Title:
VECTOR COMPRISING POLYMER MODIFIED SIRNA LIPOSOMES
Document Type and Number:
WIPO Patent Application WO2006016097
Kind Code:
A3
Abstract:
The present invention relates to a non-viral delivery vector comprising a liposome, wherein one or more lipids of the liposome are coupled, reversibly or irreversibly, to one or more polymers, and wherein the liposome comprises siRNA.
Inventors:
KELLER MICHAEL (CH)
JORGENSEN MICHAEL (ZA)
MILLER ANDREW DAVID (GB)
PEROUZEL ERIC (FR)
JORGENSEN MICHAEL (ZA)
MILLER ANDREW DAVID (GB)
PEROUZEL ERIC (FR)
Application Number:
PCT/GB2005/002634
Publication Date:
November 23, 2006
Filing Date:
July 06, 2005
Export Citation:
Assignee:
IC VEC LTD (GB)
KELLER MICHAEL (CH)
JORGENSEN MICHAEL (ZA)
MILLER ANDREW DAVID (GB)
PEROUZEL ERIC (FR)
KELLER MICHAEL (CH)
JORGENSEN MICHAEL (ZA)
MILLER ANDREW DAVID (GB)
PEROUZEL ERIC (FR)
International Classes:
A61K48/00; A61K9/127; C12N15/88
Domestic Patent References:
| WO2005007196A2 | 2005-01-27 | |||
| WO2005121348A1 | 2005-12-22 | |||
| WO2005026372A1 | 2005-03-24 | |||
| WO2005000272A1 | 2005-01-06 |
Foreign References:
| US20040018176A1 | 2004-01-29 | |||
| US6756054B1 | 2004-06-29 | |||
| US6403056B1 | 2002-06-11 |
Other References:
COOPER R G ET AL: "POLYAMINE ANALOGUES OF 3BETA-UN-(N',N'-DIMETHYLAMINOETHANE)CARBAMOYL- CHOLESTEROL (DC-CHOL) AS AGENTS FOR GENE DELIVERY", CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US, vol. 4, no. 1, January 1998 (1998-01-01), pages 137 - 151, XP000729238, ISSN: 0947-6539
FLEINER MICHAEL ET AL: "Studies on protein-liposome coupling using novel thiol-reactive coupling lipids: Influence of spacer length and polarity", BIOCONJUGATE CHEMISTRY, vol. 12, no. 4, July 2001 (2001-07-01), pages 470 - 475, XP002391559, ISSN: 1043-1802
CHEN TAO ET AL: "Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 11, no. 3, March 2000 (2000-03-01), pages 433 - 437, XP002157295, ISSN: 1043-1802
FLEINER MICHAEL ET AL: "Studies on protein-liposome coupling using novel thiol-reactive coupling lipids: Influence of spacer length and polarity", BIOCONJUGATE CHEMISTRY, vol. 12, no. 4, July 2001 (2001-07-01), pages 470 - 475, XP002391559, ISSN: 1043-1802
CHEN TAO ET AL: "Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 11, no. 3, March 2000 (2000-03-01), pages 433 - 437, XP002157295, ISSN: 1043-1802
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