Title:
VASCULAR ENDOTHELIAL CELL GROWTH FACTOR ANTAGONISTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2000037502
Kind Code:
A3
Abstract:
The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF antibodies and VEGF receptor fusion proteins. Methods of treating edema and stroke using VEGF antagonists are also provided.
Inventors:
VAN BRUGGEN NICHOLAS
FERRARA NAPOLEONE
FERRARA NAPOLEONE
Application Number:
PCT/US1999/029475
Publication Date:
November 23, 2000
Filing Date:
December 09, 1999
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
A61K38/00; A61K39/395; A61K45/00; A61P3/10; A61P7/10; C12N15/09; A61P9/10; A61P11/00; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P43/00; C07K14/71; C07K16/22; C07K16/24; C12N9/96; (IPC1-7): A61K39/395; A61K38/17; A61P7/10; C07K19/00
Domestic Patent References:
| WO1994010202A1 | 1994-05-11 | |||
| WO1998016551A2 | 1998-04-23 | |||
| WO1998045331A2 | 1998-10-15 | |||
| WO1997044453A1 | 1997-11-27 |
Other References:
BERKMAN, RICHARD A. ET AL: "Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.", JOURNAL OF CLINICAL INVESTIGATION, (1993) VOL. 91, NO. 1, PP. 153-159., XP000909359
VAN BRUGGEN N ET AL: "VEGF antagonism reduces edema formation and tissue damage after ischemia /reperfusion injury in the mouse brain.", JOURNAL OF CLINICAL INVESTIGATION, (1999 DEC) 104 (11) 1613-20., XP000909358
VAN BRUGGEN N ET AL: "VEGF antagonism reduces edema formation and tissue damage after ischemia /reperfusion injury in the mouse brain.", JOURNAL OF CLINICAL INVESTIGATION, (1999 DEC) 104 (11) 1613-20., XP000909358
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