USE OF STEROIDAL ALKALOIDS TO REVERSE MULTIDRUG RESISTANCE

Title:

USE OF STEROIDAL ALKALOIDS TO REVERSE MULTIDRUG RESISTANCE

Document Type and Number:

WIPO Patent Application WO2001049279

Kind Code:

A3

Abstract:

The invention provides steroidal alkaloids for inhibiting or reversing multidrug resistance in cancer or in bacterial, fungal or parasitic infections. The steroidal alkaloid may be administered to the patient alone or in combination with an anticancer, antibacterial, antifungal or antiparasitic agent. Examples of steroidal alkaloids include members of the solanidane or spirosolane e.g. tomatidine, families, and C-nor-D-homo steroid such as of the jervane or veratramine families.

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Inventors:

LISCOVITCH MORDECHAI (IL)
LAVIE YAAKOV (IL)

Application Number:

PCT/IL2000/000866

Publication Date:

October 17, 2002

Filing Date:

December 28, 2000

Export Citation:

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Assignee:

YEDA RES & DEV (IL)
LISCOVITCH MORDECHAI (IL)
LAVIE YAAKOV (IL)

International Classes:

A61K31/337; A61K31/437; A61K31/4525; A61K31/475; A61K31/513; A61K31/519; A61K31/58; A61K31/704; A61K31/445; A61K31/706; A61K33/24; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; (IPC1-7): A61K31/706; A61K31/58; A61K45/06; A61K35/78; A61P35/00; A61P31/04; A61P31/10; A61P31/12

Domestic Patent References:

WO1999052534A1	1999-10-21
WO1998058543A1	1998-12-30
WO1997027211A1	1997-07-31

Foreign References:

EP0020029A1	1980-12-10
EP0361485A2	1990-04-04

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