Title:
USE OF TRIMANGANESE TETRAOXIDE PARTICLES IN PREPARATION OF VACCINE ADJUVANT
Document Type and Number:
WIPO Patent Application WO/2023/131356
Kind Code:
A3
Abstract:
Disclosed is a use of trimanganese tetraoxide particles in preparation of a vaccine adjuvant. The adjuvant is a particle adjuvant, the particle adjuvant is trimanganese tetraoxide particles externally wrapped with or without an excipient, and the particle size of the particle adjuvant is 5 nm to 3000 nm. The trimanganese tetraoxide particle adjuvant provided in the present invention can be effectively combined with a single-stranded nucleotide adjuvant and can effectively carry an immune antigen, and a more excellent immunotherapy effect can be achieved when a fewer antigen dose and a relatively low injection amount are used; immune cells are efficiently activated, and body fluid balance and cellular immunity are achieved.
Inventors:
WANG YALING (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
Application Number:
PCT/CN2023/079905
Publication Date:
August 24, 2023
Filing Date:
March 06, 2023
Export Citation:
Assignee:
THE GBA NAT INSTITUTE FOR NANOTECHNOLOGY INNOVATION (CN)
International Classes:
A61K39/39; A61P37/04
Foreign References:
| CN114432437A | 2022-05-06 | |||
| CN112791181A | 2021-05-14 | |||
| CN107456575A | 2017-12-12 | |||
| CN113797329A | 2021-12-17 | |||
| CN113274492A | 2021-08-20 | |||
| AU2008200021A1 | 2008-01-31 | |||
| CA3168783A1 | 2021-09-10 | |||
| CN109939229A | 2019-06-28 |
Other References:
DING XIAOFENG, WANG JUNWEI, CHEN SIXUE, YANG YANG, WANG YICUN, MA JINBAO: "A Discussion on Application and Development of Mn 3 O 4", CHINA'S MANGANESE INDUSTRY., vol. 37, no. 1, 1 February 2019 (2019-02-01), pages 1 - 3, XP093086097, DOI: 10.14101/j.cnki.issn.1002-4336.2019.01.001
ZHANG YUN, MENG DEHUI, SHI JINJIN, ZHANG ZHENZHONG, HAO YONGWEI, WANG LEI, ZHANG BINGXIANG, LI DONG, ZHANG HONGLING: "Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 29 April 2019 (2019-04-29), pages 1759 - 1778, XP093086100, DOI: 10.2147/IJN.S98832
ZHANG YUN, MENG DEHUI, SHI JINJIN, ZHANG ZHENZHONG, HAO YONGWEI, WANG LEI, ZHANG BINGXIANG, LI DONG, ZHANG HONGLING: "Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 29 April 2019 (2019-04-29), pages 1759 - 1778, XP093086100, DOI: 10.2147/IJN.S98832
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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