Title:
VIRUS MAIN PROTEASE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE
Document Type and Number:
WIPO Patent Application WO/2023/283831
Kind Code:
A1
Abstract:
Disclosed in the present invention is a compound having an inhibitory effect on a virus main protease (3CL protease, Mpro), which also has a significant inhibitory activity on the Mpros of SARS coronavirus (SARS-CoV) and novel coronavirus (SARS-Cov-2). Further disclosed in the present invention is an application of a pharmaceutical composition containing such a compound or a pharmaceutically acceptable salt of the pharmaceutical composition in the preparation, prevention and/or treatment of virus Mpro-associated diseases, for example, in the treatment of novel coronavirus (SARS-Cov-2)-associated diseases.
Inventors:
SHEN ZUYUAN (CN)
LI YUE (CN)
ZHU JIAN (CN)
HUANG QINQIN (CN)
YIN JIAN (CN)
XU YANFEN (CN)
WU ALIANG (CN)
SU WENJI (CN)
KUAI LETIAN (CN)
LI YUE (CN)
ZHU JIAN (CN)
HUANG QINQIN (CN)
YIN JIAN (CN)
XU YANFEN (CN)
WU ALIANG (CN)
SU WENJI (CN)
KUAI LETIAN (CN)
Application Number:
PCT/CN2021/106302
Publication Date:
January 19, 2023
Filing Date:
July 14, 2021
Export Citation:
Assignee:
WUXI APPTEC SHANGHAI CO LTD (CN)
International Classes:
A61K31/165; C07D231/56; A61K31/277; A61K31/416; A61K31/44; A61K31/4439; A61P31/14; C07C231/12; C07C235/06; C07C253/30; C07C255/57; C07D213/81; C07D401/04
Foreign References:
| US20050267071A1 | 2005-12-01 | |||
| TW200424175A | 2004-11-16 | |||
| CN106928206A | 2017-07-07 | |||
| CN105837487A | 2016-08-10 | |||
| CN103159665A | 2013-06-19 |
Attorney, Agent or Firm:
ANJIE LAW FIRM (CN)
Download PDF: