Title:
UTILIZATION OF THE FUNCTION OF RARE SUGAR AS PROMOTER FOR THE MIGRATION OF GLUCOKINASE FROM NUCLEUS TO CYTOPLASM
Document Type and Number:
WIPO Patent Application WO/2008/059625
Kind Code:
A1
Abstract:
[PROBLEMS] To search for a glucokinase activator from rare sugars and provide a
composition for treating a medical condition relating to the glucokinase activity which
contains the above activator as the active ingredient. [MEANS FOR SOLVING PROBLEMS]
A promoter for the migration of glucokinase from nucleus to cytoplasm which comprises
D-psicose and/or D-tagatose as the active ingredient; or a composition for preventing
or treating the onset of a medical condition relating to the glucokinase activity.
This composition, which comprises D-psicose and/or D-tagatose as the active
ingredient and is usable for preventing or treating the onset of a medical condition
relating to the glucokinase activity, is in a form selected from the group consisting
of a food additive, a food material, a food, a drink, a health food, a health drink,
a drug and a feed. The medical condition relating to the glucokinase activity
is selected from among impaired glucose tolerance, type 2 diabetes, insulin
resistance disease, lipidemia, metabolic syndrome and obesity. The composition
in the form of a drug comprises D-psicose and/or D-tagatose as the active ingredient
together with one or more pharmaceutically acceptable carriers.
Inventors:
TOKUDA MASAAKI (JP)
IZUMORI KEN (JP)
TOYODA YUKIYASU (JP)
MIWA KAZUTOMO (JP)
IZUMORI KEN (JP)
TOYODA YUKIYASU (JP)
MIWA KAZUTOMO (JP)
Application Number:
PCT/JP2007/056445
Publication Date:
May 22, 2008
Filing Date:
March 27, 2007
Export Citation:
Assignee:
UNIV KAGAWA NAT UNIV CORP (JP)
TOKUDA MASAAKI (JP)
IZUMORI KEN (JP)
TOYODA YUKIYASU (JP)
MIWA KAZUTOMO (JP)
TOKUDA MASAAKI (JP)
IZUMORI KEN (JP)
TOYODA YUKIYASU (JP)
MIWA KAZUTOMO (JP)
International Classes:
A61K31/7004; A23L1/30; A61P3/04; A61P3/06; A61P3/10; C07H3/02
Domestic Patent References:
| WO2002058710A1 | 2002-08-01 | |||
| WO2006101118A1 | 2006-09-28 | |||
| WO2003097820A1 | 2003-11-27 | |||
| WO2007010975A1 | 2007-01-25 | |||
| WO2007010976A1 | 2007-01-25 |
Foreign References:
| JPH0665080A | 1994-03-08 | |||
| US5447917A | 1995-09-05 | |||
| US5356879A | 1994-10-18 | |||
| JP2005213227A | 2005-08-11 | |||
| JPH0262887A | 1990-03-02 | |||
| JP2007051137A | 2007-03-01 |
Other References:
MOORE M.C.: "Drug evaluation: tagatose in the treatment of type 2 diabetes and obesity", CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 7, no. 10, October 2006 (2006-10-01), pages 924 - 935, XP003022570
MATSUO T. ET AL.: "Effects of dietary D-psicose on diurnal variation in plasma glucose and insulin concentrations of rats", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 70, no. 9, September 2006 (2006-09-01), pages 2081 - 2085, XP003022571
TOKUDA M.: "Iyaku to shite no Kishoto no Oyo (Application of rare sugars for medical purposes)", THE SOCIETY FOR BIOTECHNOLOGY TAIKAI KOEN YOSHISHU, 2005, pages 25, XP003022572
MATSUO T. ET AL.: "Effects of dietary D-psicose on diurnal variation in plasma glucose and insulin concentrations of rats", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 70, no. 9, September 2006 (2006-09-01), pages 2081 - 2085, XP003022571
TOKUDA M.: "Iyaku to shite no Kishoto no Oyo (Application of rare sugars for medical purposes)", THE SOCIETY FOR BIOTECHNOLOGY TAIKAI KOEN YOSHISHU, 2005, pages 25, XP003022572
Attorney, Agent or Firm:
SUDO, Asako et al. (Kajinoch, Koganei-shi Tokyo 02, JP)
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