Title:
USE OF SRE-PTPRZ1 INHIBITOR IN PREPARATION OF DRUG FOR TREATING SQUAMOUS CELL CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2023/237122
Kind Code:
A1
Abstract:
A use of an SRE-PTPRZ1 inhibitor or a PTPRZ1 inhibitor in the preparation of a drug for treating squamous cell carcinoma. The SRE-PTPRZ1 inhibitor is an inhibitor for SRE-PTPRZ1 structural variation, the SRE-PTPRZ1 structural variation being somatic simple repeat expansion at insertion site GRCh38 chr7: 121603263-121603506, the repeating pattern of an insertion region and a somatic cell simple repeat expansion sequence are (CTTT)n, wherein 10 ≤ n < 500; the PTPRZ1 inhibitor one of the followings compounds, a pharmaceutically acceptable salt thereof, one or two derivatives among derivatives thereof, or a mixture of the above: NAZ2329, SCB4380, MY-33-3, or MY-10; and the HGNC number of the PTPRZ1 gene is 9685.
Inventors:
LI WEIMIN (CN)
XIE DAN (CN)
WANG ZHOUFENG (CN)
XIA LIN (CN)
DENG YAN (CN)
PI XUENAN (CN)
WANG HUAN (CN)
ZENG TIANFU (CN)
XIE DAN (CN)
WANG ZHOUFENG (CN)
XIA LIN (CN)
DENG YAN (CN)
PI XUENAN (CN)
WANG HUAN (CN)
ZENG TIANFU (CN)
Application Number:
PCT/CN2023/099586
Publication Date:
December 14, 2023
Filing Date:
June 12, 2023
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
A61K31/18; A61K31/075; A61K31/135; A61K31/185; A61P35/00
Foreign References:
| CN108893534A | 2018-11-27 | |||
| CN106591306A | 2017-04-26 |
Other References:
YAN-HE HU, ZHANG XIAO-PING, HU BO, LIU JUN: "Expression and Correlation of Tyrosine Phosphatase Z1 Receptor,Cyclooxygenase-2 and Human Telomerase Reverse Transcriptase in Oral Submucous Fibrocarcinogenesis", PROGRESS IN MODERN BIOMEDICINE, vol. 21, no. 11, 15 June 2021 (2021-06-15), pages 2018 - 2022, XP093114377, DOI: 10.13241/j.cnki.pmb.2021.11.004
FUJIKAWA AKIHIRO, NAGAHIRA ASAKO, SUGAWARA HAJIME, ISHII KENTARO, IMAJO SEIICHI, MATSUMOTO MASAHITO, KUBOYAMA KAZUYA, SUZUKI RYOKO: "Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 6, no. 1, 9 February 2016 (2016-02-09), US , pages 20473, XP093114378, ISSN: 2045-2322, DOI: 10.1038/srep20473
RONG ZHU, JIAN XIN-CHUN, LIU DE-YU, ZHOU CHAO, WANG YUAN: "Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance", SHANGHAI JOURNAL OF STOMATOLOGY, vol. 26, no. 2, 15 April 2017 (2017-04-15), pages 198 - 203, XP093114379, DOI: 10.19439/j.sjos.2017.02.015
FUJIKAWA AKIHIRO, NAGAHIRA ASAKO, SUGAWARA HAJIME, ISHII KENTARO, IMAJO SEIICHI, MATSUMOTO MASAHITO, KUBOYAMA KAZUYA, SUZUKI RYOKO: "Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 6, no. 1, 9 February 2016 (2016-02-09), US , pages 20473, XP093114378, ISSN: 2045-2322, DOI: 10.1038/srep20473
RONG ZHU, JIAN XIN-CHUN, LIU DE-YU, ZHOU CHAO, WANG YUAN: "Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance", SHANGHAI JOURNAL OF STOMATOLOGY, vol. 26, no. 2, 15 April 2017 (2017-04-15), pages 198 - 203, XP093114379, DOI: 10.19439/j.sjos.2017.02.015
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) CHENGDU (CN)
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