Title:
USE OF REAGENT FOR DETECTING EOSINOPHIL, EOSINOPHIL AND CYTOPLASM CONTENT THEREOF, AND HYDROXY DOCOSAHEXAENOIC ACID
Document Type and Number:
WIPO Patent Application WO/2024/065892
Kind Code:
A1
Abstract:
Provided is use of a reagent for detecting an eosinophil, an eosinophil and a cytoplasm content thereof, and a lipid metabolite hydroxy docosahexaenoic acid, which belongs to the technical field of medical treatment and medicines. Provided is use of the reagent for detecting an eosinophil in preparing a product for diagnosing pulmonary hypertension and/or determining the prognosis risk of pulmonary hypertension. By means of detecting the proportion of EOS in the peripheral blood, the diagnosis of pulmonary hypertension and the determination of the prognosis risk of pulmonary hypertension can be realized.
Inventors:
WANG JING (CN)
XING YANJIANG (CN)
SHU TING (CN)
ZHANG JIAWEI (CN)
XING YANJIANG (CN)
SHU TING (CN)
ZHANG JIAWEI (CN)
Application Number:
PCT/CN2022/125577
Publication Date:
April 04, 2024
Filing Date:
October 17, 2022
Export Citation:
Assignee:
INST BASIC MEDICAL SCIENCES CAMS (CN)
International Classes:
C12N5/0787; A61K31/202; A61K35/15
Foreign References:
| CN109266735A | 2019-01-25 | |||
| CN110295168A | 2019-10-01 | |||
| CN110478342A | 2019-11-22 | |||
| CN113884586A | 2022-01-04 | |||
| US20080146514A1 | 2008-06-19 | |||
| US20100113503A1 | 2010-05-06 |
Other References:
LARS HARBAUM;KAAJAM. BAASKE;MARCEL SIMON;TIM OQUEKA;CHRISTOPH SINNING;ANTONIA GLATZEL;NICOLE LüNEBURG;KARSTEN SYDOW;CARSTEN B: "Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension", BMC PULMONARY MEDICINE, BIOMED CENTRAL LTD, LONDON, UK, vol. 17, no. 1, 26 April 2017 (2017-04-26), London, UK , pages 1 - 9, XP021244463, DOI: 10.1186/s12890-017-0407-5
LI HONG-MEI: "Effect of Docosahexaenoic Acid on the Expression of NFATc1 in Pulmonary Hypertension Rats", CHINESE JOURNAL OF ARTERIOSCLEROSIS, vol. 23, no. 9, 17 July 2015 (2015-07-17), pages 865 - 869, XP093153727
YAEGER, M. J. ET AL.: "Docosahexaenoic Acid Supplementation Reduces Ozone-induced Lung inflammation", THE TOXICOLOGIST SUPPLEMENT TO TOXICOLOGICAL SCIENCES, vol. 186, no. S1, 22 March 2022 (2022-03-22)
RUI CHEN: "Docosahexaenoic acid inhibits monocrotaline-induced pulmonary hypertension via attenuating endoplasmic reticulum stress and inflammation", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 314, 1 February 2018 (2018-02-01), US , pages 1243 - 1255, XP093153746, ISSN: 1040-0605, DOI: 10.1152/ajplung.00046.2017
QI XIAN-MEI: "Advances in metabolic reprogramming in pathogenesis of pulmonary hypertension", CHINESE JOURNAL OF PATHOPHYSIOLOGY, ZHONGGUO BINGLI SHENGLI XUEHUI, BEIJING, CN, vol. 37, no. 11, 25 November 2021 (2021-11-25), CN , pages 2062 - 2071, XP093153755, ISSN: 1000-4718, DOI: 10.3969/j.issn.1000-4718.2021.11.020
TING SHU: "Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA", EUROPEAN RESPIRATORY JOURNAL, EUROPEAN RESPIRATORY SOCIETY, ENGLAND, vol. 61, no. 3, 1 March 2023 (2023-03-01), England, pages 2200582, XP093153766, Retrieved from the Internet DOI: 10.1183/13993003.00582-2022
LI HONG-MEI: "Effect of Docosahexaenoic Acid on the Expression of NFATc1 in Pulmonary Hypertension Rats", CHINESE JOURNAL OF ARTERIOSCLEROSIS, vol. 23, no. 9, 17 July 2015 (2015-07-17), pages 865 - 869, XP093153727
YAEGER, M. J. ET AL.: "Docosahexaenoic Acid Supplementation Reduces Ozone-induced Lung inflammation", THE TOXICOLOGIST SUPPLEMENT TO TOXICOLOGICAL SCIENCES, vol. 186, no. S1, 22 March 2022 (2022-03-22)
RUI CHEN: "Docosahexaenoic acid inhibits monocrotaline-induced pulmonary hypertension via attenuating endoplasmic reticulum stress and inflammation", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 314, 1 February 2018 (2018-02-01), US , pages 1243 - 1255, XP093153746, ISSN: 1040-0605, DOI: 10.1152/ajplung.00046.2017
QI XIAN-MEI: "Advances in metabolic reprogramming in pathogenesis of pulmonary hypertension", CHINESE JOURNAL OF PATHOPHYSIOLOGY, ZHONGGUO BINGLI SHENGLI XUEHUI, BEIJING, CN, vol. 37, no. 11, 25 November 2021 (2021-11-25), CN , pages 2062 - 2071, XP093153755, ISSN: 1000-4718, DOI: 10.3969/j.issn.1000-4718.2021.11.020
TING SHU: "Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA", EUROPEAN RESPIRATORY JOURNAL, EUROPEAN RESPIRATORY SOCIETY, ENGLAND, vol. 61, no. 3, 1 March 2023 (2023-03-01), England, pages 2200582, XP093153766, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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