Title:
USE OF SILDENAFIL AND ROCK INHIBITORS FOR TREATING STROKE OR SEQUELAE FOLLOWING STROKE
Document Type and Number:
WIPO Patent Application WO/2021/095945
Kind Code:
A1
Abstract:
The present invention relates to a use of a pharmaceutical composition for treating stroke or sequelae following stroke, the composition comprising a phosphodiesterase type 5 activity inhibitor and a Rho-associasted kinase (ROCK) inhibitor. The present inventors have performed research, based on clinical knowledge related to stroke treatment, in order to use sildenafil and a ROCK inhibitor in combination to treat stroke or sequelae caused by stroke, and as a result, confirmed for the first time that stroke or sequelae caused by stroke were significantly improved when sildenafil and a ROCK inhibitor were administered in combination compared to when sildenafil or the ROCK inhibitor was administered by itself. Therefore, it is expected that a pharmaceutical composition according to the present invention will be able to be effectively used for treating or studying stroke or stroke-related sequelae.
Inventors:
OH JAE-SANG (KR)
KIM DUK-SOO (KR)
LEE MAN-RYUL (KR)
KANG JUHYEON (KR)
KIM DUK-SOO (KR)
LEE MAN-RYUL (KR)
KANG JUHYEON (KR)
Application Number:
PCT/KR2019/015662
Publication Date:
May 20, 2021
Filing Date:
November 15, 2019
Export Citation:
Assignee:
UNIV SOONCHUNHYANG IND ACAD COOP FOUND (KR)
International Classes:
A61K31/519; A61K31/4439; A61K31/4985; A61K31/551; A61K45/06; A61P7/02; A61P9/10; A61P25/22
Foreign References:
| KR20140072819A | 2014-06-13 | |||
| US20030176413A1 | 2003-09-18 | |||
| KR20070098911A | 2007-10-05 |
Other References:
SHIN, HWA KYEONG: "Combination Therapy of Normobaric Hyperoxia and Rho-kinase Inhibitor in Focal Cerebra Ischemia", FINAL REPORT ON NATION RESEARCH AND DEVELOPMENT PROJECT, 13 January 2014 (2014-01-13), pages 1 - 9
SHIBUYA, M; HIRAI S; SETO M; SATOH S I; OHTOMO E: "Effects of fasudil in acute ischemic stroke : results of a prospective placebo-control led double-blind tria l", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 238, 2005, pages 31 - 39, XP027712909
SHIBUYA, M; HIRAI S; SETO M; SATOH S I; OHTOMO E: "Effects of fasudil in acute ischemic stroke : results of a prospective placebo-control led double-blind tria l", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 238, 2005, pages 31 - 39, XP027712909
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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