Title:
USE OF TRIAZOLOTRIAZINE DERIVATIVE IN TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/129843
Kind Code:
A1
Abstract:
The present application relates to use of a triazolotriazine derivative or a pharmaceutically acceptable solvate or salt thereof in the preparation of a drug for treating diseases, and a method for treating diseases.
Inventors:
SUN SANXING (CN)
CHEN ZHENGSHU (CN)
YE JINQI (CN)
ZHAO LONG (CN)
HU CHONGBO (CN)
YANG YONG (CN)
GUAN FENG (CN)
PAN SHUHUA (CN)
HU NING (CN)
PAN TINGTING (CN)
SONG GUOWEI (CN)
HOU FANGJIE (CN)
CHEN ZHENGSHU (CN)
YE JINQI (CN)
ZHAO LONG (CN)
HU CHONGBO (CN)
YANG YONG (CN)
GUAN FENG (CN)
PAN SHUHUA (CN)
HU NING (CN)
PAN TINGTING (CN)
SONG GUOWEI (CN)
HOU FANGJIE (CN)
Application Number:
PCT/CN2020/139690
Publication Date:
July 01, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
ZHEJING VIMGREEN PHARMACEUTICALS LTD (CN)
International Classes:
C07D487/04; A61K31/53; A61P25/16; A61P35/00
Domestic Patent References:
| WO2002031499A1 | 2002-04-18 |
Foreign References:
| CN1056879A | 1991-12-11 | |||
| US5380714A | 1995-01-10 | |||
| CN111051309A | 2020-04-21 | |||
| CN111164084A | 2020-05-15 | |||
| CN1056879A | 1991-12-11 | |||
| US5380714A | 1995-01-10 |
Other References:
SIHVER, W. BIER, D. HOLSCHBACH, M.H. SCHULZE, A. WUTZ, W. OLSSON, R.A. COENEN, H.H.: "Binding of tritiated and radioiodinated ZM241,385 to brain A"2"A adenosine receptors", NUCL. MED. BIOL., ELSEVIER, NY., US, vol. 31, no. 2, 1 February 2004 (2004-02-01), US, pages 173 - 177, XP004495502, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2003.10.007
JÖRG MANUELA; SHONBERG JEREMY; MAK FRANKIE S.; MILLER NEIL D.; YURIEV ELIZABETH; SCAMMELLS PETER J.; CAPUANO BEN: "Novel adenosine A2Areceptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2Areceptor antagonists for extending into extracellular space", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 11, 2 April 2013 (2013-04-02), AMSTERDAM, NL, pages 3427 - 3433, XP028535132, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.070
ROBERTD. LEONE;LEISHAA. EMENS: "Targeting adenosine for cancer immunotherapy", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 18 June 2018 (2018-06-18), London, UK, pages 1 - 9, XP021257599, DOI: 10.1186/s40425-018-0360-8
JÖRG MANUELA; SHONBERG JEREMY; MAK FRANKIE S.; MILLER NEIL D.; YURIEV ELIZABETH; SCAMMELLS PETER J.; CAPUANO BEN: "Novel adenosine A2Areceptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2Areceptor antagonists for extending into extracellular space", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 11, 2 April 2013 (2013-04-02), AMSTERDAM, NL, pages 3427 - 3433, XP028535132, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.070
SIHVER, W. BIER, D. HOLSCHBACH, M.H. SCHULZE, A. WUTZ, W. OLSSON, R.A. COENEN, H.H.: "Binding of tritiated and radioiodinated ZM241,385 to brain A"2"A adenosine receptors", NUCL. MED. BIOL., ELSEVIER, NY., US, vol. 31, no. 2, 1 February 2004 (2004-02-01), US, pages 173 - 177, XP004495502, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2003.10.007
HOEHN MMYAHR MD: "Parkinsonism: onset, progression and mortality", NEUROLOGY, vol. 17, 1967, pages 427 - 42
PERKIN TRANS, J. CHEM. SOC., vol. 1, 1995, pages 801 - 808
STRUCTURAL CHEMISTRY, vol. 24, 2013, pages 1241 - 1251
BECKER, J NEUROL, vol. 249, no. 111, 2002, pages 40
PRUNIER C ET AL., NEUROIMAGE, vol. 19, no. 3, July 2003 (2003-07-01), pages 810 - 6
STEM, ANNALS OF NEUROL, vol. 56, 2004, pages 169
"Unified Scoring Scale for Parkinson's Disease (UPDRS"
See also references of EP 4083044A4
JÖRG MANUELA; SHONBERG JEREMY; MAK FRANKIE S.; MILLER NEIL D.; YURIEV ELIZABETH; SCAMMELLS PETER J.; CAPUANO BEN: "Novel adenosine A2Areceptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2Areceptor antagonists for extending into extracellular space", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 11, 2 April 2013 (2013-04-02), AMSTERDAM, NL, pages 3427 - 3433, XP028535132, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.070
ROBERTD. LEONE;LEISHAA. EMENS: "Targeting adenosine for cancer immunotherapy", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 18 June 2018 (2018-06-18), London, UK, pages 1 - 9, XP021257599, DOI: 10.1186/s40425-018-0360-8
JÖRG MANUELA; SHONBERG JEREMY; MAK FRANKIE S.; MILLER NEIL D.; YURIEV ELIZABETH; SCAMMELLS PETER J.; CAPUANO BEN: "Novel adenosine A2Areceptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2Areceptor antagonists for extending into extracellular space", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 11, 2 April 2013 (2013-04-02), AMSTERDAM, NL, pages 3427 - 3433, XP028535132, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.03.070
SIHVER, W. BIER, D. HOLSCHBACH, M.H. SCHULZE, A. WUTZ, W. OLSSON, R.A. COENEN, H.H.: "Binding of tritiated and radioiodinated ZM241,385 to brain A"2"A adenosine receptors", NUCL. MED. BIOL., ELSEVIER, NY., US, vol. 31, no. 2, 1 February 2004 (2004-02-01), US, pages 173 - 177, XP004495502, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2003.10.007
HOEHN MMYAHR MD: "Parkinsonism: onset, progression and mortality", NEUROLOGY, vol. 17, 1967, pages 427 - 42
PERKIN TRANS, J. CHEM. SOC., vol. 1, 1995, pages 801 - 808
STRUCTURAL CHEMISTRY, vol. 24, 2013, pages 1241 - 1251
BECKER, J NEUROL, vol. 249, no. 111, 2002, pages 40
PRUNIER C ET AL., NEUROIMAGE, vol. 19, no. 3, July 2003 (2003-07-01), pages 810 - 6
STEM, ANNALS OF NEUROL, vol. 56, 2004, pages 169
"Unified Scoring Scale for Parkinson's Disease (UPDRS"
See also references of EP 4083044A4
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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