Title:
VACCINE INCLUDING NONENCAPSULATED STRAIN AS ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2023/048111
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide a vaccine effective in preventing infection by Streptococcus spp. that cause mastitis in livestock, etc. Specifically, the present invention provides a vaccine that contains a nonencapsulated strain of a Streptococcus spp. as an antigen, in particular a vaccine for preventing mastitis caused by Streptococcus uberis infection.
Inventors:
WATANABE ATSUSHI (JP)
HATA EIJI (JP)
GOTO SHINYA (JP)
KAWAI KAZUHIRO (JP)
HATA EIJI (JP)
GOTO SHINYA (JP)
KAWAI KAZUHIRO (JP)
Application Number:
PCT/JP2022/034873
Publication Date:
March 30, 2023
Filing Date:
September 20, 2022
Export Citation:
Assignee:
NAT AGRICULTURE & FOOD RES ORG (JP)
SCHOOL CORPORATION AZABU VETERINARY MEDICINE EDUCATIONAL INST (JP)
SCHOOL CORPORATION AZABU VETERINARY MEDICINE EDUCATIONAL INST (JP)
International Classes:
A61K39/09; A61K39/39; A61P29/00; A61P31/04; A61P37/04; A61P43/00; C07K14/315; C07K16/12
Other References:
KERRO DEGO OUDESSA, ALMEIDA RAUL, IVEY SUSAN, AGGA GETAHUN E.: "Evaluation of Streptococcus uberis Surface Proteins as Vaccine Antigens to Control S. uberis Mastitis in Dairy Cows", VACCINES, M D P I AG, CH, vol. 9, no. 8, 1 August 2021 (2021-08-01), CH , pages 868 - 15, XP093051264, ISSN: 2076-393X, DOI: 10.3390/vaccines9080868
JANG A-YEUNG, SEO HO SEONG, LIN SHUNMEI, CHUNG GOOK-HYUN, KIM HAN WOOL, LIM SANGYONG, ZHAO LEI, PARK IN HO, LIM JAE HYANG, KIM KYU: "Molecular characterization of pneumococcal surface protein K, a potential pneumococcal vaccine antigen", VIRULENCE, LANDES BIOSCIENCE, US, vol. 8, no. 6, 18 August 2017 (2017-08-18), US , pages 875 - 890, XP093051265, ISSN: 2150-5594, DOI: 10.1080/21505594.2016.1278334
J M FINCH, A W HILL, T R FIELD, J A LEIGH: "LOCAL VACCINATION WITH KILLED STREPTOCOCCUS UBERIS PROTECTS THE BOVINE MAMMARY GLAND AGAINST EXPERIMENTAL INTRAMAMMARY CHALLENGE WITH THE HOMOLOGOUS STRAIN", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 62, no. 09, 1 September 1994 (1994-09-01), US , pages 3599 - 3603, XP009052640, ISSN: 0019-9567, DOI: 10.1128/iai.62.9.3599-3603.1994
FIELD TERENCE R., WARD PHILIP N., PEDERSEN LARS H., LEIGH JAMES A.: "The Hyaluronic Acid Capsule of Streptococcus uberis Is Not Required for the Development of Infection and Clinical Mastitis", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 1, 1 January 2003 (2003-01-01), US , pages 132 - 139, XP093051266, ISSN: 0019-9567, DOI: 10.1128/IAI.71.1.132-139.2003
KACZOREK EDYTA, MAŁACZEWSKA JOANNA, WÓJCIK ROMAN, SIWICKI ANDRZEJ KRZYSZTOF: "Biofilm production and other virulence factors in Streptococcus spp. isolated from clinical cases of bovine mastitis in Poland", BMC VETERINARY RESEARCH, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 1 December 2017 (2017-12-01), GB , pages 398 - 7, XP093051267, ISSN: 1746-6148, DOI: 10.1186/s12917-017-1322-y
ALMEIDA RAÚL A., KERRO-DEGO OUDESSA, PRADO MARÍA E., HEADRICK SUSAN I., LEWIS MARK J., SIEBERT LYDIA J., PIGHETTI GINA M., OLIVER : "Protective effect of anti-SUAM antibodies on Streptococcus uberis mastitis", VETERINARY RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 46, no. 1, 1 December 2015 (2015-12-01), London, UK , pages 133 - 6, XP093051268, ISSN: 1297-9716, DOI: 10.1186/s13567-015-0271-3
JANG A-YEUNG, SEO HO SEONG, LIN SHUNMEI, CHUNG GOOK-HYUN, KIM HAN WOOL, LIM SANGYONG, ZHAO LEI, PARK IN HO, LIM JAE HYANG, KIM KYU: "Molecular characterization of pneumococcal surface protein K, a potential pneumococcal vaccine antigen", VIRULENCE, LANDES BIOSCIENCE, US, vol. 8, no. 6, 18 August 2017 (2017-08-18), US , pages 875 - 890, XP093051265, ISSN: 2150-5594, DOI: 10.1080/21505594.2016.1278334
J M FINCH, A W HILL, T R FIELD, J A LEIGH: "LOCAL VACCINATION WITH KILLED STREPTOCOCCUS UBERIS PROTECTS THE BOVINE MAMMARY GLAND AGAINST EXPERIMENTAL INTRAMAMMARY CHALLENGE WITH THE HOMOLOGOUS STRAIN", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 62, no. 09, 1 September 1994 (1994-09-01), US , pages 3599 - 3603, XP009052640, ISSN: 0019-9567, DOI: 10.1128/iai.62.9.3599-3603.1994
FIELD TERENCE R., WARD PHILIP N., PEDERSEN LARS H., LEIGH JAMES A.: "The Hyaluronic Acid Capsule of Streptococcus uberis Is Not Required for the Development of Infection and Clinical Mastitis", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 1, 1 January 2003 (2003-01-01), US , pages 132 - 139, XP093051266, ISSN: 0019-9567, DOI: 10.1128/IAI.71.1.132-139.2003
KACZOREK EDYTA, MAŁACZEWSKA JOANNA, WÓJCIK ROMAN, SIWICKI ANDRZEJ KRZYSZTOF: "Biofilm production and other virulence factors in Streptococcus spp. isolated from clinical cases of bovine mastitis in Poland", BMC VETERINARY RESEARCH, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 1 December 2017 (2017-12-01), GB , pages 398 - 7, XP093051267, ISSN: 1746-6148, DOI: 10.1186/s12917-017-1322-y
ALMEIDA RAÚL A., KERRO-DEGO OUDESSA, PRADO MARÍA E., HEADRICK SUSAN I., LEWIS MARK J., SIEBERT LYDIA J., PIGHETTI GINA M., OLIVER : "Protective effect of anti-SUAM antibodies on Streptococcus uberis mastitis", VETERINARY RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 46, no. 1, 1 December 2015 (2015-12-01), London, UK , pages 133 - 6, XP093051268, ISSN: 1297-9716, DOI: 10.1186/s13567-015-0271-3
Attorney, Agent or Firm:
OKUHARA Koji (JP)
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