Title:
VACCINE COMPOSITIONS, METHODS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/249013
Kind Code:
A9
Abstract:
The present disclosure relates in some aspects to immunogenic compositions including recombinant peptides and proteins comprising influenza virus viral antigens and immunogens, e.g., influenza HA protein peptides. In some aspects, the immunogenic composition comprises a secreted fusion protein comprising a soluble influenza viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. In some aspects, the immunogenic compositions provided herein are useful for generating an immune response, e.g., for treating or preventing an influenza infection. In some aspects, the immunogenic compositions provided herein may be used in a vaccine composition, e.g., as part of a prophylactic and/or therapeutic vaccine. Also provided herein are methods for producing the recombinant peptides and proteins, prophylactic, therapeutic, and/or diagnostic methods, and related kits.
Inventors:
LIANG PENG (CN)
LIANG JOSHUA (CN)
LIANG JOSHUA (CN)
Application Number:
PCT/CN2021/087074
Publication Date:
February 10, 2022
Filing Date:
April 13, 2021
Export Citation:
Assignee:
SICHUAN CLOVER BIOPHARMACEUTICALS INC (CN)
International Classes:
C07K14/11; A61K39/145; A61P31/16; C07K19/00; C12N15/44; C12N15/62
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
Download PDF:
Previous Patent: CORONAVIRUS VACCINE COMPOSITIONS, METHODS, AND USES THEREOF
Next Patent: FOLDABLE ELECTRONIC DEVICE
Next Patent: FOLDABLE ELECTRONIC DEVICE