Title:
VIRUS-LIKE PARTICLE COMBINATION VACCINE COMPRISING INFLUENZA A VIRUS ANTIGEN PROTEIN HA, NA OR M2E5X
Document Type and Number:
WIPO Patent Application WO/2024/080637
Kind Code:
A1
Abstract:
The present invention relates to a virus-like particle combination vaccine comprising influenza A virus antigen protein HA, NA or M2e5x. A recombinant universal influenza-virus-like particle vaccine for protection against infection by influenza A virus (H1N1, H3N2 and H5N1) and influenza B virus (B/Victoria lineages) has been developed by preparing a virus-like particle vaccine expressed by a combination of: hemagglutinin (HA) and neuraminidase (NA) antigen proteins of 2020/2021 influenza viruses of A/Guangdong-Maonan/SWL1536/2019 (H1N1) and A/Hong Kong/2671/2019 (H3N2), which were recently predicted by the World Health Organization (WHO); and heterologous tandem M2e repeat (M2e5x) antigen proteins of conventional human, swine, and avian influenza viruses. The virus-like particle vaccine having high efficacy against various influenza, obtained by developing, on the basis of the present invention, a vaccine exhibiting high immunogenicity, can reduce infection and mortality caused by influenza A and B viruses during a global pandemic.
Inventors:
JEON BOK SIL (KR)
YOON KEON WOONG (KR)
YOON KEON WOONG (KR)
Application Number:
PCT/KR2023/014922
Publication Date:
April 18, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
C12N7/00; A61K39/145; A61P31/16; C07K14/005
Foreign References:
| KR20150027882A | 2015-03-13 | |||
| KR20210110940A | 2021-09-10 |
Other References:
KIM KI-HYE, LI ZHUO, BHATNAGAR NOOPUR, SUBBIAH JEEVA, PARK BO RYOUNG, SHIN CHONG HYUN, PUSHKO PETER, WANG BAO-ZHONG, KANG SANG-MOO: "Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle", PLOS PATHOGENS, PUBLIC LIBRARY OF SCIENCE, US, vol. 18, no. 8, 25 August 2022 (2022-08-25), US , pages e1010755, XP093116242, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1010755
FARHAD REZAEI: "Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses", IRANIAN RED CRESCENT MEDICAL JOURNAL, vol. 15, no. 1, 1 January 2013 (2013-01-01), pages 75 - 82, XP093157552, ISSN: 2074-1804, DOI: 10.5812/ircmj.6252
ASGHAR ABDOLI: "An H1-H3 chimeric influenza virosome confers complete protection against lethal challenge with PR8 (H1N1) and X47 (H3N2) viruses in mice", PATHOGENS AND DISEASE, OXFORD UNIVERSITY PRESS, GB, vol. 72, no. 3, 1 September 2014 (2014-09-01), GB , pages 197 - 207, XP093157553, ISSN: 2049-632X, DOI: 10.1111/2049-632X.12206
FARHAD REZAEI: "Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses", IRANIAN RED CRESCENT MEDICAL JOURNAL, vol. 15, no. 1, 1 January 2013 (2013-01-01), pages 75 - 82, XP093157552, ISSN: 2074-1804, DOI: 10.5812/ircmj.6252
ASGHAR ABDOLI: "An H1-H3 chimeric influenza virosome confers complete protection against lethal challenge with PR8 (H1N1) and X47 (H3N2) viruses in mice", PATHOGENS AND DISEASE, OXFORD UNIVERSITY PRESS, GB, vol. 72, no. 3, 1 September 2014 (2014-09-01), GB , pages 197 - 207, XP093157553, ISSN: 2049-632X, DOI: 10.1111/2049-632X.12206
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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