Title:
VITAMIN D3 LACTONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2004/067525
Kind Code:
A1
Abstract:
A compound represented by the following formula (1) or a pharmaceutically acceptable solvate of the compound. They are effective in treatments for Paget's bone diseases or hyperpotassemia. (1) (R1 represents hydrogen, optionally hydroxylated C1-6 alkyl, or optionally hydroxylated C1-6 alkoxy, and R2a and R2b each represents hydrogen, optionally hydroxylated C1-10 alkyl, optionally hydroxylated C6-10 aryl, or optionally hydroxylated C7-12 aralkyl or R2a and R2b in combination represent ethylene, provided that the compounds in which R1 is hydrogen or methyl and R2a and R2b are hydrogen are excluded.)
Inventors:
TAKENOUCHI KAZUYA (JP)
ANZAI MIYUKI (JP)
SAITO HIROSHI (JP)
OKADA KAZUHISA (JP)
ISHIZUKA SEIICHI (JP)
MIURA DAISHIRO (JP)
TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SAITO NOZOMI (JP)
FUJISHIMA TOSHIE (JP)
ANZAI MIYUKI (JP)
SAITO HIROSHI (JP)
OKADA KAZUHISA (JP)
ISHIZUKA SEIICHI (JP)
MIURA DAISHIRO (JP)
TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SAITO NOZOMI (JP)
FUJISHIMA TOSHIE (JP)
Application Number:
PCT/JP2004/000815
Publication Date:
August 12, 2004
Filing Date:
January 29, 2004
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
TAKENOUCHI KAZUYA (JP)
ANZAI MIYUKI (JP)
SAITO HIROSHI (JP)
OKADA KAZUHISA (JP)
ISHIZUKA SEIICHI (JP)
MIURA DAISHIRO (JP)
TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SAITO NOZOMI (JP)
FUJISHIMA TOSHIE (JP)
TAKENOUCHI KAZUYA (JP)
ANZAI MIYUKI (JP)
SAITO HIROSHI (JP)
OKADA KAZUHISA (JP)
ISHIZUKA SEIICHI (JP)
MIURA DAISHIRO (JP)
TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SAITO NOZOMI (JP)
FUJISHIMA TOSHIE (JP)
International Classes:
A61P3/10; A61P3/14; A61P5/18; A61P9/12; A61P11/00; A61P17/00; A61P17/06; A61P17/10; A61P17/14; C07D307/58; (IPC1-7): C07D307/58; A61K31/593; A61P3/10; A61P3/14; A61P5/18; A61P9/12; A61P11/00; A61P17/00; A61P17/06; A61P17/10; A61P17/14
Domestic Patent References:
| WO2003070716A1 | 2003-08-28 | |||
| WO1995033716A1 | 1995-12-14 | |||
| WO2000024712A1 | 2000-05-04 | |||
| WO1998050353A1 | 1998-11-12 | |||
| WO2002015894A2 | 2002-02-28 |
Foreign References:
| JPH11116551A | 1999-04-27 | |||
| EP1123921A1 | 2001-08-16 | |||
| EP0712843A1 | 1996-05-22 | |||
| JPH11116551A | 1999-04-27 |
Other References:
See also references of EP 1589009A4
BLOOD, vol. 73, 1989, pages 235 - 239
BLOOD, vol. 82, 1993, pages 1383 - 1394
N. ENGL. J. MED., vol. 311, 1984, pages 1683 - 1685
J. CLIN. ENDOCRINOL. METAB., vol. 60, 1985, pages 960 - 966
AM. J. MED., vol. 74, 1983, pages 721 - 724
N. ENGL. J. MED., vol. 311, 1984, pages 1103 - 1105
AM. J. NEPHROL., vol. 13, 1993, pages 275 - 277
AM. J. MED. SCI., vol. 301, 1991, pages 178 - 181
ANN. INTERN MED., vol. 105, 1986, pages 890 - 891
FUJISHIMA ET AL., BIOORG. MED. CHEM., vol. 8, 2000, pages 123
FUJISHIMA ET AL., BIOORG. MED. CHEM., vol. 8, no. 123, 2000
BLOOD, vol. 73, 1989, pages 235 - 239
BLOOD, vol. 82, 1993, pages 1383 - 1394
N. ENGL. J. MED., vol. 311, 1984, pages 1683 - 1685
J. CLIN. ENDOCRINOL. METAB., vol. 60, 1985, pages 960 - 966
AM. J. MED., vol. 74, 1983, pages 721 - 724
N. ENGL. J. MED., vol. 311, 1984, pages 1103 - 1105
AM. J. NEPHROL., vol. 13, 1993, pages 275 - 277
AM. J. MED. SCI., vol. 301, 1991, pages 178 - 181
ANN. INTERN MED., vol. 105, 1986, pages 890 - 891
FUJISHIMA ET AL., BIOORG. MED. CHEM., vol. 8, 2000, pages 123
FUJISHIMA ET AL., BIOORG. MED. CHEM., vol. 8, no. 123, 2000
Attorney, Agent or Firm:
Mihara, Hideko c/o Teijin Intellectual Property Center Limited 1-1 (Uchisaiwaicho 2-chome Chiyoda-ku Tokyo, 11, JP)
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