Title:
USE OF REGULATOR OF ITPRIPL1 IN PREPARATION OF DRUG THAT REGULATES IMMUNE RESPONSES OR FIGHTS TUMORS
Document Type and Number:
WIPO Patent Application WO/2022/089557
Kind Code:
A1
Abstract:
Provided is a use of a regulator of ITPRIPL1 in the preparation of a drug that regulates immune responses or fights tumors, the regulator being used to increase or decrease the expression or function of the ITPRIPL1 gene or protein in an organism. Also provided is a pharmaceutical composition, which comprises the regulator used in the use. Also disclosed are an isolated ITPRIPL1 recombinant protein and an antibody that recognizes and binds to the ITPRIPL1. On the basis of the principle that an ITPRIPL1 protein binds to CD3ε and NRP2 receptors to regulate the functions of different immune cells, and then participates in the regulation of immune responses and a process of immune evasion of a tumor, it is confirmed that a regulator of ITPRIPL1 may be used to prepare a drug or a pharmaceutical composition, and may be applied to suppress tumors, autoimmune disease, transplant rejection, allergies, infections and other diseases.
Inventors:
XU JIE (CN)
DENG SHOUYAN (CN)
SONG TENG (CN)
WANG YITING (CN)
WANG YUNGANG (CN)
WANG HUANBIN (CN)
CHI HAO (CN)
DENG SHOUYAN (CN)
SONG TENG (CN)
WANG YITING (CN)
WANG YUNGANG (CN)
WANG HUANBIN (CN)
CHI HAO (CN)
Application Number:
PCT/CN2021/127234
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07K16/30; A61K39/00; A61P35/00; C07K19/00; C12N15/13; C12N15/62
Domestic Patent References:
| WO2020092455A2 | 2020-05-07 | |||
| WO2003048731A2 | 2003-06-12 |
Foreign References:
| US20190161806A1 | 2019-05-30 | |||
| CN111655869A | 2020-09-11 | |||
| CN202011191447A | 2020-10-30 | |||
| CN202110566040A | 2021-05-24 |
Other References:
LI RUI, YANG YI-E, YIN YUN-HONG, ZHANG MENG-YU, LI HAO, QU YI-QING: "Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 17, no. 1, 1 December 2019 (2019-12-01), XP055926979, DOI: 10.1186/s12967-019-2068-z
DAUSINAS PAIGE; PULAKANTI KIRTHI; RAO SRIDHAR; COLE JENNIFER M.; DAHL RICHARD; COWDEN DAHL KAREN D.: "ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells", GENE, ELSEVIER AMSTERDAM, NL, vol. 738, 13 February 2020 (2020-02-13), NL , XP086093470, ISSN: 0378-1119, DOI: 10.1016/j.gene.2020.144458
DATABASE NUCLEOTIDE 13 February 2021 (2021-02-13), ANONYMOUS : "Homo sapiens ITPRIP like 1 (ITPRIPL1), transcript variant 5, mRNA ", XP055926982, retrieved from NCBI Database accession no. NM_001324490
KUNG, P., SCIENCE, vol. 206, 1979, pages 347 - 349
SALMERON, A., J IMMUNOL, vol. 147, 1991, pages 3047 - 3052
CALLARD, RE, CLIN EXP IMMUNOL, vol. 43, 1981, pages 497 - 505
PESSANO, S., EMBO J, vol. 4, 1985, pages 337 - 344
CONRAD M.L., CYTOMETRY A, vol. 71, 2007, pages 925 - 933
AM J PHYSIOL LUNG CELL MOL PHYSIOL., 2018
SOHINI ROY, CANCER RES., 2018
S SCHELLENBURG, MOL IMMUNOL, 2017
LIU X, CELL REP., 2016
RIZZOLIO, S., CANCER RESEARCH, 2017
SAMBROOKRUSSELL: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PRESS
CHOTHIA, NATURE, vol. 342, 1989, pages 877 - 883
AL-LAZIKANI: "Standard conformations for the canonical structures of immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, 1997, pages 927 - 948, XP004461383, DOI: 10.1006/jmbi.1997.1354
KABAT: "Sequences of Protein of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
"NCBI", Database accession no. NM - 001008949.3
A A STEPANENKO, GENE, vol. 569, no. 2, 15 September 2015 (2015-09-15), pages 182 - 90
HIRA S., J PHYSIOL SCI., vol. 69, no. 5, September 2019 (2019-09-01), pages 723 - 732
KESKITALO S, FRONT IMMUNOL, vol. 10, 5 December 2019 (2019-12-05), pages 2770
YI GAO, INT J CLIN EXP MED, vol. 7, no. 11, 2014, pages 4572 - 4583
LORBER, MARC I, TRANSPLANTATION, vol. 67, no. 6, 1999, pages 897 - 903
PABOIS A, BIOCHEM PHARMACOL, vol. 104, 15 March 2016 (2016-03-15), pages 95 - 107
ISMAIL CEM YILMAZ, ALLERGY, 14 September 2021 (2021-09-14)
ELIZABETH A REAP, VACCINE, vol. 25, no. 42, 16 October 2007 (2007-10-16), pages 7441 - 9
YOSHIKAWA N., HORM METAB RES, vol. 26, no. 9, September 1994 (1994-09-01), pages 419 - 23
TRANSPLANT PROC, vol. 48, no. 8, October 2016 (2016-10-01), pages 2840 - 2844
HAR-NOY M, J TRANSL MED, vol. 18, no. 1, 12 May 2020 (2020-05-12), pages 196
NAKAMURA-HOSHI M, SCI REP, vol. 10, no. 1, 9 July 2020 (2020-07-09), pages 11394
ZHUANG X, CANCER IMMUNOL RES, vol. 7, no. 6, June 2019 (2019-06-01), pages 939 - 951
DAUSINAS PAIGE; PULAKANTI KIRTHI; RAO SRIDHAR; COLE JENNIFER M.; DAHL RICHARD; COWDEN DAHL KAREN D.: "ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells", GENE, ELSEVIER AMSTERDAM, NL, vol. 738, 13 February 2020 (2020-02-13), NL , XP086093470, ISSN: 0378-1119, DOI: 10.1016/j.gene.2020.144458
DATABASE NUCLEOTIDE 13 February 2021 (2021-02-13), ANONYMOUS : "Homo sapiens ITPRIP like 1 (ITPRIPL1), transcript variant 5, mRNA ", XP055926982, retrieved from NCBI Database accession no. NM_001324490
KUNG, P., SCIENCE, vol. 206, 1979, pages 347 - 349
SALMERON, A., J IMMUNOL, vol. 147, 1991, pages 3047 - 3052
CALLARD, RE, CLIN EXP IMMUNOL, vol. 43, 1981, pages 497 - 505
PESSANO, S., EMBO J, vol. 4, 1985, pages 337 - 344
CONRAD M.L., CYTOMETRY A, vol. 71, 2007, pages 925 - 933
AM J PHYSIOL LUNG CELL MOL PHYSIOL., 2018
SOHINI ROY, CANCER RES., 2018
S SCHELLENBURG, MOL IMMUNOL, 2017
LIU X, CELL REP., 2016
RIZZOLIO, S., CANCER RESEARCH, 2017
SAMBROOKRUSSELL: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PRESS
CHOTHIA, NATURE, vol. 342, 1989, pages 877 - 883
AL-LAZIKANI: "Standard conformations for the canonical structures of immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, 1997, pages 927 - 948, XP004461383, DOI: 10.1006/jmbi.1997.1354
KABAT: "Sequences of Protein of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
"NCBI", Database accession no. NM - 001008949.3
A A STEPANENKO, GENE, vol. 569, no. 2, 15 September 2015 (2015-09-15), pages 182 - 90
HIRA S., J PHYSIOL SCI., vol. 69, no. 5, September 2019 (2019-09-01), pages 723 - 732
KESKITALO S, FRONT IMMUNOL, vol. 10, 5 December 2019 (2019-12-05), pages 2770
YI GAO, INT J CLIN EXP MED, vol. 7, no. 11, 2014, pages 4572 - 4583
LORBER, MARC I, TRANSPLANTATION, vol. 67, no. 6, 1999, pages 897 - 903
PABOIS A, BIOCHEM PHARMACOL, vol. 104, 15 March 2016 (2016-03-15), pages 95 - 107
ISMAIL CEM YILMAZ, ALLERGY, 14 September 2021 (2021-09-14)
ELIZABETH A REAP, VACCINE, vol. 25, no. 42, 16 October 2007 (2007-10-16), pages 7441 - 9
YOSHIKAWA N., HORM METAB RES, vol. 26, no. 9, September 1994 (1994-09-01), pages 419 - 23
TRANSPLANT PROC, vol. 48, no. 8, October 2016 (2016-10-01), pages 2840 - 2844
HAR-NOY M, J TRANSL MED, vol. 18, no. 1, 12 May 2020 (2020-05-12), pages 196
NAKAMURA-HOSHI M, SCI REP, vol. 10, no. 1, 9 July 2020 (2020-07-09), pages 11394
ZHUANG X, CANCER IMMUNOL RES, vol. 7, no. 6, June 2019 (2019-06-01), pages 939 - 951
Attorney, Agent or Firm:
SHANGHAI WANLIN PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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