Title:
VACCINE SYSTEM FOR PREVENTING OR TREATING CANCER ON THE BASIS OF MULTIPLE CANCER CELLS AND/OR TUMOR TISSUE WHOLE CELL COMPONENTS, AND PREPARATION THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040121
Kind Code:
A1
Abstract:
A vaccine system for preventing or treating cancer on the basis of multiple cancer cells and/or tumor tissue whole cell components, and a preparation method therefor and an application thereof. A water-soluble component and a non-water-soluble component of the whole cell components mixed with a plurality of cells are delivered by using nano-scale or micron-sized particles for preparing a vaccine for preventing and treating cancer. Both the water-soluble portion and the non-water-soluble portion are loaded in a nano-vaccine or a micro-vaccine, so that a variant protein or polypeptide generated by cancer in the cell components is loaded in the nano-vaccine or the micro-vaccine. Among the whole cell components, these substances, which have immunogenicity and are produced due to illness and mutation, can be used for preventing and treating cancer. Therefore, the nano-vaccine and/or micro-vaccine system of the whole cell components of different cell sources can be used for preparing a drug for preventing and/or treating cancer.
Inventors:
LIU MI (CN)
Application Number:
PCT/CN2021/142691
Publication Date:
March 23, 2023
Filing Date:
December 29, 2021
Export Citation:
Assignee:
SUZHOU ERSHENG BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K39/00; A61K9/51; A61K39/385; A61K39/39
Domestic Patent References:
| WO2019210189A1 | 2019-10-31 | |||
| WO2016081783A1 | 2016-05-26 | |||
| WO2012146364A1 | 2012-11-01 |
Foreign References:
| CN112245574A | 2021-01-22 | |||
| US20130303960A1 | 2013-11-14 |
Other References:
YUE HUA, MA GUANGHUI: "The Development of Micro/Nano Particles and Hydrogel Based Vaccine Delivery System", MATERIALS CHINA, vol. 34, no. 3, 1 March 2015 (2015-03-01), pages 216 - 224, XP093048736, ISSN: 1674-3962, DOI: 10.7502/j.issn.1674-3962.2015.03.04
LIU LINA, WANG YUHUA, MIAO LEI, LIU QI, MUSETTI SARA, LI JUN, HUANG LEAF: "Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 26, no. 1, 1 January 2018 (2018-01-01), US , pages 45 - 55, XP093048740, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.10.020
LIU LINA, WANG YUHUA, MIAO LEI, LIU QI, MUSETTI SARA, LI JUN, HUANG LEAF: "Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 26, no. 1, 1 January 2018 (2018-01-01), US , pages 45 - 55, XP093048740, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.10.020
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
Download PDF: