Title:
USP7 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/048498
Kind Code:
A1
Abstract:
The present application relates to a USP7 inhibitor as represented by formula (I), a preparation method therefor, and the use thereof in treating tumor diseases. In the preparation process, the compound of the present invention is obtained by means of a series of reactions such as substitution, coupling, reduction, and deprotection.
Inventors:
HOU DENG (CN)
YUAN BAOKUN (CN)
DUAN XIAOWEI (CN)
WANG JINGHAN (CN)
MIN WANGYANG (CN)
CHEN SANXU (CN)
LIU XIJIE (CN)
LIU SHUANG (CN)
SUN YINGHUI (CN)
YUAN BAOKUN (CN)
DUAN XIAOWEI (CN)
WANG JINGHAN (CN)
MIN WANGYANG (CN)
CHEN SANXU (CN)
LIU XIJIE (CN)
LIU SHUANG (CN)
SUN YINGHUI (CN)
Application Number:
PCT/CN2021/114936
Publication Date:
March 10, 2022
Filing Date:
August 27, 2021
Export Citation:
Assignee:
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
International Classes:
C07D495/04
Domestic Patent References:
| WO2020068600A1 | 2020-04-02 | |||
| WO2020086595A1 | 2020-04-30 |
Foreign References:
| US20210317134A1 | 2021-10-14 | |||
| US20190142834A1 | 2019-05-16 |
Other References:
LEGER PAUL R., HU DENNIS X., BIANNIC BERENGER, BUI MINNA, HAN XINPING, KARBARZ EMILY, MAUNG JACK, OKANO AKINORI, OSIPOV MAKSIM, SH: "Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 10, 28 May 2020 (2020-05-28), US , pages 5398 - 5420, XP055909131, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00245
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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