Title:
USE OF PYRROLOPYRIMIDINE COMPOUND IN TREATMENT OF ACUTE GRAFT VERSUS HOST DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/027790
Kind Code:
A1
Abstract:
Provided is the use of a pyrrolopyrimidine compound in the treatment of acute graft versus host disease, in particular the use of a compound of formula I, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof in the treatment of acute graft versus host disease.
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Inventors:
TU LIFAN (CN)
ZHANG XIQUAN (CN)
WANG XUNQIANG (CN)
YU DING (CN)
LI CHAOYI (CN)
ZHANG XIQUAN (CN)
WANG XUNQIANG (CN)
YU DING (CN)
LI CHAOYI (CN)
Application Number:
PCT/CN2023/110930
Publication Date:
February 08, 2024
Filing Date:
August 03, 2023
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/519; C07D487/04; A61P37/06
Domestic Patent References:
| WO2016095805A1 | 2016-06-23 | |||
| WO2021180093A1 | 2021-09-16 | |||
| WO2022268083A1 | 2022-12-29 |
Other References:
MARCUZZI ANNALISA, RIMONDI ERIKA, MELLONI ELISABETTA, GONELLI ARIANNA, GRASSO ANTONIO GIACOMO, BARBI EGIDIO, MAXIMOVA NATALIA: "New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib", PHARMACEUTICALS, M D P I AG, CH, vol. 15, no. 3, CH , pages 374, XP093135435, ISSN: 1424-8247, DOI: 10.3390/ph15030374
ABEDIN SAMEEM M., HAMADANI MEHDI: "Ruxolitinib: a potential treatment for corticosteroid refractory acute graft-versus-host disease", EXPERT OPINION ON INVESTIGATIONAL DRUGS, INFORMA HEALTHCARE, UK, vol. 29, no. 5, 3 May 2020 (2020-05-03), UK , pages 423 - 427, XP093135440, ISSN: 1354-3784, DOI: 10.1080/13543784.2020.1757069
ABEDIN SAMEEM, HAMADANI MEHDI: "Experimental Pharmaceuticals for Steroid-Refractory Acute Graft-versus-Host Disease", JOURNAL OF EXPERIMENTAL PHARMACOLOGY, DOVE MEDICAL PRESS, AUCKLAND, N.Z., vol. Volume 12, Auckland, N.Z. , pages 549 - 557, XP093135442, ISSN: 1179-1454, DOI: 10.2147/JEP.S259290
ABEDIN SAMEEM M., HAMADANI MEHDI: "Ruxolitinib: a potential treatment for corticosteroid refractory acute graft-versus-host disease", EXPERT OPINION ON INVESTIGATIONAL DRUGS, INFORMA HEALTHCARE, UK, vol. 29, no. 5, 3 May 2020 (2020-05-03), UK , pages 423 - 427, XP093135440, ISSN: 1354-3784, DOI: 10.1080/13543784.2020.1757069
ABEDIN SAMEEM, HAMADANI MEHDI: "Experimental Pharmaceuticals for Steroid-Refractory Acute Graft-versus-Host Disease", JOURNAL OF EXPERIMENTAL PHARMACOLOGY, DOVE MEDICAL PRESS, AUCKLAND, N.Z., vol. Volume 12, Auckland, N.Z. , pages 549 - 557, XP093135442, ISSN: 1179-1454, DOI: 10.2147/JEP.S259290
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