Title:
VIRAL INTERFERON ANTAGONISTS AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO2004033705
Kind Code:
A3
Abstract:
The present invention relates to compositions comprising one or more viral interferon antagonists and methods of utilizing said compositions to modulate the cellular interferon immune response. In particular, the present invention relates to pharmaceutical compositions comprising one or more viral interferon antagonists and methods of utilizing said compositions to prevent, treat or ameliorate an immune disorder characterized by aberrant interferon expression and/or activity. The invention also relates to methods of treating, preventing or ameliorating the symptoms of an inflammatory disorder comprising administering to a subject in need thereof one or more viral interferon antagonist. The present invention also relates to compositions comprising fusion proteins comprising one or more viral interferon antagonists and a heterologous polypeptide, and methods of using said compositions to modulate the cellular interferon immune response. The present invention further relates to articles of manufacture comprising one or more viral interferon antagonists or fusion proteins.
Inventors:
PALESE PETER (US)
GARCIA-SASTRE ADOLOFO (US)
GARCIA-SASTRE ADOLOFO (US)
Application Number:
PCT/US2002/032656
Publication Date:
November 04, 2004
Filing Date:
October 10, 2002
Export Citation:
Assignee:
SINAI SCHOOL MEDICINE (US)
PALESE PETER (US)
GARCIA-SASTRE ADOLOFO (US)
PALESE PETER (US)
GARCIA-SASTRE ADOLOFO (US)
International Classes:
A61K39/12; A61K39/145; A61K39/155; C12P21/08; (IPC1-7): A61K39/12; A61K39/00; A61K39/38; A61K38/21; A61K45/00; A61K47/00; C12N1/00; C07K1/00; C07K14/00; C07K17/00; C12P21/08
Other References:
BASLER C.F. ET AL: "The Ebola virus VP35 protein functions as a type I IFN antagonist", PNAS, vol. 98, no. 22, October 2000 (2000-10-01), pages 12289 - 12298, XP002979984
WANG X. ET AL: "Influenza A Virus Ns1 Protein Prevents Activation Of Nf-Kappab And Induction Of Alpha/Beta Interferon", JOURNAL OF VIROLOGY, vol. 74, no. 24, December 2000 (2000-12-01), pages 11566 - 11573, XP001181389
SCHLENDER J. ET AL: "BOVINE RESPIRATORY SYNCYTIAL VIRUS NONSTRUCTURAL PROTEINS NS1 AND NS2 COOPERATIVELY ANTAGONIZE ALPHA/BETA INTERFERON-INDUCED ANTIVIRAL RESPONSE", JOURNAL OF VIROLOGY, vol. 74, no. 18, September 2000 (2000-09-01), pages 8234 - 8242, XP000972437
WANG X. ET AL: "Influenza A Virus Ns1 Protein Prevents Activation Of Nf-Kappab And Induction Of Alpha/Beta Interferon", JOURNAL OF VIROLOGY, vol. 74, no. 24, December 2000 (2000-12-01), pages 11566 - 11573, XP001181389
SCHLENDER J. ET AL: "BOVINE RESPIRATORY SYNCYTIAL VIRUS NONSTRUCTURAL PROTEINS NS1 AND NS2 COOPERATIVELY ANTAGONIZE ALPHA/BETA INTERFERON-INDUCED ANTIVIRAL RESPONSE", JOURNAL OF VIROLOGY, vol. 74, no. 18, September 2000 (2000-09-01), pages 8234 - 8242, XP000972437
Download PDF:
Previous Patent: NOVEL K99−5278 SUBSTANCES AND PROCESS FOR PRODUCING THE SAME
Next Patent: NUCLEIC ACIDS ENCODING DURAMYCIN
Next Patent: NUCLEIC ACIDS ENCODING DURAMYCIN