Title:
VACCINE
Document Type and Number:
WIPO Patent Application WO2000068259
Kind Code:
A3
Abstract:
Use of a polypeptide which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes, or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating a protective immune response to S. pyogenes, in the manufacture of medicament for use as a vaccine against S. pyogenes. A pharmaceutical composition for use in vaccinating against S. pyogenes or Group B streptococcus comprises a polypeptide which comprises: (A) the amino acid sequence of SEQ ID No 2, (B) a variant of (A) which is capable of conferring protective immunity to S. pyogenes or Group B streptococcus, or (C) a fragment of (A) or (B) of at least 6 amino acids in length which is capable of conferring protective immunity to S. pyogenes or Group B streptococcus.
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Inventors:
LINDAHL GUNNAR (SE)
STALHAMMAR-CARLEMALM MARGARETH (SE)
ARESCHOUG THOMAS (SE)
LARSSON CHARLOTTE (SE)
STALHAMMAR-CARLEMALM MARGARETH (SE)
ARESCHOUG THOMAS (SE)
LARSSON CHARLOTTE (SE)
Application Number:
PCT/IB2000/000726
Publication Date:
July 12, 2001
Filing Date:
May 05, 2000
Export Citation:
Assignee:
LINDAHL GUNNAR (SE)
STALHAMMAR CARLEMALM MARGARETH (SE)
ARESCHOUG THOMAS (SE)
LARSSON CHARLOTTE (SE)
STALHAMMAR CARLEMALM MARGARETH (SE)
ARESCHOUG THOMAS (SE)
LARSSON CHARLOTTE (SE)
International Classes:
C07K14/315; A61K39/00; (IPC1-7): C07K14/315; C12N15/00; A61K39/09
Domestic Patent References:
| WO1994010317A2 | 1994-05-11 | |||
| WO1998006428A1 | 1998-02-19 |
Foreign References:
| EP0866133A2 | 1998-09-23 |
Other References:
J D CHAPPELL ET AL: "Demonstration of protection in mice from a lethal challenge of three M serotypes of Streptococcus pyogenes using an M-negative vaccine", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 11, 1993, pages 643 - 649, XP002137199, ISSN: 0264-410X
WÄSTFELT MARIA ET AL: "Identification of a family of streptococcal surface proteins with extremely repetitive structure.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 31, 1996, pages 18892 - 18897, XP002152237, ISSN: 0021-9258
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells.", MOLECULAR MICROBIOLOGY, vol. 33, no. 1, July 1999 (1999-07-01), pages 208 - 219, XP000964694, ISSN: 0950-382X
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "Cross-protection between group A and group B streptococci due to cross-reacting surface proteins.", JOURNAL OF INFECTIOUS DISEASES, vol. 182, no. 1, July 2000 (2000-07-01), pages 142 - 149, XP002156997, ISSN: 0022-1899
LACHENAUER C S ET AL: "Mosaicism in the alpha-like protein genes of group B streptococci.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 17, 15 August 2000 (2000-08-15), August 15, 2000, pages 9630 - 9635, XP002152238, ISSN: 0027-8424
WÄSTFELT MARIA ET AL: "Identification of a family of streptococcal surface proteins with extremely repetitive structure.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 31, 1996, pages 18892 - 18897, XP002152237, ISSN: 0021-9258
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells.", MOLECULAR MICROBIOLOGY, vol. 33, no. 1, July 1999 (1999-07-01), pages 208 - 219, XP000964694, ISSN: 0950-382X
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "Cross-protection between group A and group B streptococci due to cross-reacting surface proteins.", JOURNAL OF INFECTIOUS DISEASES, vol. 182, no. 1, July 2000 (2000-07-01), pages 142 - 149, XP002156997, ISSN: 0022-1899
LACHENAUER C S ET AL: "Mosaicism in the alpha-like protein genes of group B streptococci.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 17, 15 August 2000 (2000-08-15), August 15, 2000, pages 9630 - 9635, XP002152238, ISSN: 0027-8424
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