Title:
VANCOMYCIN ANALOGS
Document Type and Number:
WIPO Patent Application WO2001081372
Kind Code:
A3
Abstract:
Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the glucose residue attached to the amino acid four of the vancomycin heptapeptide chain are disclosed. Methods of making the compounds and methods of using the compounds to treat a bacterial infection in a host are also disclosed.
Inventors:
KAHNE DANIEL
WALKER SUZANNE
WALKER SUZANNE
Application Number:
PCT/US2001/011040
Publication Date:
May 16, 2002
Filing Date:
April 05, 2001
Export Citation:
Assignee:
UNIV PRINCETON (US)
International Classes:
A61P31/04; C07K9/00; A61K38/00; (IPC1-7): C07K9/00; A61K38/14; A61P31/04
Domestic Patent References:
| WO2000039156A1 | 2000-07-06 | |||
| WO2001057071A2 | 2001-08-09 | |||
| WO2000004044A1 | 2000-01-27 | |||
| WO2000069893A1 | 2000-11-23 | |||
| WO2000069892A1 | 2000-11-23 |
Foreign References:
| EP0301785A2 | 1989-02-01 |
Other References:
SUNDRAM UMA N ET AL: "General and Efficient Method for the Solution- and Solid-Phase Synthesis of Vancomycin Carboxamide Derivatives", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, 10 March 1995 (1995-03-10), pages 1102 - 1103, XP002183429, ISSN: 0022-3263
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