Title:
USING A CYTOKINE SIGNATURE TO DIAGNOSE DISEASE OR INFECTION
Document Type and Number:
WIPO Patent Application WO/2012/106674
Kind Code:
A3
Abstract:
Provided are methods and compositions for detection of levels, activity, or expression of cytokines so as to determine a cytokine signature. A cytokine signature of a subject can be compared to a control or reference value(s) and differences there between used in the diagnosis or monitoring of a neuroimmune disease or a retroviral infection.
More Like This:
Inventors:
LOMBARDI VINCENT C (US)
MIKOVITS JUDY A (US)
MIKOVITS JUDY A (US)
Application Number:
PCT/US2012/023876
Publication Date:
April 24, 2014
Filing Date:
February 03, 2012
Export Citation:
Assignee:
WHITTEMORE PETERSON INST FOR NEURO IMMUNE DISEASE (US)
LOMBARDI VINCENT C (US)
MIKOVITS JUDY A (US)
LOMBARDI VINCENT C (US)
MIKOVITS JUDY A (US)
International Classes:
A61K45/00; C12Q1/68
Other References:
PETERSON ET AL.: "Differences in cytokine and chemokine responses during neurological disease induced by polytropic murine retroviruses Map to separate regions of the viral envelope gene.", J VIROL, vol. 75, no. 6, March 2001 (2001-03-01), pages 2848 - 2856
LI ET AL.: "Neurodegeneration Induced by PVC-211 Murine Leukemia Virus Is Associated with Increased Levels of Vascular Endothelial Growth Factor and Macrophage Inflammatory Protein 1 alpha and Is Inhibited by Blocking Activation of Microglia.", J VIROL, vol. 83, no. 10, May 2009 (2009-05-01), pages 4912 - 4922
LI ET AL.: "Neurodegeneration Induced by PVC-211 Murine Leukemia Virus Is Associated with Increased Levels of Vascular Endothelial Growth Factor and Macrophage Inflammatory Protein 1 alpha and Is Inhibited by Blocking Activation of Microglia.", J VIROL, vol. 83, no. 10, May 2009 (2009-05-01), pages 4912 - 4922
Attorney, Agent or Firm:
METZGER, David R. (P.O. BOX 061080Wacker Drive Station, Willis Towe, Chicago Illinois, US)
Download PDF: