Title:
USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2003007930
Kind Code:
A3
Abstract:
This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic hydroxamic acid, a derivative thereof, or a pharmaceutically acceptable salt of the hydroxamic acid or derivative to a host animal. The compound generally corresponds in structure to the following formula: , wherein W and the R groups are described in more detail in Applicants' specification.
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Inventors:
MCDONALD JOSEPH J (US)
BARTA THOMAS A (US)
ARNER ELIZABETH (US)
BOEHM TERRI L (US)
BECKER DANIEL P (US)
DECRESCENZO GARY A (US)
BARTA THOMAS A (US)
ARNER ELIZABETH (US)
BOEHM TERRI L (US)
BECKER DANIEL P (US)
DECRESCENZO GARY A (US)
Application Number:
PCT/US2002/022867
Publication Date:
August 21, 2003
Filing Date:
July 19, 2002
Export Citation:
Assignee:
PHARMACIA CORP (US)
MCDONALD JOSEPH J (US)
BARTA THOMAS A (US)
ARNER ELIZABETH (US)
BOEHM TERRI L (US)
BECKER DANIEL P (US)
DECRESCENZO GARY A (US)
MCDONALD JOSEPH J (US)
BARTA THOMAS A (US)
ARNER ELIZABETH (US)
BOEHM TERRI L (US)
BECKER DANIEL P (US)
DECRESCENZO GARY A (US)
International Classes:
C07D295/22; A61K31/16; A61K31/18; A61K31/40; A61K31/44; A61K31/4439; A61K31/445; A61K31/451; A61K31/4525; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/4965; A61P1/02; A61P1/04; A61P1/16; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/08; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P33/06; A61P35/00; A61P35/04; A61P37/06; A61P39/00; A61P43/00; C07D207/48; C07D211/96; C07D401/04; C07D401/12; C07D405/12; C07D407/14; C07D409/12; (IPC1-7): A61K31/445; A61K31/16; A61K31/18; A61K31/40; A61K31/44; A61K31/495; A61P1/16; A61P19/00; A61P19/02
Domestic Patent References:
| WO2001085680A2 | 2001-11-15 | |||
| WO2000069819A1 | 2000-11-23 | |||
| WO2000056704A1 | 2000-09-28 |
Other References:
BARTA ET AL.: "Synthesis and activity of selective MMP inhibitors with an aryl backbone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 24, 18 December 2000 (2000-12-18), pages 2815 - 2817, XP004225358, ISSN: 0960-894X
BARTA, T. E. ET AL: "Selective, orally active MMP inhibitors with an aryl backbone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 18, 17 September 2001 (2001-09-17), pages 2481 - 2483, XP002222556
BARTA, T. E. ET AL: "Selective, orally active MMP inhibitors with an aryl backbone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 18, 17 September 2001 (2001-09-17), pages 2481 - 2483, XP002222556
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