The invention relates to the use of ruthenium complexes acting as catalysts and/or precatalysts in the olefin metathesis reaction.

A number of ruthenium complexes are known in the art that allow to obtain internal olefins [R. H. Grubbs (Ed.), AG Wenzel (Ed.), D. J. O'Leary (Ed.), E. Khosravi (Ed.), Handbook of Olefin Metathesis, 2nd edition, 3 Volumes, 2015, John Wiley & Sons, Inc. 1608 pages], among which one should note the 1 st, 2nd and 3rd generations, and complexes comprising two, identical or different, N-heterocyclic carbene ligands (NHCs). In ruthenium complexes, the active, 14-electron catalyst form comprises a neutral ligand that is a phosphine or NHC [Grubbs et al. Chem. Rev. 2010, 110, 1746-1787; Nolan et al. Chem. Commun. 2014, 50, 1 0355-10375].

(Herrmann)

The most versatile and effective complexes are those of the 2nd generation - the so-called Grubbs catalysts (Gru-ll), Hoveydy-Grubbs (Hov-ll) and Indenylidene (Indium II), i.e. those that contain one NHC type ligand in their structure.

Cross-metathesis (CM) reaction with acrylonitrile (and its derivatives) is one of the most demanding olefin metathesis processes, since acrylonitrile is considered to be the type 3 olefin in metathesis reactions [no homodimerisation - J. Am. Chem. Soc, 2003, 125, 1 1360-1 1370]. On the other hand, CM of acrylonitrile with unsaturated esters, amides or other nitriles leads to the formation of bifunctional molecules with a considerable added value. For example, products of the CM of acrylonitrile with medium chain length esters containing a C=C terminal bond or with unsaturated fatty acid esters may be used to obtain aminoesters - monomers for the production of polyamids [Bruneau, P. H. Dixneuf et al., ChemSusChem, 2012, 5, 1410-1414, DOI :10.1002/cssc.201200086]. The most effective catalysts in an industrially significant cross-metathesis reaction with acrylonitrile [S. J. Connon and S. Blechert, Chem. Int. Ed. 2003, 42, 1900-1 923, DOI:10.1002/anie.200200556], are Hov-ll catalysts; even these complexes, however, allow for obtaining the maximum turn over number w (TON) of as little as 13,000 [Monatsh. Chem., 2015, 146, 1 107-1 1 13, DOI : 10.1007 / S00706-015-1480-1 ] which prevents this methodology from being industrially used. Steric or electron modifications of Hov-ll complexes did not produce a powerful improvement in CM with acrylonitrile. The inability to significantly improve the efficiency of complexes of ruthenium with NHC (expressed as TON) in reactions leading to the formation of internal C=C bonds is a substantial problem in the art.

According to the state of the art, ruthenium complexes containing a cyclic alkyl amino carbene ligand (CAAC) are used for obtaining terminal olefins in the way of cross-metathesis reaction with ethylene. At the stage of early work, Grubbs and Bertrand used standard ring closing metathesis (RCM) to evaluate the activity of the obtained CAAC ruthenium complexes [Angew. Chem., Int. Ed., 2007, 46, 7262-7265], using high volumes (1 -5 mol%) of the catalyst. In the latest reports, the same authors determine the reactivity of the new ruthenium complexes containing the CAAC ligand by measuring the rate of their reaction with vinyl ether and do not attempt to synthesize the internal C=C bonds [US20140309433A1 , Angew. Chem. Int. Ed., 2015, 54, 1919-1923]. Other authors attempted to modify the CAAC ligand framework by introducing a sterically crowded isopropyl substituent into the main ring [Zhang, Shi et al, Chem. Commun., 2013, 49, 9491 -9493, DOI :10.1039/C3CC45823G]. Authors of this report used a high ruthenium complex load in the RCM reaction.

It is also known that CAAC ligand-containing ruthenium complexes show a significantly greater degree of non-productive metathesis compared to most NHC-containing complexes [J. Am. Chem. Soc. 2010, 132, 8534-8535, DOI :10.1021 /ja1029045]. This is an undesirable characteristic in the synthesis of internal C=C bonds. Considering the current state of the art, it is therefore non-obvious to use the CAAC ruthenium complexes to obtain (in an economically advantageous manner) compounds containing an internal C=C bond.

In 2003, S. Blechert and others observed an advantageous effect of adding copper salt (I) on CM reactions catalyzed by Gru-ll complexes with acrylonitrile [Eur. J. Org. Chem. 2003, 2225-2228, DOI:10.1002/ejoc.200300215]. The authors attributed the advantageous effect of the addition of copper salt (I) on the result of the CM reaction to the effect of scavenging phosphine from the reaction mixture and binding it into an insoluble complex.

In 201 1 , P. Dixneuf and Ch. Bruneau [Green Chem., 2011 , 13, 2258-2271 , DOI :10.1039/C1 GC1 5377C] have attempted to utilise products of ethenolysis of vegetable oils in acrylonitrile reactions producing raw materials that contained nitrogen. Other attempts to utilise vegetable oil metathesis products have been described by the same authors in their next paper [Green Chem., 201 1 , 13, 291 1 -2919, DOI : 10.1039 / C1 GC15569E], in which they subjected vegetable oil derivatives to various CM reactions with acrylonitrile and acrolein.

Yet another approach to obtaining compounds having two nitrile moieties in the molecule has been presented by Ch. Bruneau et al. [Monatsh. Chem., 2015, 146, 1 107-1 1 13, DOI:10.1007/s00706-01 5- 1480-1 ] CM reactions were carried out with acrylonitrile and 1 0-undecenonitrile in the presence of commercially available ruthenium complexes. Hitherto, for demanding CM reactions with acrylonitrile, no ruthenium complexes have been identified that would allow using that process on an industrial scale, with high yields and favorable selectivities.

Authors of papers and authors of the inventions cited above emphasise the positive effect of reduced substrate concentration (high dilution of C <0.1 M was used) on the reaction yield.

To sum up the state of the art, a substantial problem is posed by low efficiency (expressed as the TON value) in reactions that lead to the formation of internal C=C bonds. A particular case of a demanding reaction with high industrial potential is the CM with acrylonitrile, for which there are currently no alternative tools (in the form of more efficient homogeneous ruthenium catalysts) that would allow for improving the yield while maintaining a high selectivity of the process.

It has been observed that in the presence of selected CAAC-ruthenium complexes the CM reactions with acrylonitrile are characterised by a very high TON even at a concentration of 1 M, which can result in a significant reduction in process costs.

Surprisingly, it has been observed that CAAC ruthenium complexes promote the formation of internal C=C bonds with the catalyst loading of <0.1 mol%, and in some cases at <0.002 mol%.

Furthermore, it has been surprisingly found that the CAAC ligand structure has a key effect on the efficiency and selectivity of CM reactions with vinyl derivatives containing electron deficient partners (EDP), such as methyl acrylate or acrylonitrile.

It has been shown that ruthenium complexes containing CAAC ligands with the general formula 1 , 1a show higher efficiency in forming internal C=C internal bonds than the complexes containing NHC ligand of formula 1 b. In addition, the complexes containing ligand 1 have been shown to be much more effective and selective in CM reactions with acrylonitrile than analogs containing CAAC ligands with the general formula 1a and than NHC-containing complexes of formula 1 b.

1 1a 1b

It has also been observed that substituents in the Ar ¹ group greatly affect the efficiency and selectivity in CM reactions with EDP. Grubbs and Bertrand describe the superior efficiency of the 2aa and 2ab complexes in the ethenolysis reaction of meth l oleate leading to the formation of two terminal olefins.

Surprisingly, in the CM reactions with EDP, the 2aa complex was significantly less efficient and selective than the complexes containing the Ar ¹ moiety substituted in ortho positions with small or medium alkyl groups (Me, Et), such as the 2bc and 2bd complexes. Nevertheless, the phenyl substituent at the quaternary carbon atom made the 2aa com lex more efficient and selective than the 2ab complex.

NHC ruthenium complexes containing at the nitrogen atoms of the NHC ligand a phenyl ring substituted in the ortho position with isopropyl groups (the so-called SIPr ligand) show very good activity and efficiency in the formation of internal C=C bonds. Similarly, benzylidene ruthenium CAAC complexes in which the nitrogen atom is substituted with 2,6-diisopropylphenyl show good and very good efficiency in the ethenolysis reaction. Surprisingly, a very low activity and efficiency of the CAAC complexes containing isopropyl groups in the ortho position of the Ar ¹ have been observed in the reactions of the formation of internal C=C bonds. This activity is slightly increased at increased temperatures. For benzylidene CAAC complexes, a change in the activity is observed upon introduction of respective functional groups into the benzylidene ligand ring, known from benzylidene NHC complexes, is observed [for example: Angew. Chem. Int. Ed, 2002, 41 (21), 4038-4040].

Another advantage of the ruthenium complexes of the invention is the superior selectivity in the reaction of acrylonitrile and an internal olefin. In a reaction of an asymmetrical internal olefin (e.g. of methyl oleate (MO) with acrylonitrile, the formation of two CM products with acrylonitrile, two CM products with ethylene and two MO homometathesis products is observed. The MO homomethasis products are the least desirable by-product, as they have less industrial applications than the terminal olefins, and their re- introduction to the process is unfavourable due to the reduced reactivity of internal olefins having a substantial ratio of the trans isomer. The complexes of the invention in the reaction of MO with acrylonitrile lead to the formation of homometathesis products in a quantity that is several fold lower.

Disclosure of the essence of the invention

The application, therefore, relates to the use of a compound of formula 2,

wherein: X ¹ and X ² are each an anionic ligand;

G is a halogen atom or a substituent selected from OR', SR', S(0)R', S(0) ₂ R' N(R')(R"), P(R')(R")(R"'), where R', R" and R'" are the same or different C _r C ₂ 5 alkyl group, C ₃ -C ₁₂ cycloalkyl group, 0^0 ₂₅ alkoxy group, C ₂ -C ₂₅ alkenyl group, C^C^ perfluoroalkyl, C ₅ -C ₂₀ aryl, C ₅ -C ₂₄ aryloxy, C ₂ -C ₂₀ heterocyclyl, C ₄ -C ₂₀ , heteroaryl, C ₅ -C ₂ o, or which may involve the formation of a substituted or non-substituted cyclic C ₄ -Ci ₀ or policyclic C4-C12 systems, which are optionally substituted with at least one C1 -C12 alkyl, C1 -C12 perfluoroalkyl, C^C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₂ -C ₂₀ heterocyclyl , C ₄ -C ₂₀ heteroaryl , C ₅ -C ₂₀ heteroaryloxy, may also be substituted with an ester (-COOR'), amide (-CONR' ₂ ), formyl (-CHO), ketone (-COR'), hydroxamic (-CON(OR')(R')) groups, wherein R' is ( C12 alkyl, C3-C12 cycloalkyl , C ₂ -Ci ₂ alkenyl , C ₅ -C ₂ o aryl, which are optionally substituted with at least one C1 -C12 alkyl, C1 -C12 perfluoroalkyl, C1 -C12 alkoxy, C5-C20 aryl, C ₅ -C ₂₄ aryloxy, C ₇ -C ₂₄ aralkyl, C ₂ -C ₂ o heterocycle, C ₄ -C ₂ o, heteroaryl, C ₅ -C ₂ o heteroaryloxy, or a halogen atom ;

Ar is an aryl group that is substituted by hydrogen atoms, or optionally is substituted by at least one C _r C ₁₂ alkyl, C^C^ perfluoroalkyl, C^C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₂ -C ₂₀ heterocyclic, C ₄ -C ₂₀ heteroaryl, C ₅ - C ₂₀ heteroaryloxy, C ₇ -C ₂₄ aralkyl , C ₅ -C ₂₄ perfluoroaryl groups, or a halogen atom ;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom , a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-P(0)(OR') ₂ ) phosphonium group, a (-P(O)R'(OR')) phosphinium group, a (-P(OR') ₂ ) phosphonous group, a (-PR'2) phosphine group, a (-N0 ₂ ) nitro group, a (-NO) nitroso group, a (-COOH) carboxy group, a (-COOR') ester group, a (-CHO) formyl group, a (-COR') ketone group, a -NC(0)R' group, an amino group, an ammonium group, a (-OMe) alkoxy group, in which groups R' is C C ₅ alkyl, C C ₅ perfluoroalkyl , C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl , C ₄ -C ₂₀ heteroaryl, C ₅ -C ₂₀ heteroaryloxy, and wherein R ¹ , R ² , R ³ and R ⁴ may be interconnected to form a cyclic system ;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or a C1 -C25, alkyl, C3-C12 cycloalkyl, C1 -C5 perfluoroalkyl, C ₂ - C ₁₂ alkenyl, C ₅ -C ₂₀ , aryl C ₅ -C ₂₄ aryloxy, C ₂ -C ₂₀ heterocycle, C ₄ -C ₂₀ heteroaryl, C ₅ -C ₂₀ heteroaryloxy, C ₇ -C ₂₄ aralkyl C ₅ -C ₂₄ , which are optionally substituted by at least one C^C^ alkyl, C^C^, perfluoroalkyl, _! -0 ₁₂ alkoxy, C ₅ -C ₂₄ aryloxy, C ₄ -C ₂₀ heteroaryl, C ₅ -C ₂₀ heteroaryloxy or a halogen atom ; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system ;

in olefin metathesis reactions where at least one compound is formed as the main product containing at least one non-terminal double C==C bond, involving the process of contacting at least one type of olefin i n the presence of a compound of formula 2.

Preferably, said compound is represented by formula 2

2

wherein:

X ¹ and X ² are halogen atoms,

G is a halogen atom or a substituent selected from the OR', N(R')(R") group, wherein R' and R" are the same or different C ₁ -C ₁₂ alkyl, C3-C ₁₂ cykloalkyl, C ₂ -Ci ₂ alkenyl, C ₅ -C ₂ o aryl, which are optionally substituted by at least one Ci-Ci ₂ alkyl, Ci-Ci ₂ perfluoroalkyl, Ci-Ci ₂ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom, a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-P(0)(OR') ₂ ) phosphonium group, a (-P(O)R'(OR')) phosphinium group, a (-P(OR') ₂ ) phosphonous group, a (-PR' ₂ ) phosphine group, a (-N0 ₂ ) nitro group, a (-NO) nitroso group, a (-COOH) carboxy group, a (-COOR') ester group, a (-CHO) formyl group, a (-COR') ketone group, a -NC(0)R' group, an amino group, an ammonium group, a (-OMe) alkoxy group, in which groups R' is C C ₅ alkyl, C C ₅ perfluoroalkyl, C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or an C^C^ alkyl, a C ₃ -C ₁₂ cykloalkyl, a C ₂ -C ₁₂ alkenyl, a C ₅ -C ₂₀ aryl, a C^Cs perfluoroalkyl, a C ₇ -C ₂₄ aralkyl, a C ₅ -C ₂₄ perfluoroaryl groups, which are optionally substituted by at least one 0 _Γ 0 ₁₂ alkyl, 0 _Γ 0 ₁₂ perfluoroalkyl, 0 _Γ 0 ₁₂ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy, or a halogen atom; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system

Preferably, said compound is represented by formula 2

2

wherein:

6 X ¹ and X ² are halogen atoms,

G is a halogen atom or a substituent selected from theOR', N(R')(R") group, wherein R' is C _r C ₁₂ alkyl, C ₃ -C ₁₂ cykloalkyl, C ₅ -C ₂₀ aryl, which are optionally substituted by at least one C^C^ alkyl, C^C^ perfluoroalkyl, C^C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom, a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-N0 ₂ ) nitro group, a (-COOR') ester group, a (-COR') ketone group, a -NC(0)R' group, an amino group, an ammonium group, a (-OMe) alkoxy group, in which groups R' is C _r C ₅ alkyl, C -C ₅ perfluoroalkyl, C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or an Ci-C ₂₅ alkyl, a C ₃ -Ci ₂ cykloalkyl, a C ₅ -C ₂₀ aryl, a C ₇ -C ₂₄ aralkyl, which are optionally substituted by at least one Ci-Ci ₂ alkyl, Ci-Ci ₂ perfluoroalkyl, Ci-Ci ₂ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy, or a halogen atom ; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system

Preferably, said compound is represented by formula 2

2

wherein:

X is an atom of chlorine or iodine

G is a halogen atom or a substituent selected from a OR', N(R')(R") group, wherein R' is C _r C ₁₂ alkyl, C ₃ -C ₁₂ cykloalkyl, C ₅ -C ₂₀ aryl, which are optionally substituted by at least one C^C^ alkyl, CrC^perfluoroalkyl, C^C^ alkoxy, C ₅ -C ₂₄ , aryloxy, C ₅ -C ₂₀ heteroaryloxy;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom, a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-N0 ₂ ) nitro group, a (-COOR') ester group, a (-COR') ketone group, a -NC(0)R' group, an amino group, an ammonium group, a (-OR') alkoxy group, in which groups R' is C C ₅ alkyl, C ₁ -C5 perfluoroalkyl, C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or a Ci-C ₂₅ alkyl, C ₃ -Ci ₂ cykloalkyl, C ₅ -C ₂₀ aryl, C ₇ -C ₂₄ aralkyl, which are optionally substituted by at least one C^C^ alkyl C^C^ perfluoroalkyl, C^C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ , heteroaryloxy, or a halogen atom; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system; R ^{1 1} , R ¹² , R ¹³ , R ¹⁴ and R ¹⁵ are each a hydrogen atom, a halogen atom, a C C ₂ 5 alkyl group, a C ₃ -C cykloalkyl group, a C C ₂ 5 alkoxy group, a C ₅ -C ₂₄ perfluoroaryl group, C ₅ -C ₂₀ heteroaryl group or a C ₂ -C alkenyl group, and wherein the substituents R ² , R ² , R ³ , R ³ and R ⁴ may be interconnected to form substituted or non-substituted cyclic C ₄ -C ₁₀ or policyclic C ₄ -C ₁₂ system.

Preferably, said compound is represented by formula 2

2

wherein:

X is an atom of chlorine or iodine

G is a halogen atom or a substituent selected from OR', N(R')(R"), wherein R' is C _r C ₁₂ alkyl, C ₃ -C ₁₂ cykloalkyl, C ₅ -C ₂₀ aryl, which are optionally substituted by at least one Ci-Ci ₂ alkyl, Ci-Ci ₂ perfluoroalkyl, alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom, a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-N0 ₂ ) nitro group, a (-COOR') ester group, a (-COR') ketone group, a -NC(0)R' group, an amino group, an ammonium group, a (-OMe) alkoxy group, in which groups R' is C C ₅ alkyl, C ₁ -C5 perfluoroalkyl, C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or a Ci-C ₂₅ alkyl, C ₃ -Ci ₂ cykloalkyl, C ₅ -C ₂₀ aryl, C ₇ -C ₂₄ aralkyl groups, which are optionally substituted by at least one C^C^ alkyl, C C^ perfluoroalkyl, C C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy, or a halogen atom ; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system

R ^{1 1} and R ¹⁵ are each methyl, ethyl or isopropyl

R ¹² , R ¹³ , R ¹⁴ are each a hydrogen atom, a Ci-C ₂₅ alkyl group,

Preferably, said compound is represented by formula 2

2

wherein:

X is an atom of chlorine or iodine

G is a halogen atom or a substituent selected from OR', N(R')(R"), wherein R' is C^C^ alkyl, C ₃ -Ci ₂ cykloalkyl, C ₅ -C ₂ o aryl, which are optionally substituted by at least one C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ perfluoroalkyl, alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy;

R ¹ , R ² , R ³ , R ⁴ are each a hydrogen atom, a (-S(O)R') sulphoxide group, a (-S0 ₂ NR' ₂ ) sulphonamide group, a (-N0 ₂ ) nitro group, a (-COOR') ester group, a (-COR') ketone group, a -NC(0)R' group, an ammonium group, a (-OMe) alkoxy group, in which groups R' is C _r C ₅ alkyl, C -C ₅ perfluoroalkyl, C ₅ -C ₂₄ aryl, C ₇ -C ₂₄ aralkyl, C ₅ -C ₂₄ perfluoroaryl;

R ⁵ , R ⁶ , R ⁷ and R ⁸ are each a hydrogen atom or a C^C^ alkyl, C ₅ -C ₂₀ aryl groups, which are optionally substituted by at least one C^C^ alkyl, C C^ perfluoroalkyl, C C^ alkoxy, C ₅ -C ₂₄ aryloxy, C ₅ -C ₂₀ heteroaryloxy, or a halogen atom; and wherein R ⁵ and R ⁶ and/or R ⁷ and R ⁸ may be interconnected to form a cyclic system

R ^{1 1} and R ¹⁵ are each methyl or ethyl ;

R ¹² , R ¹³ , R ¹⁴ are each a hydrogen atom, a Ci-C ₂₅ alkyl group.

Preferably, the intercontacted olefins contain at least one nitrile moiety.

Preferably, one of the intercontacted olefins is acrylonitrile.

Preferably, an olefin containing at least one nitrile moiety is used in the cross-metathesis (CM) reaction.

Preferably, acrylonitrile is used in an amount of from 1 to 6 equivalents of the second olefin.

Preferably, acrylonitrile is used in an amount of from 1 .05 to 2 equivalents of the second olefin.

Preferably, the reaction is conducted in an organic solvent such as toluene, benzene, mesitylene, dichloromethane, ethyl acetate, methyl acetate, tertbutyl methyl ether, cyclopentylmethyl ether, or with no solvent.

Preferably, the reaction is conducted at a temperature of from 20 to 150°C.

Preferably, the reaction is conducted at a temperature of from 40 to 120 °C. Preferably, the reaction is conducted at a temperature of from 40 to 90 °C.

Preferably, the reaction is conducted over from 5 minutes to 24 hours.

Preferably, compound 2 is used in an amount of less than 0.1 mol%.

Preferably, compound 2 is added to the reaction mixture in portions and/or continuously using a pump.

Preferably, compound 2 is added to the reaction mixture as a solid and/or as a solution in an organic solvent.

Preferably, acrylonitrile is added to the reaction mixture in portions and/or continuously using a pump.

Preferably, the gaseous by-product of the reaction (ethylene, propylene, butylene) is actively removed from the reaction mixture using an inert gas or vacuum.

The invention will be presented in greater detail in preferred embodiments, with reference to the accompanying drawings, in which :

Fig. 1 shows the summary of olefin metathesis precatalysts and/or catalysts used according to the present invention.

Terms

The terms used in the present description have the meanings as follows. Non -defined terms in this document have the meaning given and understood by a person skilled in the art in the light of the best knowledge held, of the present disclosure, and of the context of the description of the patent application. Unless it is indicated otherwise, the following conventional chemistry terms are used the present description that have the meanings as defined below.

The term„halogen atom" or„halogen" refers to an element selected from F, CI, Br, I.

The term„carbene" refers to a particle containing a neutral carbon atom with a valence number of two and having two unpaired (triplet state) or paired (singlet state) valence electrons. The term„carbene" also includes carbene analogs in which the carbon atom is substituted by another chemical element such as boron, silicon, germanium, tin, lead, nitrogen, phosphorus, sulphur, selenium and tellurium.

The term„alkyf refers to a saturated, linear or branched hydrocarbon substituent having the indicated number of carbon atoms. Examples of alkyl substituents include -methyl, -ethyl, -n-propyl, -n-butyl, -n- pentyl, -n-hexyl, -n-heptyl, -n- octyl, n-nonyl, and -n-decyl. Representative branched-(C C ₀ )alkyls include -isopropyl, -sec-butyl, -isobutyl, -tert-butyl, -isopentyl, -neopentyl, -1 -methylobutyl, -2- methylobutyl, -3-methylobutyl, -1 ,1 -dimethylopropyl, -1 ,2-dimethylopropyl, -1 -methylopentyl, -2- methylopentyl, -3-methylopentyl, -4-methylopentyl, -1 -ethylobutyl, -2-ethylobutyl, -3-ethylobutyl, -1 ,1 - dimethylobutyl, -1 ,2-dimethylobutyl, 1 ,3-dimethylobutyl, -2,2-dimethylobutyl, -2,3-dimethylobutyl, -3,3- dimethylobutyl, -1 -methylohexyl, 2-methylohexyl, -3-methylohexyl, -4-methylohexyl, -5-methylohexyl, -1 ,2- dimethylopentyl, -1 ,3-dimethylopentyl, -1 ,2-dimethylohexyl, -1 ,3-dimethylohexyl, -3,3-dimethylohexyl, 1 ,2- dimethyloheptyl, -1 ,3-dimethyloheptyl, -3,3-dimethyloheptyl and the like.

The term„alkoxy" refers to an alkyl substituent as defined above bound by an oxygen atom.

The term„perfluoroalkyl" refers to an alkyl group as defined above in which all the hydrogen atoms have been substituted by the same or different halogen atoms. The term „cycloalkyf' refers to a saturated mono- or polycyclic hydrocarbon substituent having the indicated number of carbon atoms. Examples of cycloalkyl substituents include -cyclopropyl, -cyclobutyl, - cyclopentyl, -cyclohexyl, -cycloheptyl, -cyclooctyl, -cyclononyl, -cyclodecyl and the like.

The term„alkenyf refers to a saturated, linear or branched non-cyclic hydrocarbon substituent of the indicated number of carbon atoms and containing at least one double carbon -carbon bond. Examples of alkenyl substituents include -vinyl, -allyl, -1 -butenyl, -2-butenyl, -isobutylenyl, -1 -pentenyl, -2-pentenyl, -3- methylo-1 -butenyl, -2-methylo-2-butenyl, -2,3-dimethylo-2-butenyl, -1 -hexenyl, -2-hexenyl, -3-hexenyl, -1 - heptenyl, -2-heptenyl, -3-heptenyl, -1 -octenyl, -2-octenyl, -3-octenyl, -1 -nonenyl, -2-nonenyl, -3-nonenyl, - 1 -decenyl, -2-decenyl, -3-decenyl and the like.

The term„cycloalkenyl" refers to a saturated mono- or polycyclic hydrocarbon substituent of the indicated number of carbon atoms and containing at least one double carbon-carbon bond. Examples of cycloalkenyl substituents include cyclopentenyl, cyclopentadienyl, cyclohexenyl, cyclohexadienyl, cycloheptenyl, cycloheptadienyl, cycloheptatrienyl, cyclooctenyl, cyclooctadienyl, cyclooctatrienyl, cyclooctatetraenyl, cyclononenyl, cyclopentadienyl, cyclodecenyl, cyclodecadienyl and the like.

The term „alkynyf refers to a saturated, linear or branched non-cyclic hydrocarbon substituent of the indicated number of carbon atoms and containing at least one triple carbon-carbon bond. Examples of alkynyl substituents include acetylenyl, propynyl, -1 -butynyl, -2-butynyl, -1 -pentynyl, -2-pentynyl, -3- methyl-1 -butynyl, 4-pentynyl, -1 -hexynyl, 2-hexynyl, -5-hexynyl and the like.

The term„cycloalkynyi' refers to a saturated mono- or polycyclic hydrocarbon substituent of the indicated number of carbon atoms and containing at least one triple carbon-carbon bond. Examples of cycloalkynyl substituents include cyclohexnyl, -cycloheptynyl, -cyclooctynyl and the like.

The term„aryt' refers to an aromatic mono- or polycyclic hydrocarbon substituent having the indicated number of carbon atoms. Examples of aryl substituents include phenyl, -tolyl, -xylyl, -naphthyl, -2,4,6- trimethylphenyl, -2-fluorophenyl, -4-fluorophenyl, -2,4,6-trifluorophenyl, -2,6-difluorophenyl, -4-nitrophenyl and the like.

The term„aralkyt' refers to an alkyl substituent as defined above substituted with at least one aryl as defined above. Examples of aralkyl substituents include benzyl, -diphenylmethyl, -triphenylmethyl and the like.

The term „heteroaryf' refers to an aromatic mono- or polycyclic hydrocarbon substituent having the indicated number of carbon atoms, in which at least one carbon atom is substituted by a heteroatom selected from O, N and S atoms. Examples of heteroaryl substituents include furyl, thienyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridyl, pyrimidyl, triazinyl, indolyl, benzo[b]furyl, benzo[b]thienyl, indazolyl, benzoimidazolyl, azaindolyl, quinolyl, isoquinolyl, carbazolyl and the like.

The term„heterocycle" refers to a saturated or partially non -saturated, mono- or polycyclic hydrocarbon substituent having the indicated number of carbon atoms, in which at least one carbon atom is substituted by a heteroatom selected from O, N and S atoms. Examples of heterocyclic substituents include furyl, thiophenyl, pyrrolyl, oxazolyl, imidazolyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, triazinyl, pyrrolidinonyl, pyrrolidinyl, hydantoinyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydrothiophenyl, quinolinyl, isoquinolinyl, chromonyl, coumarinyl, indolyl, indolizinyl, benzo[b]furanyl, benzo[b]thiophenyl, indazolyl, purinyl, 4/-/-quinolizinyl, isoquinolyl, quinolyl, phthalazinyl, naphthyridinyl, carbazolyl, β- carbolinyl and the like.

The term „neutral ligand" refers to a non-charged substituent capable of coordinating with a metallic centre (the ruthenium atom). Examples of such ligands may include: amines, phosphines and oxides thereof, alkyl and aryl phosphites and phosphates, arsines and oxides thereof, ethers, alkyl and aryl sulphides, coordinated hydrocarbons, alkyl and aryl halides.

The term „anionic ligand" refers to a substituent capable of coordinating with a metallic centre (the ruthenium atom) with a charge capable of partially or completely compensating the charge of the metallic centre. Examples of such ligands may include fluoride, chloride, bromide, iodide, cyanide, cyanate and thiocyanate anions, carboxylic acid anions, alcohol anions, phenolic anions, thiol and thiophenol anions, delocalized charge hydrocarbon anions (e.g. cyclopentadiene), (organo)sulphuric and (organo)phosphoric acid anions and esters thereof (such as, for example, alkylsulphonic and aryl sulphonic acid anions , alkylphosphoric and arylphosphoric acid anions, sulphuric acid alkyl and aryl ester anions, phosphoric acid alkyl and aryl ester anions, alkylphosphoric and arylphosphoric alkyl and aryl ester anions). Optionally, the anionic ligand may have interconnected L , L ² and L ³ groups, such as the catechol anion, the acetylacetone anion, the salicylaldehyde anion. Anionic ligands (X ¹ , X ² ) and neutral ligands (L , L ² , L ³ ) may be interconnected to form multidentate ligands, such as a bidentate ligand (X -X ² ), a tridentate ligand (X -X ² -L ¹ ), a tetradentate ligand (X -X ² -L -L ² ), a bidentate ligand (X -L ¹ ), a tridentate ligand (X -L -L ² ), a tetradentate ligand (X -L -L ² -L ³ ), a bidentate ligand (L -L ² ), a tridentate ligand (L -L ² -L ³ ). Examples of such ligands include catechol anion, acetylacetone anion and salicylaldehyde anion.

The term„heteroatom" refers to an atom selected from the group comprising an atom of oxygen, sulphur, nitrogen, phosphorus and the like.

The term„chlorinated solvent refers to a solvent, the structure of which comprises at least one atom of for example fluorine, chlorine, bromine and iodine; preferably more than one. Examples of such solvents include dichloromethane, chloroform, tetrachloromethane (carbon tetrachloride), 1 ,2-dichloroethane, chlorobenzene, perfluorobenzene, perfluorotoluene, freons and the like.

The term„organic non-polar solvent refers to a solvent characterised by non-existent or very low dipole momentum. Examples of such solvents include pentane, hexane, octane, nonane, decane, benzene, toluene, xylene and the like.

The term„organic polar solvent refers to a solvent characterised by a dipole momentum substantially greater than zero. Examples of such solvents include dimethylformamide (DMF), tetrahydrofuran (THF) and its derivatives, diethyl ether, dichloromethane, ethyl acetate, chloroform, alcohols (MeOH, EtOH or / ^' - PrOH) and the like.

The term„GC" refers to gas chromatography.

The term„HPLC" refers to high performance liquid chromatography, and solvents designated as„HPLC" solvents refer to solvents having sufficient purity for HPLC analysis.

The term„NMR" refers to nuclear magnetic resonance.

The term„NHC" refers to /V-heterocyclic carbene. The term„CAAC" refers to cyclic alkyl amino carbene ligand.

The term„DEDAM" refers to diethyl diallylmalonate.

The term„precatalysf refers to, in relation to ruthenium complexes, a 1 6-electron chemical compound which, after the step of dissociation of one ligand or reorganisation of the molecule, is converted to the 14-electron olefin metathesis catalyst as such, which is active in the catalytic cycle.

Embodiments of the invention

The following examples are provided solely for the purpose of illustrating the invention and for clarifying the individual aspects thereof, and not with the intention to limit it, and should not be considered to be equivalent to the total scope thereof as defined in the appended claims. In the examples below, unless otherwise indicated, standard materials and methods were employed as used in the art or it was proceeded according to the manufacturer's recommendations for particular reagents and methods.

Ethyl undecanoate (EU), 1 -decene, acrylonitrile, methyl acrylate, methyl oleate (MO) and methyl stearate are commercially available compounds. EU and MO were distilled under reduced pressure and stored over activated alumina. 1 -decene, acrylonitrile and methyl acrylate were dried using 4A molecular sieves and deoxygenated under argon. All reactions were conducted under argon. Toluene was washed with citric acid, water, dried using 4A molecular sieves and deoxygenated under argon.

The composition of reaction mixtures was tested by gas chromatography using a PerkinElmer Clarus 680 GC equipped with the GL Sciences InertCap® 5MS/NP capillary column.

The individual components of reaction mixtures were identified by comparing retention times with commercial standards or standards isolated from reaction mixtures for which the structure was confirmed by NMR.

The FID detector response coefficients for the individual ingredients of mixtures were used for calculations (determination method in Example I). The area under the peak of each component in the chromatogram was converted to a percentage in the mixture using the calculated response coefficients.

Example I

CM reaction of methyl acrylate with ethyl undecanoate (S1 )

To the solution of S1 (0.637 g, 3 mmol, 1 eq.), methyl acrylate (1 .08 ml, 12 mmol, 4 eq.) and methyl stearate (internal standard) in toluene (1 1 ml) at 70°C under argon, a solution of precatalyst (0.365 mg, 0.02 mol%, 200 ppm) in toluene (50 μΙ) was added in four portions at 20-minute intervals. The mixture was stirred for 2 hours. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

acry ate ours

Table 1a. Experimental results of the CM reaction of methyl acrylate with S1

precatalyst [Ru] Conversion [%] P1 [%] D1 [%] Selectivity to P1 [%] precatalyst [Ru] Conversion [%] P1 [%] D1 [%] Selectivity to P1 [%]

2be 43 6 36 14

2bc 64 36 26 58

2bf 43 4 37 9

2bd 63 28 33 45

2bh 0 - - -

2bg 0 - - -

2bb 63 12 50 1 9

2ba 61 1 5 44 25

In order to determine the response coefficients of the FID detector for the individual ingredients of reaction mixtures, two aliquots containing a mixture of the S1 substrate, the desired product P1 and the by-product D1 were prepared. The resulting mixtures were diluted with toluene to a volume of 1 0 ml and analysed by gas chromatography. The area under the PP peak for each ingredient (the mean of five injections) was divided by the weight of the ingredient in the aliquot taking into account its purity, to give an absolute response coefficient for the Rf ingredient. Assuming a S1 substrate coefficient of R _f =1 , relative Rf coefficients for the other ingredients were determined. The mean Rf for the two aliquots was determined for calculations.

Table 1 b. Method for determining the response coefficients of the FI D detector for the individual ingredients of a reaction mixture.

Absolute

response Response

Aliquot Area under

Purity coefficient coefficient for

Ingredient weight the peak

per GC [%] Rf=PP/ S1

m [mg] PP [μν ε]

(mx purity) Rf

^Vxs/mg]

Aliquot A:

S1 27.95 98.4 41 1 01 .6 1494.5 1 .00

P1 26.58 98.9 36961 .0 1406.0 0.94

D1 27.57 98.8 45458.4 1 668.9 1 .12

Aliquot B:

S1 27.39 98.4 127135.9 471 7.2 1 .00

P1 28.86 98.9 123728.6 4334.9 0.92

D1 28.1 9 98.8 142693.4 5123.3 1 .09

Mean Rf of the two aliquots :

S1 1.00

P1 0.93

D1 1.10

In further calculations, the area under the peak of each ingredient in the chromatogram was converted to a percentage in the mixture using the calculated response coefficients.

The selectivity of the reaction (S) was determined from the following formula:

(n _P1 + 2 x n _dimer )

where n is the number of moles

The conversion of reaction (C) was determined from the following formula:

where:

PP _S i° and PP _S i is the area under the peak of the substrate at the beginning of the reaction and at its end.

PPis° and PP| _S is the area under the peak of the internal standard (methyl stearate) at the beginning of the reaction and at its end.

Example II

CM reaction of methyl acrylate with S1 in increased temperature

The reaction was carried out according to the procedure described in Example I at 100°C.

Table 2. Experimental results of the CM reaction of methyl acrylate with S1 in increased temp. precatalyst [Ru] Conversion [%] P1 [%] D1 [%] Selectivity to P1 [%]

2bh 7 0.3 5.4 4.5

2bg 12 0.4 7.2 5.1

Example III

CM reaction of acrylonitrile with S1

To the solution of S1 (0.335 g, 1 ,58 mmol, 1 eq.), acrylonitrile (0.207 ml, 3.16 mmol, 2 molar eq.) and methyl stearate (internal standard) in toluene (15.5 ml) at 70°C under argon, , a solution of precatalyst (0.03 mol%, 300 ppm) in toluene (4x50 μΙ) was added in four portions at 5-minute intervals. The mixture was stirred for 2 hours. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

TT 8

O

S1 acrylonitrile

Table 3. Experimental results of the CM reaction of acrylonitrile with S1 precatalyst [Ru] Conversion [%] P2 [%] D1 [%] Selectivity to P2 [%]

2be 46 33 13 71

2bc 86 83 3 97

2bf 49 29 20 59

2bd 87 84 3 96

2bb 43 22 21 51

2ba 69 60 9 87 Example IV

CM reaction of acrylonitrile with S1 in increased temperature

The reaction was carried out according to the procedure described in Example III at 100°C.

Q. ⁸ Toluene,

_S acrylonitrile 0,1 M 100°C, _{p2 m}

2 hours

Table 4. Experimental results of the CM reaction of acrylonitrile with S1 in increased temp.

Precatalyst [Ru] Conversion [%] P1 [%] D1 [%] Selectivity to P2 [%]

2bh 21 7 14 33

2bg 25 13 12 51

Example V

CM reaction of acrylonitrile with S1 - effect of the S1 concentration

To the solution of S1 (0.335 g, 1 .58 mmol, 1 molar eq.), acrylonitrile (0.207 ml, 3,16 mmol, 2 molar eq.) and methyl stearate (internal standard) in the appropriate volume of toluene at 70°C under argon, , a solution of precatalyst (0.03 mol%, 300 ppm) in toluene (50 μΙ) was added in one portion. The mixture was stirred for 2 hours. The sample was analysed by gas chromatography.

_ΟΛ 70°C, 2 hours _ηΛ

S1 acrylonitrile P2 D1

Table 5. Experimental results of the CM reaction of acrylonitrile with S1 in various concentrations.

C°si [M] Conversion [%] P2 [%] D1 [%] Selectivity to P2 [%]

0.1 86 83 3 97

0.25 95 92 3 97

1 87 82 5 94

Example VI

CM reaction of acrylonitrile with S1 - effect of the acrylonitrile volume

To the solution of S1 (0.335 g, 1 .58 mmol, 1 molar eq.), acrylonitrile (1 ,1 or 2 or 4 molar eq.) and methyl stearate (internal standard) in (C° _S i 0.25 M) at 70°C under argon, a solution of precatalyst (0.0075 mol%, 75 ppm) in toluene (50 μΙ) was added in one portion. The mixture was stirred for 2 hours. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

acrylonitrile

Table 6. Experimental results of the CM reaction of acrylonitrile with S1 - varying volume of acrylonitrile. acrylonitrile [eq.] Conversion [%] P2 [%] D1 [%] Selectivity to P2 [%] TON

1 .1 87 81 6 93 10800

2 84 80 4 95 10667

4 75 72 3 97 9600

Example VII

CM reaction of acrylonitrile with S1 - effect of the S1 concentration Comparison of the complexes of the invention with the standard nG complex.

To a solution of S1 (1 .606 g, 7.56 mmol, 1 molar eq.), acrylonitrile (0.991 ml, 15.13 mmol, 2 molar eq.) and methyl stearate (internal standard) in toluene (C° _S i 0.1 or 0.25 M) at 70°C under argon a solution of the precatalyst in toluene was added. For reactions catalysed with 0.015 mol% of the ruthenium complex, the precatalyst solution was added in four portions at 5-minute intervals. For reactions catalysed with 0.0075 mol% of the ruthenium complex, the precatalyst solution was added dropwise over 1 h using a syringe. For the reaction catalysed with 0.0025 mol% of the ruthenium complex, the precatalyst solution was added dropwise over 1 h using a syringe pump. The total reaction time was in each case 2h. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

Table 7. Ex erimental results of the CM reaction of acrylonitrile with S1 - comparison of variables

2bc, 0.015 0.25 93 90 3 97.1 6000

2bc, 0.0075 0.1 82 78 4 95.4 10400

2bc, 0.0075 0.25 84 80 4 95.3 10667 nG, 0.0075 0.25 27 26 1 96.1 3467

2ad, 0.0075 0.25 86 81 5 93.9 10800

2af, 0.0075 0.25 46 21 25 45.0 2800

2bc, 0.0025 ^a 0.25 48 43 5 89.9 17200

The reaction mixture was gently blown with argon to actively remove released ethylene

Example VIII

CM reaction of acrylonitrile with S1 - effect of the catalyst type and volume & manner of adding acrylonitrile To a solution of S1 (1 .606 g, 7.56 mmol, 1 molar eq.), acrylonitrile (0.495 ml, 1 molar eq.) and methyl stearate (internal standard) in toluene (23.8 ml) at 70°C under argon, the precatalyst solution (0.0025 mol%, 25 ppm) in toluene (3 ml) and acrylonitrile solution (1 molar eq.) in toluene (3 ml solution volume) were added dropwise using a syringe pump over 1 hour. The reaction mixture was gently blown with argon to actively remove released ethylene. The total reaction time was in each case 2h. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography. 2 hours

S1 acrylonitrile P2 D1

Table 8. Experimental results of the CM reaction of acrylonitrile with S1 precatalyst [Ru] Conversion [%] P2 [%] D1 [%] Selectivity to P2 [%] TON

2bc 63 56 7 89 22400

2bd 73 62 1 1 84 24800

Example IX

CM reaction of acrylonitrile with S1 - effect of the temperature

To a solution of S1 (1 .606 g, 7.56 mmol, 1 molar eq.), acrylonitrile (0.495 ml, 7.56 mmol, 1 molar eq.) and methyl stearate (internal standard) in toluene (C° _S i 0.25 M) under argon, the precatalyst solution in toluene (1 ml) and acrylonitrile (1 molar eq.) were added dropwise over 1 h. The reaction mixture, in which 0.002 mol% of the precatalyst was used, was gently blown with argon to actively remove ethylene. The total reaction time was in each case 2h. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

Table 9. Results of CM of acrylonitrile with S1 in various temperatures.

precatalyst [Ru] Temp. Conversion P2 D1 Select. To TON

(mol%) [°C] \%] \%] \%] P2 [%1

2bd, 0.005 70 69 60 9 87 12000

2bd, 0.005 85 79 69 10 88 13800

2bd, 0.005 100 3 2 1 60 400

2bd, 0.002 85 71 57 14 80 28500

Example X

CM reaction of methyl acrylate with ethyl undecanoate (S1 )

To a solution of S2 (1 .506 g, 5.08 mmol, 1 molar eq.) and acrylonitrile (0.666 ml, 10.16 mmol, 2 molar eq.) in toluene (12 ml, C° _S i 0.4 M), the precatalyst solution (0.0125 mol, 125 ppm) in toluene (6 ml) and acrylonitrile solution (2.5 molar eq.) in toluene (6 ml) were added dropwise over 2.5 hours. The reaction mixture was gently blown with argon to actively remove released ethylene. After 3.5 hours from the beginning of the reaction, a sample was taken, to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

expected product byproduct

expected product

Table 10. Experimental results of the CM reaction of acrylonitrile with S2

precatalyst P3[%] selectivity

P4[%] (E/Z) P5+P6[%] D2+D3[%] S2[%]

[Ru], %mol (E/Z) to P3+P4[%]

2bc, 0.01 35 (1 /2) 34 (1 /2) 16 2 13 79

2bc, 0.0125 37 (1 /2) 37 (1 /2) 14 2 9 82

nG 0.01 19 (1 /3) 19 (1 /3) 19 9 35 58

nG, 0.0125 21 (1 /3) 21 (1 /3) 20 9 30 59

Example XI

CM reaction of 1 -decene (P6) with acrylonitrile

To a solution of 1 -decene (2.109 g, 15.04 mmol), acrylonitrile (0.985 ml, 15.04 mmol, 1 molar eq.) and methyl stearate (internal standard) in toluene (29 ml, C decene 0.5 M) at 70°C, a solution of the 2bdcomplex (0.0075 mol%, 75 ppm) in toluene (1 ml) using a syringe and (using a second syringe) acrylonitrile (1 molar eq.) were added over 1 hour. The mixture was stirred for one more hour at the same temperature. A sample was taken to which 3 drops of ethyl vinyl ether were added to deactivate the catalyst. The sample was analysed by gas chromatography.

P6 2 hours P4 D3

Table 11. Experimental results of the CM reaction of acrylonitrile with P6

Conversion [%] P4 [%] (E/Z) D3 [%] Selectivity to P4 [%] TON

91 84 (1 /4) 7 92 1 1200

Example XII RCM reaction of diethyl diallylmalonate (S3)

To a solution of S3 (0.240 g, 1 .0 mmol) in toluene (10 ml) at 29°C, the precatalyst solution (0.1 mol%) in toluene (50 μΙ) was added in one portion. At required intervals, samples were taken of the reaction mixture to which a few drops of ethyl vinyl ether were added to deactivate the catalyst. The samples were analysed by gas chromatography.

S3 P7

Table 12. Experimental results of the CM reaction of methyl acrylate with S1

Conversion [%]

Time [min]

2bc 2be 2bd 2bf 2af 2bg 2bh 2ba 2bb 2ab 2cb

2.5 90 20 96 - - - - 80 - - -

5 99 48 99 10 6 0.5 1 98 9 6 13

10 100 77 100 32 19 0.9 1 99 31 16 39

20 - 92 - 63 43 1 .8 1 100 71 39 77

30 - 95 - 76 63 3 - - 86 54 91

45 - 97 - 85 77 5 4 - 93 68 97

60 - 98 - 90 84 10 6 - 95 77 97

Example XIII

Homometathesis reaction of the S1 substrate to D1

A mixture of S1 (3.0 g, 14.13 mmol) with methyl stearate (internal standard) was placed under argon in a round bottom flask. After heating the mixture to 60°C, a solution of precatalyst in toluene was added at 15-minute intervals (2+2+1 +1 +1 +1 ppm, total of 8 ppm). The mixture was stirred for 2 hours. Samples were taken to which a few drops of ethyl vinyl ether were added to deactivate the catalyst. The samples were analysed by gas chromatography.

Table 13. Experimental results of the homodimerization reaction of S1 precatalyst [Ru] Conversion [%] D1 [%] Selectivity to D1 [%] TON

2bd 75 67 89 41875

2bf 82 77 94 48125 nG-diEt 48 42 88 26250

Example XIV

Reaction for preparing complex 2bc

precursor ligand

b

To CAAC c precursor (2,10 g, 5.34 mmol, 2 molar eq.) dry deoxygenated toluene (48 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.34 ml, 5.34 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.37 g, 2.67 mmol, 1 molar eq.) was added. After 2 minutes the mixture was cooled to 60°C. Benzylidene ligand b was added (0.709 g, 3.20 mmol, 1 .2 molar eq.) and CuCI (0.925 g, 9.35 mmol, 3.5 molar eq.). The mixture was stirred for 5 minutes at 60°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2bc precatalyst (0.455 g, 25%). Mixture of A:B isomers = 2.2:1

Due to the very complex ¹ H NMR spectrum, only the chemical shifts of the characteristic benzylidene protons are indicated: A isomer: singlet 17.73 ppm; B isomer: singlet 16.16 ppm (C ₆ D ₆ ).

HRMS: ESI was calculated for C ₃₂ H ₃₈ N ₂ 0 ₃ NaCl ₂ Ru [M+Na] ⁺ : 693.1201 ; found: 693.1 1 79.

Elemental analysis: calculated for C ₃ 2H3 ₈ N ₂ Cl ₂ 0 ₃ Ru:

C 57.31 ; H 5.71 ; N 4.18; CI 10.57; found: C 57.43; H 5.72; N 4.14; CI 1 0.42:

Example XV

Reaction for preparing complex 2be

M10 precursor ligand b 2be

To CAAC e precursor (1 .66 g, 5.0 mmol, 2 molar eq.) dry deoxygenated toluene (20 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.0 ml, 5.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.22 g, 2.5 mmol, 1 molar eq.) was added. After 2 minutes benzylidene ligand b (0.664 g, 3.0 mmol, 1 .2 molar eq.) and CuCI (0.866 g, 8.75 mmol, 3.5 molar eq.) were added. The mixture was stirred for 30 minutes at 80°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was dissolved in methylene chloride and excess isopropanol was added. The methylene chloride was slowly removed under reduced pressure - the resulting crystals were filtered off and washed in a minimum volume of isopropanol. This was dried under highly reduced pressure to give a green crystalline solid - the 2be precatalyst (0.215 g, 14%).

¹ H NMR (CD ₂ Ck 500 MHz): δ = 16.12 (s, 1 H), 8.48 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.75 (d, J = 2.8 Hz, 1 H), 7.20 (s, 2H), 7.08 (d, J = 9.1 Hz, 1 H), 5.25 (septet, J = 6.1 Hz, 1 H), 2.54 (s, 3H), 2.21 (s, 2H), 2.19 (s, 6H), 2.05 (s, 6H), 1 .74 (d, J = 6.2 Hz, 6H), 1 .43 (s, 6H).

¹³ C NMR (CD Ck 125 MHz) : δ = 292.6, 264.1 , 156.7, 144.2, 143.3, 139.7, 138.5, 137.9, 131 .2, 125.7, 1 18.6, 1 13.7, 79.6, 78.1 , 56.5, 52.4, 29.7, 29.3, 22.3, 21 .2, 20.9.

HRMS-ESI was calculated for C ₂₇ H3 ₆ N ₂ 0 ₃ NaCI ₂ Ru [M+Na] ⁺ : 631 .1044; found: 631 .1028.

Elemental analysis: calculated for C ₂ 7H3 ₆ N ₂ Cl ₂ 0 ₃ Ru:

C 53.29; H 5.96; N 4.60; CI 1 1 .65; found: C 53.21 ; H 5.93; N 4.53; CI 1 1 .61 :

Example XVI

Reaction for preparing complex 2bd

To CAAC d precursor (2,44 g, 6.0 mmol, 2 molar eq.) dry deoxygenated toluene (24 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 6.0 ml, 6.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.66 g, 3.0 mmol, 1 molar eq.) was added. After 2 minutes, benzylidene ligand b (1 .33 g, 6.0 mmol, 2.0 molar eq.) was added. The mixture was stirred for 30 minutes at 105°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was washed with a mixture of ethyl acetate-cyclohexane 5:95, and then dissolved in methylene chloride and excess isopropanol was added. The methylene chloride was slowly removed under reduced pressure - the resulting crystals were filtered off and washed in a minimum volume of isopropanol. This was dried under highly reduced pressure to give a green crystalline solid - the 2bd precatalyst (0.495 g, 24%).

¹ H NMR (CgDg. 500 MHz): δ = [17.73 (s), 16.37 (s), 1 H], 8.27 (br. s, 1 H), 7.89 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.78 (br. s, 1 H), 7.48 (br. s, 1 H), 7.36-7.16 (m, 6H), 6.03 (d, J = 9.1 Hz, 1 H), 4.43-4.33 (m, 1 H), 2.95-1 .80 (m, 8H), 1 .50-0.60 (m, 19H).

¹³ C NMR (CKDK. 125 MHz) : δ = 292.2, 262.4, 157.0, 144.0, 143.4, 139.1 , 130.0, 129.7, 127.9, 127.6, 125.5, 1 18.2, 1 13.4, 78.4, 77.3, 63.7, 49.2, 31 .1 , 27.9, 27.6, 26.3, 25.9, 24.9, 22.5, 15.5, 14.9.

HRMS: ESI was calculated for C ₃ 3H4oN ₂ 0 ₃ CIRu [M-CI] ⁺ : 649.1771 ; found: 649.1746.

Elemental analysis: calculated for C33H40N2CI2O3RU :

C 57.89; H 5.89; N 4.09; CI 10.36; found: C 57.98; H 5.99; N 4.08; CI 1 0.44: Example XVII

Reaction for preparing complex 2bf

To CAAC f precursor (3,45 g, 10.0 mmol, 2 molar eq.) dry deoxygenated toluene (40 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 10.0 ml, 10.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (4.43 g, 5.0 mmol, 1 molar eq.) was added. After 2 minutes the mixture was cooled to 60°C. Benzylidene ligand b (1 .33 g, 6.0 mmol, 1 .2 molar eq.) and CuCI (1 .73 g, 17.5 mmol, 3.5 molar eq.) were added. The mixture was stirred for 5 minutes at 60°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2bf precatalyst (1 .57 g, 50%).

¹ H NMR (CD Ck 500 MHz): δ = 16.29 (s, 1 H), 8.46 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.72 (d, J = 2.8 Hz, 1 H), 7.20 (s, 2H), 7.08 (d, J = 8.7 Hz, 1 H), 5.26 (septet, J = 6.1 Hz, 1 H), 2.61 (s, 3H), -2.49 (s, 2H), 2.21 (s, 6H), 2.07 (s, 6H), 1 .77 (d, J = 6.2 Hz, 6H), 1 .33 (s, 6H).

¹³ C NMR (CD ₂ Ck 125 MHz) : δ = 290.4, 263.8, 165.6, 157.1 , 143.7, 143.4, 138.8, 129.9, 127.7, 125.7, 1 18.3, 1 13.7, 79.4, 78.2, 56.5, 52.3, 29.9, 28.9, 25.3, 22.4, 14.9.

HRMS: ESI was calculated for C ₂₈ H ₃₉ N ₂ 0 ₃ Ru [M-2CI+H] ⁺ : 553.2006; found: 553.2004.

Elemental analysis: calculated for C28H38N2CI2O3RU :

C 54.02; H 6.1 5; N 4.50; CI 1 1 .39; found: C 54.18; H 6.09; N 4.42; CI 1 1 .20:

Example XVIII

Reaction for preparing complex 2ad

To CAAC d precursor (0,407 g, 1 .0 mmol, 2 molar eq.) dry deoxygenated toluene (4 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 1 .0 ml, 1 .0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (0.443 g, 0.5 mmol, 1 molar eq.) was added. After 2 minutes, benzylidene ligand b (0.176 g, 1 .0 mmol, 2.0 molar eq.) was added. The mixture was stirred for 30 minutes at 105°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in methylene chloride and excess isopropanol was added. The methylene chloride was slowly removed under reduced pressure - the resulting crystals were filtered off and washed in a minimum volume of isopropanol. This was dried under highly reduced pressure to give a green crystalline solid - the 2ad precatalyst (0.151 g, 47%). Mixture of A:B isomers = 1 :3

¹ H NMR (CKDK. 500 MHz): δ = [17.89 (s, 0,25H, A isomer), 16.52 (s, 0.75H, B isomer), 1 H], 8.55-7.70 (m, 2H), 7.60-7.18 (m, 6H), 7.12-7.07 (m, 1 H), 6.98-6.84 (m, 1 H), 6.68-6.43 (m, 1 H), 6.38 (d, J = 8.3 Hz, 1 H), 4.60-4.45 (m, 1 H), 3.10-2.00 (m, 8H), 2.00-1 .14 (m, 9H), 1 .07 (s, 5H), 0.99 (s, 3H), 0.85 (br. s, 2H).

¹³ C NMR (CgDg. 125 MHz) : δ = 296.9, 296.6, 265.0, 153.4, 150.9, 146.3, 144.9, 144.5, 144.3, 143.7, 139.7, 130.9, 130.1 , 129.7, 129.5, 128.0, 127.7, 127.3, 124.0, 122.2, 1 13.8, 78.0, 75.8, 75.1 , 64.2, 63.8, 58.3, 49.3, 31 .2, 30.3, 29.8, 28.1 , 27.5, 26.4, 25.9, 25.0, 22.7, 22.6, 16.3, 1 5.7, 1 5.0.

HRMS: ESI was calculated for C ₃₃ H ₄ i NCIORu [M-CI] ⁺ : 604.1920; found: 604.1 917.

Elemental analysis: calculated for C3 ₃ H ₄₁ NCl ₂ 0Ru :

C 61 .96; H 6.46; N 2.19; CI 1 1 .08; found: C 61 .93; H 6.59; N 2.14; CI 1 1 .23:

Example XIX

Reaction for preparing complex 2af

To CAAC f precursor (1 ,73 g, 5.0 mmol, 2 molar eq.) dry deoxygenated toluene (20 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.0 ml, 5.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.22 g, 2.5 mmol, 1 molar eq.) was added. After 2 minutes the mixture was cooled to 60°C. Benzylidene ligand a (0.529 g, 3.0 mmol, 1 .2 molar eq.) and CuCI (0.866 g, 8.75 mmol, 3.5 molar eq.) were added. The mixture was stirred for 5 minutes at 60 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2af precatalyst (0.584 g, 40%).

¹ H NMR (C«D«. 500 MHz): δ = 16.41 (s, 1 H), 7.33 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.01 (d, J = 1 .6 Hz, 1 H), 6.64 (s, 2H), 7.08 (d, J = 9.1 Hz, 1 H), 4.67 (septet, J = 6.1 Hz, 1 H), 2.87 (s, 3H), 2.45 (s, 2H), 2.23 (s, 6H), 1 .77 (s, 6H), 1 .70 (d, J = 6.1 Hz, 6H), 0.97 (s, 6H).

Example XX Reaction for preparing complex 2bq

precursor

To CAAC g precursor (0.348 g, 0.8 mmol, 2 molar eq.) dry deoxygenated toluene (3.2 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 0.8 ml, 0.8 mmol, 2 molar eq.) was added. After 1 minute, a solid Nitro-I complex (0.258 g, 0.4 mmol, 1 molar eq.) was added. The mixture was stirred for 15 minutes at 80°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was dissolved in methylene chloride and excess isopropanol was added. Methylene chloride was dried under vacuum - the crystals obtained were washed with a minimal volume of isopropanol, and then dried under highly reduced pressure to give a green crystalline solid - the 2bg precatalyst (0.037 g, 13%).

¹ H NMR (CD ₂ Ck 500 MHz) : δ = 16.49 (s, 1 H), 8.40 (dd, J = 9,1 ; 2.7 Hz, 1 H), 8.24-8.20 (m, 2H), 7.74 (t, J = 7.8 Hz, 1 H), 7.59-7.49 (m 5H), 7.40-7.35 (m, 1 H), 7.00 (d, J = 9.1 Hz, 1 H), 5.05 (septet, J = 6.1 Hz, 1 H), 3.15 (d, J = 12.9 Hz, 1 H), 3.04 (septet, J = 6.6 Hz, 1 H), 2.93 (septet, J = 6.5 Hz, 1 H), 2.38 (d, J = 12.8 Hz, 1 H), 2.33 (s, 3H), 1 .57 (d, J = 6.1 Hz, 3H), 1 .53 (s, 3H), 1 .43-1 .40 (m, 6H), 1 .36 (d, J = 6.6 Hz, 3H), 1 .27 (d, J = 6.6 Hz, 3H), 0.80 (d, J = 6.5 Hz, 3H), 0.48 (d, J = 6.4 Hz, 3H).

¹³ C NMR (CD Ck 125 MHz) : δ = 291 .8, 291 .4, 262.2, 157.4, 148.8, 148.5, 143.2 (2C), 142.9, 137.0, 130.5, 129.8, 129.6, 128.0, 126.8, 126.6, 125.9, 1 18.6, 1 13.9, 78.7, 77.9, 63.6, 48.6, 33.0, 29.4, 29.0, 28.8, 28.1 , 27.5, 26.5, 24.7, 24.6, 22.7, 22.6.

HRMS: ESI was calculated for C ₃₅ H ₄₄ N ₂ 0 ₃ NaCl ₂ Ru [M+Na] ⁺ : 735.1670; found: 735.1639.

Elemental analysis: calculated for C6H12N2CI203Ru:

C 60.47; H 6.68; N 3.71 ; CI 9.39; found: C 60.20; H 6.52; N 3.77; CI 9.48:

Example XXI

Reaction for preparing complex 2bh

To CAAC h precursor (1 ,87 g, 5.0 mmol, 2 molar eq.) dry deoxygenated toluene (20 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.0 ml, 5.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.22 g, 2.5 mmol, 1 molar eq.) was added. After 2 minutes benzylidene ligand b (0.664 g, 3.0 mmol, 1 .2 molar eq.) and CuCI (0.866 g, 8.75 mmol, 3.5 molar eq.) were added. The mixture was stirred for 15 minutes at 80 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was dissolved in methylene chloride and excess isopropanol was added. Methylene chloride was dried under vacuum - the crystals obtained were washed with a minimal volume of isopropanol, and then dried under highly reduced pressure to give a green crystalline solid - the 2bh precatalyst (0.490 g, 30%).

¹ H NMR (CD?Ck 500 MHz): δ = 16.31 (s, 1 H), 8.42 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.73 (d, J = 2.7 Hz, 1 H), 7.52 (s, 2H), 7.09 (d, J = 9.1 Hz, 1 H), 5.27 (septet, J = 6.2 Hz, 1 H), 2.96 (s, 3H), 2.20 (s, 2H), 2.09 (s, 6H), 1 .79 (s, 6H), 1 .28 (d, J = 6.7 Hz, 6H), 0.66 (s, 6H).

¹³ C NMR (CD?Ck 125 MHz) : δ = 288.0, 287.7, 264.8, 157.5, 148.7, 143.3, 142.7, (2C), 136.7, 130.4, 126.5, 125.7, 1 18.3, 1 13.8, 79.1 , 78.3, 56.7, 51 .9, 30.2, 29.5, 29.0, 27.8, 25.7, 24.6, 22.4.

HRMS: ESI was calculated for C30H42N2O3CIRU [M-CI] ⁺ : 615.1927; found: 615.1918.

Elemental analysis: calculated for C30H42N2CI2O3RU :

C 55.38; H 6.51 ; N 4.31 ; CI 10.90; found: C 55.15; H 6.45; N 4.15; CI 10.86:

Example XXII

Reaction for preparing complex 2ba

precursor ligand b

To CAAC a precursor (0.81 5 g, 2.0 mmol, 2 molar eq.) dry deoxygenated toluene (8 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 2.0 ml, 2.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (0.887 g, 1 .0 mmol, 1 molar eq.) was added. After 2 minutes benzylidene ligand b (0.266 g, 1 .2 mmol, 1 .2 molar eq.) and CuCI (0.346 g, 3.50 mmol, 3.5 molar eq.) were added. The mixture was stirred for 15 minutes at 80 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with ethyl acetate-cyclohexane mixture 5:95. This was dissolved in methylene chloride and excess methanol was added. Methylene chloride was dried under vacuum - the crystals obtained were washed with a minimal volume of methanol, and then dried under highly reduced pressure to give a green crystalline solid - the 2ba precatalyst (0.235 g, 34%).

Mixture of isomers. ¹ H NMR (C«D«.500 MHz): δ = [16.29 (br. s), 16.25 (s), 1 H], 8.35-8.15 (m, 2H), 7.87 (dd, J = 9.1 ; 2.8 Hz, 1H), 7.77 (dd, J= 19.6; 2.7 Hz, 1H), 7.52 (t, J= 7.9 Hz, 1H), 7.45 (t, J= 7.6 Hz, 1H), 7.35-7.20 (m, 2H), 7.08-6.88 (m, 2H), 5.98 (d, J=9.1 Hz, 1H), 4.35 (ddt, J= 15.9; 12.3; 6.1 Hz, 1H), 3.09 (septet, J= 6.9 Hz, 1H), 2.88-2.67 (m, 1H), 2.52-2.28 (m, 5H), 2.22 (s, 2H), 1.93-1.86 (m, 1H), 1.48-1.33 (m, 3H), 1.32-1.20 (m, 4H), 1.19-0.97 (m, 10H).

¹³ C NMR (CgDg. 125 MHz): δ = 292.6, 291.6, 262.9, 157.0, 149.5, 149.3, 144.0, 143.6, 143.3, 142.3, 138.9, 138.8 (2C), 138.6, 132.8, 132.7, 132.0, 130.7, 130.5 (2C), 130.1 (2C), 129.9, 129.6 (2C), 129.3, 129.0, 128.9, 128.0, 127.9, 126.9, 126.4, 125.7, 125.5, 118.6, 118.4, 113.5, 78.4, 78.3, 77.4, 77.3, 64.2, 64.0, 63.5, 49.9, 49.1, 31.8, 31.4, 29.3, 28.8, 28.6, 28.4, 27.5, 27.4, 27.3, 26.2, 25.9, 24.5, 23.1, 22.5, 22.3, 21.9.

LRMS: ESI was calculated for C ₃ 3H4oN ₂ 0 ₃ CIRu [M-CI] ⁺ : 649.18; found: 649.18.

Elemental analysis: calculated for solvate with 0.5 of isopropanol particle [M+0.5C ₃ H ₈ 0] C ₃ H ₈ N2CI ₂ 0 ₃ .5Ru: C 57.98; H 6.21 ; N 3.92; CI 9.92; found: C 58.08; H 6.04; N 3.89; CI 10.12:

Example XXIII

Reaction for preparing complex 2bb

To CAAC b precursor (1.73g, 5.0 mmol, 2 molar eq.) dry deoxygenated toluene (20 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.0 ml, 5.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.22 g, 2.5 mmol, 1 molar eq.) was added. After 2 minutes the mixture was cooled to 60 °C. Benzylidene ligand b (0.664 g, 3.0 mmol, 1.2 molar eq.) and CuCI (0.866g, 8.75 mmol, 3.5 molar eq.) were added. The mixture was stirred for 5 minutes at 60 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2bb precatalyst (0.663 g, 42%).

¹ H NMR (CD Ck 500 MHz): δ = 16.19 (s, 1 H), 8.45 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.70 (d, J = 2.7 Hz, 1 H), 7.65 (t, J= 7.7 Hz, 1H), 7.55 (dd, J= 8.0; 1.5 Hz, 1H), 7.35 (ddd, J= 7.5; 1.6; 0.7 Hz, 1H), 7.08 (d, J= 8.9 Hz, 1H), 5.26 (sept, J= 6.2 Hz, 1H), 2.97 (sept, J = 6.7 Hz, 1H), 2.26-2.19 (m, 5H), 2.13 (s, 3H), 2.03 (s, 3H), 1.77 (dd, J = 16.1 ; 6.1 Hz, 6H), 1.43 (s, 3H), 1.38 (s, 3H), 1.30 (d, J = 6.6 Hz, 3H), 0.68 (d, J = 6.5 Hz, 3H).

¹³ C NMR (CD ₂ Ck 125 MHz): δ = 290,2, 264.6, 157.2, 149.1, 143.5, 143.4, 138.5, 138.4, 130.4, 130.0, 126.5, 125.8, 118.4, 113.7, 79.4, 78.2, 56.6, 52.3, 29.9, 29.7, 29.6, 29.1, 28.9, 26.3, 24.3, 22.4, 22.3, 21.8. HRMS: ESI was calculated for C ₂₈ H ₃₈ CIN ₂ 0 ₃ Ru [M-CI] ⁺ : 587.1613; found: 587.1636.

Elemental analysis: calculated for C ₂ 8H3 ₈ N2Cl20 ₃ Ru:

C 54.02; H 6.1 5; N 4.50; CI 1 1 .39; found: C 54.1 9; H 6.1 8; N 4.37; CI 1 1 .21 :

Example XXIV

Reaction for preparing complex 2ab

To CAAC b precursor (1 .73 g, 5.0 mmol, 2 molar eq.) dry deoxygenated toluene (20 ml) was added under argon. The mixture was heated to 80°C and a solution of LiHMDS in toluene (1 M, 5.0 ml, 5.0 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.22 g, 2.5 mmol, 1 molar eq.) was added. After 2 minutes the mixture was cooled to 60°C. Benzylidene ligand a (0.529 g, 3.0 mmol, 1 .2 molar eq.) and CuCI (0.866 g, 8.75 mmol, 3.5 molar eq.) were added. The mixture was stirred for 5 minutes at 60°C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2ab precatalyst (0.688 g, 47%).

¹ H NMR (CD ₂ Ck 500 MHz): δ = 16.20 (s, 1 H), 7.60-7.53 (m, 2H), 7.50-7.47 (m, 1 H), 7.29 (ddd, J = 7.4; 1 .7; 0.8 Hz, 1 H), 6.97 (d, J = 8.3 Hz, 1 H), 6.92-6.85 (m, 2H), 5.16 (sept, J = 6.1 Hz, 1 H), 2.98 (sept, J = 6.6 Hz, 1 H), 2.24 (s, 3H), 2.23-2.16 (m, 2H), 2.13 (s, 3H), 2.02 (s, 3H), 1 .75 (d, J= 6.1 Hz, 3H), 1 .71 (d, J = 6.1 Hz, 3H), 1 .40 (s, 3H), 1 .36 (s, 3H), 1 .28 (d, J = 6.7 Hz, 3H), 0.67 (d, J = 6.5 Hz, 3H).

Example XXV

Reaction for preparing complex 2cb

To CAAC b precursor (1 ,56 g, 4.51 mmol, 2 molar eq.) dry deoxygenated toluene (18 ml) was added under argon. The mixture was heated to 60 °C and a solution of LiHMDS in toluene (1 M, 4.51 ml, 4.51 mmol, 2 molar eq.) was added. After 1 minute, a solid M10 complex (2.00 g, 2.26 mmol, 1 molar eq.) was added. After 2 minutes benzylidene ligand c (0.558 g, 2.71 mmol, 1 .2 molar eq.) and CuCI (0.781 g, 7.89 mmol, 3.5 molar eq.) was added. The mixture was stirred for 5 minutes at 60 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: toluene). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was washed with isopropanol and dried under highly reduced pressure to give a green crystalline solid - the 2cb precatalyst (0.741 g, 54%).

¹ H NMR (CKDR. 500 MHz) : δ = 16.24 (s, 1 H), 7.21 -7.17 (m, 2H), 7.00-6.95 (m, 1 H), 6.83 (dd, J = 8.9; 3.0 Hz, 1 H), 6.65 (d, J = 3.0 Hz, 1 H), 6.38 (dd, J = 9.6; 1 .0 Hz, 1 H), 4.67 (septet, J = 6.1 Hz, 1 H), 3.35 (s, 1 H), 3.14 (septet, J = 6.6 Hz, 1 H), 2.28 (d, J = 3.6 Hz, 6H), 2.20 (s, 3H), 1 .83-1 .71 (m, 8H), 1 .13 (d, J = 6.7 Hz, 3H), 1 .03 (s, 3H), 0.94 (s, 3H), 0.91 (d, J = 6.5 Hz, 3H).

¹³ C NMR (CD ₂ Ck 125 MHz): δ = 292.3, 268.5, 155.5, 149.7, 147.7, 144.8, 139.2, 139.1 , 130.1 , 129.4, 128.9, 127.9, 126.3, 1 15.5, 1 13.8, 109.0, 78.1 , 75.2, 56.8, 55.9, 52.1 , 29.9, 29.8, 29.7, 29.0, 28.8, 26.9, 25.9, 24.5, 22.5 (2C), 22.1 .

HRMS: ESI was calculated for C29H41 NO3CIRU [M-CI] ⁺ : 572.1869; found: 572.1 870.

Elemental analysis: calculated for C29H ₄₁ NCl ₂ 0 ₃ Ru:

C 57.32; H 6.80; N 2.31 ; CI 1 1 .67; found: C 57.1 0; H 6.71 ; N 2.36; CI 1 1 .62:

Example XXVI

Reaction for preparing complex nG-diEt

To NHC diEt precursor (5.00 g, 1 1 .84 mmol, 1 .18 molar eq.) dry deoxygenated toluene (93 ml) was added under argon. The mixture was heated to 80°C and a solution of potassium ferf-amylate in toluene (1 .7 M, 5.0 ml, 5.0 mmol, 1 .15 molar eq.) was added. After 10 minutes, a solid M10 complex (8.90 g, 10.03 mmol, 1 molar eq.) was added. After 10 minutes the mixture was cooled to 50°C. Benzylidene ligand b (2.66 g, 12.04 mmol, 1 .2 molar eq.) and CuCI (2.48 g, 25.08 mmol, 2.5 molar eq.) were added. The mixture was stirred for 20 minutes at 50 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (eluent: ethyl acetate - cyclohexane 1 :9). The green fraction was collected and concentrated to dryness. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated, and the residue was dissolved in methylene chloride and excess methanol was added. The methylene chloride was slowly removed under reduced pressure - the resulting crystals were filtered off and washed in a minimum volume of methanol. This was dried under highly reduced pressure to give a green crystalline solid - the nG-diEt precatalyst (2.20 g, 31 %).

¹ H NMR (CDgCk 500 MHz): δ = 16.32 (s, 1 H), 8.41 (dd, J = 9.1 ; 2.7 Hz, 1 H), 7.76 (d, J = 2.8 Hz, 1 H), 7.58-7.50 (m, 2H), 7.38-7.32 (m, 4H), 6.92 (d, J = 9.1 Hz, 1 H), 4.96 (septet, J = 6.1 Hz, 1 H), 4.22 (s, 4H), 3.05-2.90 (br. s, 4H), 2.84 (dq, J = 15.1 ; 7.5 Hz, 4H), 1 .28-1 .22 (m, 18H). C NMR (CD Ck 125 MHz): δ = 287.0, 209.0, 161 .0, 157.0, 145.3, 144.9, 143.7, 141 .6, 137.5, 132.5, 132.4 (2C), 130.1 , 129.9, 129.1 , 129.0, 128.2, 127.3, 127.1 , 126.8, 125.6, 125.1 , 124.7, 123.4, 1 17.1 , 1 13.4, 1 13.0, 78.4, 72.4, 25.5, 22.3, 21 .6, 15.2.

HRMS: ESI was calculated for C33H41 N3O3CIRU [M-CI] ⁺ : 664.1880; found: 664.1876.

Elemental analysis: calculated for CssH^ NsC^OsRu:

C 56.65; H 5.91 ; N 6.01 ; CI 10.13; found: C 56.47; H 5.76; N 5.84; CI 1 0.04:

Example XXVII

Reaction for preparing complex 2ad

To complex 3 (2.00 g, 2.0 mmol, 1 molar eq.) dry deoxygenated toluene (20 ml) and benzylidene ligand d (0.568 g, 3.0 mmol, 1 .5 molar eq.) were added under argon. The mixture was stirred for 20 minutes at 80 °C and cooled to room temperature. The crude product was isolated by column chromatography on silica gel (toluene ->ethyl acetate/cyclohexane 2:8). The green fraction was collected and concentrated to dryness. The residue was dissolved in methylene chloride and excess methanol was added. The methylene chloride was slowly removed under reduced pressure. The resulting precipitate was filtered off and washed with cold methanol to give a green crystalline solid - the 2dd precatalyst (0.750 g, 56%).

¹ H NMR (CD,Ck 500 MHz): δ = 16.97 (s, 1 H), 8.40 (dd, J = 8.3; 1 .4 Hz, 2H), 7.67-7.57 (m, 4H), 7.50- 7.46 (m, 1 H), 7.46-7.38 (m, 3H), 7.17-7.12 (m, 1 H), 6.71 (dd, J = 7.7; 1 .6 Hz, 1 H), 4.30 (ddd, J = 12.3; 1 1 .3; 2.0 Hz, 1 H), 3.89 (ddt, J = 12.1 ; 2.8; 1 .4 Hz, 1 H), 3.68 (dd, J = 1 1 .2; 2.1 Hz, 1 H), 3.52-3.45 (m, 1 H), 3.45-3.39 (m, 1 H), 3.23 (dd, J = 1 1 .2; 2.1 Hz, 1 H), 3.16 (d, J = 12.5 Hz, 1 H), 2.92 (td, J = 1 1 .2; 3.1 Hz, 1 H), 2.85-2.75 (m, 2H), 2.72-2.58 (m, 2H), 2.49 (dq, J = 14.9; 7.4 Hz, 1 H), 2.33 (d, J = 12.5 Hz, 1 H), 2.30 (s, 3H), 1 .52 (s, 3H), 1 .40 (s, 3H), 1 .08 (t, J = 7.4 Hz, 3H), 0.75 (t, J = 7.4 Hz, 3H).

¹³ C NMR (CD Ck 125 MHz): δ = 307.0. 263.6, 153.4, 149.2, 146.1 , 143.9, 143.6, 139.1 , 130.4, 130.1 , 129.5, 129.4, 128.1 , 127.9, 127.6, 127.1 , 124.9, 123.0, 79.0, 67.3, 67.2, 65.0, 56.1 , 55.7, 46.8, 31 .6, 29.4, 27.4, 26.2, 24.5, 15.3, 14.5.

HRMS: ESI was calculated for Ca^NsONaClsRu [M+Na] ⁺ : 689.1 615; found: 689.1595.

Elemental analysis: calculated for C34H42N2OCI2RU :

C 61 .25; H 6.35; N 4.20; CI 10.64; found: C 61 .12; H 6.37; N 4.21 ; CI 1 0.80.

Example XXVIII

Reaction for preparing complex 2ed

To the suspension of complex 3 ( ^" I .OO g, 1 .0 mmol, 1 molar eq.) in dry deoxygenated dioxane (1 0 ml) benzylidene ligand e (0.488 g, 2.0 mmol, 2 molar eq.) was added under argon. The mixture was stirred for 30 minutes at 80 °C and cooled to room temperature. This was filtered off and washed with dioxane. A green crystalline solid was obtained - the precatalyst 2ed (0.585 g, 83%).

¹ H NMR (CD ₂ Ck 500 MHz): δ = 17.40 (s, 1 H), 8.26-8.21 (m, 2H), 7.58-7.52 (m, 2H), 7.44-7.39 (m, 2H), 7.36-7.33 (m, 1 H), 7.26 (td, J = 7.5; 1 .6 Hz, 1 H), 7.18 (td, J = 7.4; 1 .0 Hz, 1 H), 7.07 (t, J = 7.7 Hz, 1 H), 6.80 (dd, J = 7.6; 1 .6 Hz, 1 H), 6.33 (d, J = 7.7 Hz, 1 H), 3.26 (dq, J = 15.1 ; 7.4 Hz, 1 H), 2.97 (d, J = 13.4 Hz, 1 H), 2.66 (s, 3H), 2.57 (dq, = 1 5.0; 7.3 Hz, 1 H), 2.38 (d, J = 13.4 Hz, 1 H), 2.02 (dq, J = 14.7; 7.3 Hz, 1 H), 1 .62 (dq, J = 1 5.0; 7.5 Hz, 1 H), 1 .51 (s, 3H), 1 .42 (t, J = 7.4 Hz, 3H), 1 .26 (s, 3H), 0.90 (t, J = 7.4 Hz, 3H).

¹³ C NMR (CD Ck 125 MHz): δ = 282.9, 282.8, 267.5, 158.3, 145.5, 142.7, 141 .3, 136.9, 134.4, 131 .7, 131 .2, 129.5, 129.3, 128.8, 127.1 , 126.7, 126.1 , 102.2, 80.3, 62.4, 50.2, 30.8, 30.2, 29.0, 25.8, 25.6, 1 5.2, 14.1 .

HRMS: ESI was calculated for C30H34NCIRUI [M-CI] ⁺ : 672.0468; found: 672.0455.

Elemental analysis: calculated for C30H34NCI2I RU :

C 50.93; H 4.84; N 1 .98; CI 10.02; I 17.94; found: C 51 .01 ; H 4.98; N 2.03; CI 10.01 ; I 17.71 .

Example XIX

RCM reaction of diethyl diallylmalonate (S3)

To a solution of S3 (0.240 g, 1 .0 mmol) in toluene (10 ml) at 29°C or 40°C or 80°C, the precatalyst solution (0.1 mol%) in toluene (50 μΙ) was added in one portion. At required intervals, samples were taken of the reaction mixture to which a few drops of ethyl vinyl ether were added to deactivate the catalyst. The samples were analysed by gas chromatography.

S3 P7

Table 14. Experimental results of the CM reaction of methyl acrylate with S1

Conversion [%]

Time [min] 29°C 40°C 80°C

2ed 2dd 2dd Conversion [%]

Time [min] 29°C 40°C 80°C

2ed 2dd 2dd

2.5 58 - 4

5 89 - 10

10 99 0.5 28

20 99.5 - 62

30 - - 78

45 - - 85

60 - 2.3 88

Metathesis products analytical data

P1:

main isomer, E: ¹ H NMR (CDCk 500 MHz): <5 = 6.95 (dt, J= 15.7; 7.0 Hz, 1H), 5.83-5.77 (dt, J= 15.6; 1.6 Hz, 1 H) 5.80 (dt, J = 15.6; 1.6 Hz, 1 H), 4.10 (q, J= 7.2 Hz, 2H), 3.71 (s, 3H), 2.26 (t, J = 7.5 Hz, 2H), 2.17 (qd, J = 7.1 ; 1.6 Hz, 2H), 1.64-1.54 (m, 2H), 1.47-1.38 (m, 2H), 1.33-1.25 (m, 8H), 1.23 (t, J = 7.1 Hz, 3H).

¹³ C NMR (CDCk 125 MHz): <5= 173.8, 167.1, 149.7, 120.8, 60.1, 51.3, 34.3, 32.1 , 29.1 , 29.1 , 29.0, 29.0, 27.9, 24.9, 14.1)

P2:

main isomer, Z: ¹ H NMR (CDCk 500 MHz): δ = 6.46 (s, 1 H), 8.48 (dd, J = 10.9; 7.7 Hz, 1 H), 5.29 (d, J = 2.8 Hz, 1 H), 7.20 (s, 2H), 4.10 (d, J= 7.1 Hz, 1 H), 2.40 (septet, J = 1.4 Hz, 1 H), 2.26 (s, 3H), 1.64 (s, 2H), 1.49 (s, 6H), 1.35 (s, 6H), 1.23 (d, J = 7.1 Hz, 6H), 1.43 (s, 6H).

¹³ C NMR (CDCk 125 MHz): δ= 173,8, 156.0 (£), 155.1 (Z), 117.5 (£), 116.0 (Z), 99.6 (£), 99.4 (Z), 60.1 (2C, E+Z), 34.3 (Z), 34.2 (£), 33.2 (£), 31.8 (Z), 29.0 (6C, E+Z), 28.9 (Z), 28.8 (£), 28.1 (Z), 27.5 (£), 24.9 (Z), 24.8 (£), 14.2.

P3:

main isomer, Z: ¹ H NMR (CDCk 500 MHz): δ = 6.46 (dt, J = 10.9; 7.7 Hz, 1 H), 5.29 (dt, J = 10.9; 1.3 Hz, 1 H), 3.65 (s, 3H), 2.40 (dq, J = 7.6; 1.3 Hz, 2H), 2.29 (t, J = 7.5 Hz, 2H), 1.64-1.54 (m, 2H), 1.50-1.39 (m, 2H), 1.36-1.26 (m, 6H).

¹³ C NMR (CDCk 125 MHz): δ= 174.12 (Z), 174.08 (£), 156.0 (£), 155.0 (Z), 117.5 (£), 116.0 (Z), 99.6 (£), 99.5 (Z), 51.39 (£), 51.37 (Z), 33.95 (Z), 33.92 (£), 33.2 (E) 31.7 (Z), 28.87 (Z), 28.85 (£), 28.83 (Z+£), 28.72 (Z), 28.68 (£), 28.1 (Z), 27.5 (£), 24.77 (Z), 24.75 (£).

P4:

main isomer, Z: ¹ H NMR (CDCk 500 MHz): δ = 6.47 (dt, J = 10.9; 7.7 Hz, 1 H), 5.29 (dt, J = 11.0; 1.4 Hz, 1 H), 2.41 (qd, J = 7.5; 1.4 Hz, 2H), 1.50-1.38 (m, 2H), 1.37-1.21 (m, 10H), 0.87 (t, J = 7.0 Hz, 3H).

¹³ C NMR (126 MHz. CDC ): δ= 156.1 (£), 155.2 (Z), 117.5 (£), 116.0 (Z), 99.6 (£), 99.4 (Z), 33.3 (Z), 31.8 (£), 31.7.29.2 (2C, Z+E), 29.1 (2C, Z+E), 29.0 (Z), 28.9 (E), 28.2 (Z), 27.6 (E), 22.6.14.0.

P5: ¹ H NMR (CDC .500 MHz): δ = 5.79 (ddt, J= 17.0; 10.2; 6.7 Hz, 1H), 4.98 (dq, J= 17.1; 1.7 Hz, 1H), 4.92 (ddd, J = 11.4; 2.3; 1.2 Hz, 1H), 3.66 (s, 3H), 2.29 (t, J= 7.5 Hz, 2H), 2.06-1.99 (m, 2H), 1.66-1.56 (m, 2H), 1.40-1.24 (m, 8H).

¹³ C NMR (CDCk 125 MHz): 174.3.139.1.114.2.51.4.34.1.33.7.29,1.28,9, 28,8, 24.9.

D1:

¹ H NMR fCDCk 600 MHz): δ = 5.41-5.30 (m, 2H), 4.14-4.08 (m, 4H), 2.30-2.24 (m, 4H), 2.02-1.90 (m, 4H), 1.64-1.56 (m, 4H), 1.35-1.21 (m, 26H).

¹³ C NMR (CDCk 150 MHz): <5= 173.8, 130.3.60.1.34.4.32.5.29.6.29.3.29.2.29.1.29.0.24.9, 14.2. D2:

¹ H NMR fCDCk 500 MHz): <5= 5.36 (ddd, J= 5.3; 3.7; 1.6 Hz, 2H, £), 5.32 (ddd, J = 5.7; 4.3; 1.1 Hz, 2H, Z), 3.65 (s, 6H), 2.29 (t, J = 7.5 Hz, 4H), 2.03-1.90 (m, 4H), 1.68-1.56 (m, 4H), 1.35-1.23 (m, 16H).

¹³ C NMR (CDC . 125 MHz): <5= 174.25 (£), 174.24 (Z), 130.3 (£), 129.8 (Z), 51.4.34.1.32.5.29.6 (Z), 29.5 (£), 29.12 (Z), 29.08 (£), 29.07 (£), 29.05 (Z), 28.9, 27.1(2), 24.9 (£).

D3:

¹ H NMR (CDCk 500 MHz): <5= 5.39 (ddd, J= 5.3; 3.7; 1.6 Hz, 2H, £), 5.35 (ddd, J= 5.7; 4.4; 1.1 Hz, 2H, Z), 2.06-1.91 (m, 4H), 1.38-1.18 (m, 24H), 0.88 (t, J= 6,9 Hz, 6H).

¹³ C NMR (CDCU.125 MHz): <5= 130.4 (£), 129.9 (Z), 32.6, 31.9, 29.8 (Z), 29.7 (£), 29.53 (Z), 29.51 (£), 29.3.29.2 (£), 27.2 (Z), 22.7, 14.1.

"The project leading to this application has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 635405".