Title:
VARIANT ADENO-ASSOCIATED VIRUS AND APPLICATION THEREOF IN DISEASE TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/143366
Kind Code:
A1
Abstract:
A variant adeno-associated virus and the use thereof in gene treatment and cell regeneration of a mediated cochlea. The variant adeno-associated virus can efficiently transduce hair cells and/or support cells in the cochlea, promotes regeneration of HC-like cells, and helps restoring hearing. The variant adeno-associated virus is used as a safe vector, and has great clinical potential in treating a hearing impairment disease caused by cochlear injury, and especially in treating hearing loss caused by hair cell death.
Inventors:
ZHONG GUISHENG (CN)
CHU CENFENG (CN)
CHU CENFENG (CN)
Application Number:
PCT/CN2023/073135
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
SHANGHAI EMAYGENE TECH CO LTD (CN)
International Classes:
A61K48/00; C07K14/015; A61P27/16; C12N7/01; C12N15/35
Domestic Patent References:
| WO2016134338A1 | 2016-08-25 |
Foreign References:
| CN110437317A | 2019-11-12 | |||
| CN104487579A | 2015-04-01 | |||
| US20130310443A1 | 2013-11-21 | |||
| US20210355171A1 | 2021-11-18 | |||
| CN108699565A | 2018-10-23 | |||
| CN111349148A | 2020-06-30 | |||
| CN112424359A | 2021-02-26 |
Other References:
TAO YONG, LIU XIAOYI, YANG LIU, CHU CENFENG, TAN FANGZHI, YU ZEHUA, KE JUNZI, LI XIANG, ZHENG XIAOFEI, ZHAO XINGLE, QI JIEYU, LIN : "AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 7, no. 1, 22 April 2022 (2022-04-22), pages 109, XP093080434, DOI: 10.1038/s41392-022-00938-8
TAN FANGZHI, CHU CENFENG, QI JIEYU, LI WENYAN, YOU DAN, LI KE, CHEN XIN, ZHAO WEIDONG, CHENG CHENG, LIU XIAOYI, QIAO YUNBO, SU BIN: "AAV-ie enables safe and efficient gene transfer to inner ear cells", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055800264, DOI: 10.1038/s41467-019-11687-8
TAN FANGZHI, CHU CENFENG, QI JIEYU, LI WENYAN, YOU DAN, LI KE, CHEN XIN, ZHAO WEIDONG, CHENG CHENG, LIU XIAOYI, QIAO YUNBO, SU BIN: "AAV-ie enables safe and efficient gene transfer to inner ear cells", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055800264, DOI: 10.1038/s41467-019-11687-8
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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