classes:
G01N33/50; A61K31/00; A61K45/00; A61K45/06; A61P1/04; A61P3/10; A61P11/06; A61P17/00; A61P19/02; A61P19/06; A61P21/04; A61P29/00; A61P31/06; A61P33/12; A61P35/00; A61P37/02; A61P37/06; A61P37/08; C12N15/09; C12Q1/02; G01N33/15; (IPC1-7): A61K31/00; A61K38/00; G01N33/50; C12Q1/37; G01N33/68
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