Title:
USES OF GLUCOCORTICOID RECEPTOR (GR) ANTAGONIST AND ANDROGEN RECEPTOR (AR) DEGRADER COMBINATIONS
Document Type and Number:
WIPO Patent Application WO/2022/031642
Kind Code:
A3
Abstract:
Disclosed herein are methods of treating prostate cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of (i) a glucocorticoid receptor (GR) antagonist and (ii) an androgen receptor (AR) degrader.
Inventors:
ZHOU HAIYING (US)
DAEMEN ANNELEEN (US)
BARKUND SHRAVANI (US)
FRIEDMAN LORI S (US)
DAEMEN ANNELEEN (US)
BARKUND SHRAVANI (US)
FRIEDMAN LORI S (US)
Application Number:
PCT/US2021/044255
Publication Date:
March 17, 2022
Filing Date:
August 03, 2021
Export Citation:
Assignee:
ORIC PHARMACEUTICALS INC (US)
International Classes:
A61K31/4745; A61K31/513; A61K31/567
Domestic Patent References:
| WO2017112902A1 | 2017-06-29 |
Foreign References:
| US20180099940A1 | 2018-04-12 |
Other References:
REW ET AL.: "Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101", J. MED. CHEM., vol. 61, 2018, pages 7767 - 7784, XP055605922, DOI: 10.1021/acs.jmedchem.8b00743
ISIKBAY ET AL.: "Glucocorticoid Receptor Activity Contributes to Resistance to Androgen- Targeted Therapy in Prostate Cance r", HORM CANC ., vol. 5, 2014, pages 72 - 89, XP055544154, DOI: 10.1007/s12672-014-0173-2
ISIKBAY ET AL.: "Glucocorticoid Receptor Activity Contributes to Resistance to Androgen- Targeted Therapy in Prostate Cance r", HORM CANC ., vol. 5, 2014, pages 72 - 89, XP055544154, DOI: 10.1007/s12672-014-0173-2
Attorney, Agent or Firm:
SMITH, Deborah (US)
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