Title:
VIRAL VECTOR PRODUCIBILITY ENHANCER AND METHOD FOR PRODUCING VIRAL VECTOR
Document Type and Number:
WIPO Patent Application WO/2023/157976
Kind Code:
A1
Abstract:
To improve the producibility of a viral vector in production of the viral vector using virus-vector-producing cells. A protein involved in the DNA damage response is inhibited in cells that produce the viral vector.
Inventors:
MIYAGAWA YOSHITAKA (JP)
OKADA TAKASHI (JP)
UCHIKAI TAKAO (JP)
OKADA TAKASHI (JP)
UCHIKAI TAKAO (JP)
Application Number:
PCT/JP2023/006197
Publication Date:
August 24, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
NIPPON MEDICAL SCHOOL FOUNDATION (JP)
International Classes:
C12N5/07; C12N7/01
Foreign References:
| JP2016504913A | 2016-02-18 |
Other References:
YANG SONGBAI; ZHU JINGJING; ZHOU XIAOLONG; WANG HAN; LI XIANGCHEN; ZHAO AYONG: "Induction of the unfolded protein response (UPR) during pseudorabies virus infection", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 239, 31 October 2019 (2019-10-31), NL , XP085920142, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2019.108485
PéREZ-OLAIS J. HUMBERTO; RUIZ-JIMéNEZ FERNANDO; CALDERóN-GARCIA ESTHER J.; DE JESúS-GONZáLEZ L. ADRIá: "The activity of Aurora kinase B is required for dengue virus release", VIRUS RESEARCH, AMSTERDAM, NL, vol. 274, 15 October 2019 (2019-10-15), NL , XP085882739, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2019.197777
PéREZ-OLAIS J. HUMBERTO; RUIZ-JIMéNEZ FERNANDO; CALDERóN-GARCIA ESTHER J.; DE JESúS-GONZáLEZ L. ADRIá: "The activity of Aurora kinase B is required for dengue virus release", VIRUS RESEARCH, AMSTERDAM, NL, vol. 274, 15 October 2019 (2019-10-15), NL , XP085882739, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2019.197777
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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