Title:
VISIBLE LIGHT-CURABLE WATER-SOLUBLE CHITOSAN DERIVATIVE, CHITOSAN HYDROGEL, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/030631
Kind Code:
A1
Abstract:
The present invention relates to a visible light-curable water-soluble chitosan derivative, a hydrogel, and a preparation method therefor and, more specifically, to a visible light-curable glycol chitosan derivative which is cured by light in the visible light range and has wound healing ability, a hydrogel, and a preparation method therefor. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative according to the present invention using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.
Inventors:
YANG DAE HYEOK (KR)
CHUN HEUNG JAE (KR)
SEO DONG IN (KR)
CHUN HEUNG JAE (KR)
SEO DONG IN (KR)
Application Number:
PCT/KR2017/006393
Publication Date:
February 15, 2018
Filing Date:
June 19, 2017
Export Citation:
Assignee:
THE CATHOLIC UNIV OF KOREA INDUSTRY ACADEMY COOPERATION (KR)
International Classes:
C08B37/08; A61K9/06; A61K31/722; A61K47/36; A61L26/00; C08J3/075; C08J3/24; C08J3/28
Foreign References:
| KR20120022383A | 2012-03-12 |
Other References:
AMSDEN, BRIAN G. ET AL.: "Methacrylated Glycol Chitosan as a Photopolymerizable Biomaterial", BIOMACROMOLECULES, vol. 8, no. 12, 22 November 2007 (2007-11-22), pages 3758 - 3766, XP055126113
CHEN, SZU-HSIEN ET AL.: "Assessment of Reinforced Poly(ethylene glycol) Chitosan Hydrogels as Dressings in a Mouse Skin Wound Defect Model", MATERIALS SCIENCE AND ENGINEERING C, vol. 33, 24 February 2013 (2013-02-24), pages 2584 - 2594, XP028584692
ARAKAWA, CHRISTOPHER KENJI: "A Novel Photopolymerizable Chitosan Collagen Hydrogel for Bone Tissue Engineering", BIOMEDICAL ENGINEERING, 2012, pages i - x and 1-83, XP055462859
HU , JUNLI ET AL.: "Visible Light Crosslinkable Chitosan Hydrogels for Tissue Engineering", ACTA BIOMATERIALIA, vol. 8, 30 January 2012 (2012-01-30), pages 1730 - 1738, XP028476145
CHEN, SZU-HSIEN ET AL.: "Assessment of Reinforced Poly(ethylene glycol) Chitosan Hydrogels as Dressings in a Mouse Skin Wound Defect Model", MATERIALS SCIENCE AND ENGINEERING C, vol. 33, 24 February 2013 (2013-02-24), pages 2584 - 2594, XP028584692
ARAKAWA, CHRISTOPHER KENJI: "A Novel Photopolymerizable Chitosan Collagen Hydrogel for Bone Tissue Engineering", BIOMEDICAL ENGINEERING, 2012, pages i - x and 1-83, XP055462859
HU , JUNLI ET AL.: "Visible Light Crosslinkable Chitosan Hydrogels for Tissue Engineering", ACTA BIOMATERIALIA, vol. 8, 30 January 2012 (2012-01-30), pages 1730 - 1738, XP028476145
Attorney, Agent or Firm:
KIM, Sung Ho et al. (KR)
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