Title:
VACCINES AGAINST PREGNANCY-ASSOCIATED MALARIA
Document Type and Number:
WIPO Patent Application WO/2012/014073
Kind Code:
A3
Abstract:
The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.
Inventors:
TUIKUE NDAM NICAISE (FR)
DELORON PHILIPPE (FR)
GNIDEHOU SEDAMI URSULA ALIX CARINE (FR)
QUIVIGER MICKAEL (FR)
BIGEY PASCAL (FR)
SCHERMAN DANIEL (FR)
DELORON PHILIPPE (FR)
GNIDEHOU SEDAMI URSULA ALIX CARINE (FR)
QUIVIGER MICKAEL (FR)
BIGEY PASCAL (FR)
SCHERMAN DANIEL (FR)
Application Number:
PCT/IB2011/002069
Publication Date:
April 26, 2012
Filing Date:
July 29, 2011
Export Citation:
Assignee:
INST RECH DEVELOPPEMENT IRD (FR)
TUIKUE NDAM NICAISE (FR)
DELORON PHILIPPE (FR)
GNIDEHOU SEDAMI URSULA ALIX CARINE (FR)
QUIVIGER MICKAEL (FR)
BIGEY PASCAL (FR)
SCHERMAN DANIEL (FR)
TUIKUE NDAM NICAISE (FR)
DELORON PHILIPPE (FR)
GNIDEHOU SEDAMI URSULA ALIX CARINE (FR)
QUIVIGER MICKAEL (FR)
BIGEY PASCAL (FR)
SCHERMAN DANIEL (FR)
International Classes:
A61K48/00; A61K39/015; A61P33/06; C07K14/445
Domestic Patent References:
| WO2004067559A1 | 2004-08-12 |
Other References:
NIELSEN MORTEN A ET AL: "Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.", INFECTION AND IMMUNITY, vol. 77, no. 6, June 2009 (2009-06-01), pages 2482 - 2487, XP002636115, ISSN: 1098-5522
KHUNRAE P ET AL: "Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 397, no. 3, 2 April 2010 (2010-04-02), pages 826 - 834, XP026954293, ISSN: 0022-2836, [retrieved on 20100125]
HILL ADRIAN V S ET AL: "Prime-boost vectored malaria vaccines: progress and prospects.", HUMAN VACCINES, vol. 6, no. 1, January 2010 (2010-01-01), pages 78 - 83, XP002636116, ISSN: 1554-8619
AVRIL MARION ET AL: "Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA", INFECTION AND IMMUNITY, vol. 76, no. 4, April 2008 (2008-04-01), pages 1791 - 1800, XP002636117, ISSN: 0019-9567
SALANTI ALI ET AL: "Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies", MALARIA JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 11 January 2010 (2010-01-11), pages 11, XP021067752, ISSN: 1475-2875
DAHLBACK M ET AL: "Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?", TRENDS IN PARASITOLOGY, vol. 26, no. 5, 1 May 2010 (2010-05-01), ELSEVIER CURRENT TRENDS, GB, pages 230 - 235, XP027030428, ISSN: 1471-4922, [retrieved on 20100226]
SRIVASTAVA ANAND ET AL: "Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region", PLOS ONE, vol. 6, no. 5, May 2011 (2011-05-01), XP002669766, ISSN: 1932-6203
PINTO VERA V ET AL: "Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA.", PLOS ONE, vol. 6, no. 3, E17942, March 2011 (2011-03-01), pages 1 - 8, XP002636118, ISSN: 1932-6203
DAHLBÄCK MADELEINE ET AL: "The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 6 MAY 2011 LNKD- PUBMED:21398524, vol. 286, no. 18, 6 May 2011 (2011-05-06), pages 15908 - 15917, XP002669767, ISSN: 1083-351X
BITA BORDBAR ET AL: "Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies", VACCINE, vol. 30, no. 7, 1 February 2012 (2012-02-01), pages 1343 - 1348, XP055019210, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2011.12.065
BIGEY PASCAL ET AL: "The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A", THE JOURNAL OF INFECTIOUS DISEASES UNITED STATES 15 DEC 2010,, vol. 204, no. 7, 1 October 2011 (2011-10-01), pages 1125 - 1133, XP009156487, ISSN: 1537-6613
KHUNRAE P ET AL: "Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 397, no. 3, 2 April 2010 (2010-04-02), pages 826 - 834, XP026954293, ISSN: 0022-2836, [retrieved on 20100125]
HILL ADRIAN V S ET AL: "Prime-boost vectored malaria vaccines: progress and prospects.", HUMAN VACCINES, vol. 6, no. 1, January 2010 (2010-01-01), pages 78 - 83, XP002636116, ISSN: 1554-8619
AVRIL MARION ET AL: "Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA", INFECTION AND IMMUNITY, vol. 76, no. 4, April 2008 (2008-04-01), pages 1791 - 1800, XP002636117, ISSN: 0019-9567
SALANTI ALI ET AL: "Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies", MALARIA JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 11 January 2010 (2010-01-11), pages 11, XP021067752, ISSN: 1475-2875
DAHLBACK M ET AL: "Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?", TRENDS IN PARASITOLOGY, vol. 26, no. 5, 1 May 2010 (2010-05-01), ELSEVIER CURRENT TRENDS, GB, pages 230 - 235, XP027030428, ISSN: 1471-4922, [retrieved on 20100226]
SRIVASTAVA ANAND ET AL: "Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region", PLOS ONE, vol. 6, no. 5, May 2011 (2011-05-01), XP002669766, ISSN: 1932-6203
PINTO VERA V ET AL: "Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA.", PLOS ONE, vol. 6, no. 3, E17942, March 2011 (2011-03-01), pages 1 - 8, XP002636118, ISSN: 1932-6203
DAHLBÄCK MADELEINE ET AL: "The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 6 MAY 2011 LNKD- PUBMED:21398524, vol. 286, no. 18, 6 May 2011 (2011-05-06), pages 15908 - 15917, XP002669767, ISSN: 1083-351X
BITA BORDBAR ET AL: "Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies", VACCINE, vol. 30, no. 7, 1 February 2012 (2012-02-01), pages 1343 - 1348, XP055019210, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2011.12.065
BIGEY PASCAL ET AL: "The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A", THE JOURNAL OF INFECTIOUS DISEASES UNITED STATES 15 DEC 2010,, vol. 204, no. 7, 1 October 2011 (2011-10-01), pages 1125 - 1133, XP009156487, ISSN: 1537-6613
Attorney, Agent or Firm:
TOUATI, Catherine et al. (52 rue de la Victoire, Paris Cedex 09, FR)
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