VASCULAR EMBOLUS OF PACLITAXEL-SODIUM ALGINATE MICROSPHERE AND ITS PREPARATION

Title:

VASCULAR EMBOLUS OF PACLITAXEL-SODIUM ALGINATE MICROSPHERE AND ITS PREPARATION

Document Type and Number:

WIPO Patent Application WO/2006/029554

Kind Code:

A1

Abstract:

Vascular embolus of Paclitaxel-sodium alginate microsphere and its preparation A sodium alginate microsphere vascular embolus containing paclitaxel. The preparation of it consists of the following steps: preparing the solution of paclitaxel, sodium alginate and dilvalent metal cations such as BaCl₂ etc. by order;mixing the palitaxle solution and sodium alginate solution,and then mixing them with the curing solution of BaCl₂ or CaC1₂ and the like. Then the obtained is the paclitaxel-containing sodium alginate microsphere vascular embolus. The carrier materials of the vascular embolus according to the invention are natural extracts and have good biocompatibility and are biodegradable; the side effect of the pharmaceutic loaded by them is minimal, and it is therefore suitable for the vascular embolism and chemotherapy against the tumor.

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Inventors:

LI XINJIAN (CN)
HONG HONG (CN)

Application Number:

PCT/CN2005/000320

Publication Date:

March 23, 2006

Filing Date:

March 16, 2005

Export Citation:

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Assignee:

BEIJING HONGYIYAO SCIENCE & TE (CN)
LI XINJIAN (CN)
HONG HONG (CN)

International Classes:

A61K9/00; A61K9/02; A61K31/337; A61K47/36; A61M31/00; A61P35/00; (IPC1-7): A61K9/50; A61K31/337; A61P35/00

Domestic Patent References:

WO2003007914A2	2003-01-30
WO2003020210A2	2003-03-13

Foreign References:

CN1399958A

2003-03-05

Other References:

DAI Z. ET AL: "Studies on cetyl-chitosan nanosphere as carriers for paclitaxel", CHINESE TRADITIONAL AND HERBAL DRUGS, vol. 34, no. 2, February 2003 (2003-02-01), pages 20 - 122, XP008112837
XIONG X. ET AL: "Preliminary study on preparation of paclitaxel microsphere", CHINES JOURNAL OF NEW DRUGS, vol. 10, no. 7, 2001, pages 517 - 519, XP008138004
See also references of EP 1797874A4

Attorney, Agent or Firm:

BEIJING BEIXIN-ZHICHENG INTELLECTUAL PROPERTY AGENT CO., LTD. (Xizhimen Nandajie Xicheng District, Beijing 5, CN)

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