Title:
VACCINE SYSTEM FOR PREVENTING OR TREATING TYPE I DIABETES AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/029027
Kind Code:
A1
Abstract:
A vaccine system for preventing or treating type I diabetes. The vaccine system utilizes delivery particles to deliver a whole-cell water-soluble component and/or non-water-soluble component in a cell or tissue containing a type I diabetes-related antigen. The immune tolerance generated by an autoantigen in a whole-cell component can be used for preventing and treating type I diabetes, and is a powerful alternative for a type I diabetes-related vaccine or drug.
Inventors:
LIU MI (CN)
Application Number:
PCT/CN2021/116632
Publication Date:
March 09, 2023
Filing Date:
September 06, 2021
Export Citation:
Assignee:
SUZHOU ERSHENG BIOMEDICAL CO LTD (CN)
International Classes:
A61K39/00; A61K9/14; A61K9/16; A61K45/06; A61K47/02; A61K47/10; A61K47/18; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/42; A61K47/46; A61P3/10
Foreign References:
| CN112245574A | 2021-01-22 | |||
| CN112114129A | 2020-12-22 | |||
| CN108853492A | 2018-11-23 |
Other References:
AU KIN MAN, MEDIK YUSRA, KE QI, TISCH ROLAND, WANG ANDREW Z.: "Immune Checkpoint‐Bioengineered Beta Cell Vaccine Reverses Early‐Onset Type 1 Diabetes", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 33, no. 25, 1 June 2021 (2021-06-01), DE , pages 2101253, XP093042993, ISSN: 0935-9648, DOI: 10.1002/adma.202101253
HAN H-S, ET AL: "A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice.", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 9, 1 January 1996 (1996-01-01), GB , pages 331 - 339, XP002153791, ISSN: 0896-8411, DOI: 10.1006/jaut.1996.0045
YAN CAIFENG, ZHANG ZHILI, HE GUOFEN: "Preventive effect of T cell inoculation on diabetes in NOD mice", JOURNAL OF SHANXI MEDICAL UNIVERSITY, CN, vol. 31, no. 4, 30 August 2000 (2000-08-30), CN , pages 308 - 309, XP009544118, ISSN: 1007-6611
HAN H-S, ET AL: "A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice.", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 9, 1 January 1996 (1996-01-01), GB , pages 331 - 339, XP002153791, ISSN: 0896-8411, DOI: 10.1006/jaut.1996.0045
YAN CAIFENG, ZHANG ZHILI, HE GUOFEN: "Preventive effect of T cell inoculation on diabetes in NOD mice", JOURNAL OF SHANXI MEDICAL UNIVERSITY, CN, vol. 31, no. 4, 30 August 2000 (2000-08-30), CN , pages 308 - 309, XP009544118, ISSN: 1007-6611
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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