VASCULAR REGENERATION PROMOTERS

WIPO Patent Application WO/2002/067950

A1

Efficacious intravenous preparations, skin preparations for external use or medicinal compositions comprising ginsenoside derivatives (in particular, dihydroginsenoside Rb¿1?) which are useful in promoting vascular regeneration and reconstruction or preventing, treating and remedying diseases or pathological conditions causing blood flow failures, and ginsenosides (in particular dihydroginsenoside Rb¿1?) which are useful in preventing, treating and remedying diseases or pathological conditions causing blood flow failures via the activation of a transcription factor STAT5 and/or a transcription factor HIF-1 are provided. Namely, intravenous preparations, skin preparations for external use or medicinal compositions comprising ginsenoside derivatives (in particular, dihydroginsenoside Rb¿1?) which are particularly useful in promoting vascular regeneration and reconstruction or preventing, treating and remedying diseases or pathological conditions causing blood flow failures. Medicinal compositions comprising ginsenosides such as dihydroginsenoside Rb¿1? which are particularly useful in preventing, treating and remedying diseases or pathological conditions causing blood flow failures via the activation of a transcription factor STAT5 and/or a transcription factor HIF-1 are provided.

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SAKANAKA MASAHIRO (JP)
HASHIMOTO KOJI (JP)
TANAKA JUNYA (JP)
HATA RYUJI (JP)
UNO HIDEMITSU (JP)
KURAMOTO MAKOTO (JP)
MITSUTA NORIAKI (JP)

PCT/JP2002/000368

September 06, 2002

January 21, 2002

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JAPAN SCIENCE & TECH CORP (JP)
SAKANAKA MASAHIRO (JP)
HASHIMOTO KOJI (JP)
TANAKA JUNYA (JP)
HATA RYUJI (JP)
UNO HIDEMITSU (JP)
KURAMOTO MAKOTO (JP)
MITSUTA NORIAKI (JP)

A61K31/704; A61P1/16; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P13/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/18; A61P37/02; A61P43/00; C07J9/00; (IPC1-7): A61K31/704; A61K45/00; A61P9/10; A61P17/02; A61P25/00; A61P43/00; G01N33/15; G01N33/50

WO2001092289A1	2001-12-06
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WO2000048608A1	2000-08-24
WO2000037481A1	2000-06-29
WO1997018824A1	1997-05-29
WO1996024604A1	1996-08-15
WO1996028114A1	1996-09-19
WO1997008174A1	1997-03-06

JPH1036388A	1998-02-10
JPS5948421A	1984-03-19
JPS59227823A	1984-12-21
US5589182A	1996-12-31
US4708949A	1987-11-24

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Saeki, Norio (Taka-ai Building 15-2, Nihonbashi 3-chom, Chuo-ku Tokyo, JP)

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