Title:
USE FOR XK AND/OR VPS13A
Document Type and Number:
WIPO Patent Application WO/2023/048299
Kind Code:
A1
Abstract:
Provided is a regulator of cell membrane scrambling (e.g., cell membrane scrambling induced by extracellular ATP stimulation), said regulator containing at least one regulator selected from the group consisting of XK expression regulators, XK function regulators, VPS13A expression regulators, and VPS13A function regulators.
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Inventors:
NAGATA SHIGEKAZU (JP)
RYODEN YUTA (JP)
RYODEN YUTA (JP)
Application Number:
PCT/JP2022/036003
Publication Date:
March 30, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
OTSUKA PHARMA CO LTD (JP)
OTSUKA PHARMA CO LTD (JP)
International Classes:
A61K45/06; A23L33/00; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C12N5/10
Other References:
ZHU XIANG, CHO EUN-SOOK, SHA QUAN, PENG JIANBIN, OKSOV YELENA, KAM SIOK YUEN, HO MENGFATT, WALKER RUTH H., LEE SOOHEE: "Giant Axon Formation in Mice Lacking Kell, XK, or Kell and XK", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 184, no. 3, 1 March 2014 (2014-03-01), US , pages 800 - 807, XP093052396, ISSN: 0002-9440, DOI: 10.1016/j.ajpath.2013.11.013
RYODEN YUTA, SEGAWA KATSUMORI, NAGATA SHIGEKAZU: "Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 119, no. 7, 15 February 2022 (2022-02-15), pages 1 - 9, XP093052399, ISSN: 0027-8424, DOI: 10.1073/pnas.2119286119
SASSENBACH LUKAS: "Identification of novel proteins involved in P2X7-mediated signaling cascades", PURINERGIC SIGNALLING, vol. 18, no. 4, 1 December 2022 (2022-12-01), DE , pages 495 - 498, XP093052404, ISSN: 1573-9538, DOI: 10.1007/s11302-022-09893-z
RYODEN YUTA, SEGAWA KATSUMORI, NAGATA SHIGEKAZU: "Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 119, no. 7, 15 February 2022 (2022-02-15), pages 1 - 9, XP093052399, ISSN: 0027-8424, DOI: 10.1073/pnas.2119286119
SASSENBACH LUKAS: "Identification of novel proteins involved in P2X7-mediated signaling cascades", PURINERGIC SIGNALLING, vol. 18, no. 4, 1 December 2022 (2022-12-01), DE , pages 495 - 498, XP093052404, ISSN: 1573-9538, DOI: 10.1007/s11302-022-09893-z
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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