Title:
VACCINE PREPARED UTILIZING HUMAN PARAINFLUENZA VIRUS TYPE 2 VECTOR
Document Type and Number:
WIPO Patent Application WO/2014/103310
Kind Code:
A1
Abstract:
Disclosed are: a virus vector in which a gene encoding an antigen polypeptide is integrated into a human parainfluenza virus type 2 gene, wherein the antigen polypeptide is expressed in the form of a fusion protein of the antigen polypeptide and a constituent protein of a virus; and a method for producing the virus vector. In the virus vector according to the present invention, the antigen peptide is contained on a virus particle in a quantitatively large amount. Therefore, the antigen polypeptide can be delivered to a target cell with high efficiency.
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Inventors:
FUKUMURA MASAYUKI (JP)
OHTSUKA JUNPEI (JP)
NOSAKA TETSUYA (JP)
TSURUDOME MASATO (JP)
KAWANO MITSUO (JP)
HARA KEN-ICHIRO (JP)
OHTSUKA JUNPEI (JP)
NOSAKA TETSUYA (JP)
TSURUDOME MASATO (JP)
KAWANO MITSUO (JP)
HARA KEN-ICHIRO (JP)
Application Number:
PCT/JP2013/007598
Publication Date:
July 03, 2014
Filing Date:
December 25, 2013
Export Citation:
Assignee:
BIOCOMO INC (JP)
UNIV MIE (JP)
UNIV MIE (JP)
International Classes:
C12N15/09; A61K39/145; A61P31/16; C12N7/02; C12N7/04; A61K48/00; A61P35/00
Domestic Patent References:
| WO2012108195A1 | 2012-08-16 | |||
| WO2012108195A1 | 2012-08-16 |
Foreign References:
| JP2006512904A | 2006-04-20 | |||
| JP2004329222A | 2004-11-25 | |||
| JP2006524511A | 2006-11-02 |
Other References:
VITOLOGY, vol. 377, no. 2, 2008, pages 225
VIROLOGY, vol. 362, no. 1, 2007, pages 139
VITOLOGY, vol. 16, no. 11, 2008, pages 21883
VACCINE, vol. 28, 2010, pages 2771
J VIROL., 2011, pages 6521
J VIROL., 2002, pages 1089
VACCINE, vol. 29, 2011, pages 8557
J VIROL., 2009, pages 584
VET IMMUNOL IMMUNOPATHOL., vol. 146, no. 1, 2012, pages 92
ABBAS YT., NATURE, vol. 494, no. 7435, 2013, pages 60 - 64
SAITO T. ET AL., J. EXP. MED., vol. 205, no. 7, 2008, pages 1523 - 1527
See also references of EP 2940134A4
VIROLOGY, vol. 362, no. 1, 2007, pages 139
VITOLOGY, vol. 16, no. 11, 2008, pages 21883
VACCINE, vol. 28, 2010, pages 2771
J VIROL., 2011, pages 6521
J VIROL., 2002, pages 1089
VACCINE, vol. 29, 2011, pages 8557
J VIROL., 2009, pages 584
VET IMMUNOL IMMUNOPATHOL., vol. 146, no. 1, 2012, pages 92
ABBAS YT., NATURE, vol. 494, no. 7435, 2013, pages 60 - 64
SAITO T. ET AL., J. EXP. MED., vol. 205, no. 7, 2008, pages 1523 - 1527
See also references of EP 2940134A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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